diethyl ether
1,1'-oxybisethane
 
Notes:
a mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. it is mildly irritating to skin and mucous membranes.
  • ECSA Chemicals
    • ECSA Chemicals
      Human Chemistry
      ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide.
      ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators.
      Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials.
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      Product(s):
      RE-340762 DIETHYL ETHER RE-PURE-STABILIZED WITH BHT, K
      RE-447521 DIETHYL ETHER RPE-FOR ANALYSIS-STAB. WITH BH
      RE-447522 DIETHYL ETHER RPE-FOR ANALYSIS-STABILIZED WI
      RE-447534 DIETHYL ETHER RPE-ACS-FOR ANALYSIS-REAG. PH.
      RE-447539 DIETHYL ETHER RPE-ACS PH.EUR.-R - LT 5
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
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      Product(s):
      04-14750 DIETHYL ETHER
       
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CAS Number: 60-29-7Picture of molecule3D/inchi
Other(deleted CASRN): 74446-43-8
ECHA EINECS - REACH Pre-Reg: 200-467-2
FDA UNII: 0F5N573A2Y
Nikkaji Web: J1.925I
Beilstein Number: 1696894
MDL: MFCD00011646
XlogP3: 0.90 (est)
Molecular Weight: 74.12290000
Formula: C4 H10 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: extraction solvents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Additive: Diethyl Ether
GSFA Codex: View
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Physical Properties:
Appearance: colorless clear liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.71500 @  25.00 °C.
Melting Point: -116.00 to -115.00 °C. @ 760.00 mm Hg
Boiling Point: 34.00 to  35.00 °C. @ 760.00 mm Hg
Boiling Point: 10.00 to  11.00 °C. @ 300.00 mm Hg
Vapor Pressure: 538.000000 mmHg @ 25.00 °C.
Flash Point: -40.00 °F. TCC ( -40.00 °C. )
logP (o/w): 0.890
Soluble in:
 alcohol
 water, 2.324e+004 mg/L @ 25 °C (est)
 water, 6.04E+04 mg/L @ 25 °C (exp)
Insoluble in:
 water
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Organoleptic Properties:
Odor Description:
at 1.00 % in dipropylene glycol. 
ethereal
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: solvents
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Suppliers:
ECSA Chemicals
DIETHYL ETHER RE-PURE-STABILIZED WITH BHT, K
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
DIETHYL ETHER RPE-ACS PH.EUR.-R - LT 5
ECSA Chemicals
DIETHYL ETHER RPE-ACS-FOR ANALYSIS-REAG. PH.
ECSA Chemicals
DIETHYL ETHER RPE-FOR ANALYSIS-STAB. WITH BH
ECSA Chemicals
DIETHYL ETHER RPE-FOR ANALYSIS-STABILIZED WI
EMD Millipore
For experimental / research use only.
Diethyl Ether
LyondellBasell Industries
Diethyl Ether
Penta International
DIETHYL ETHER
Sigma-Aldrich
For experimental / research use only.
Diethyl ether, contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7%
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  1215 mg/kg
Toxicology and Applied Pharmacology. Vol. 19, Pg. 699, 1971.

intraperitoneal-guinea pig LDLo  2000 mg/kg
American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.

oral-man LDLo  260 mg/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

intraperitoneal-mouse LD50  2420 mg/kg
Proceedings of the Western Pharmacology Society. Vol. 27, Pg. 511, 1984.

intravenous-mouse LD50  996 mg/kg
Journal of Pharmaceutical Sciences. Vol. 67, Pg. 566, 1978.

Dermal Toxicity:
skin-rabbit LD50 > 20 ml/kg
American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

subcutaneous-frog LDLo 24000 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.

subcutaneous-mouse LDLo 8 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1295, 1935.

Inhalation Toxicity:
inhalation-dog LCLo 76000 ppm
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935.

inhalation-human TCLo 200 ppm
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943.

inhalation-mouse LC50 31000 ppm/30M
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Experimental Animals. Jikken Dobutso Iho. Vol. 34, Pg. 379, 1985.

inhalation-rabbit LCLo 106000 ppm
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1294, 1935.

inhalation-rat LCLo 32000 ppm/4H
American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

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Safety in Use Information:
Category: extraction solvents
Recommendation for diethyl ether usage levels up to:
 not for fragrance use.
 
Recommendation for diethyl ether flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
EPA-Iris: IRIS
ClinicalTrials.gov: search
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 60-29-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3283
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 ethoxyethane
Chemidplus: 0000060297
EPA/NOAA CAMEO: hazardous materials
RTECS: 60-29-7
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References:
 ethoxyethane
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 60-29-7
Pubchem (cid): 3283
Pubchem (sid): 134972928
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C13240
HMDB (The Human Metabolome Database): Search
FooDB: FDB004482
Export Tariff Code: 2909.11.0000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
•grade: usp (for anesthesia); acs reagent; acs absolute; cp; concentrated; usp 1880; washed; motor; electronic. •usi (national distillers) produces four grades: unrefined, usp, acs, and anhydrous. •two grades of diethyl ether are commercially available: technical-grade ether and anesthetic ether. there are no universally accepted specifications for technical-grade ether, but it is conventionally free of peroxides. anhydrous technical-grade ether has a maximum water content of 500 mgkg. anesthetic ether has a neutral reaction, is free from foreign odors, passes the tests for peroxides and aldehydes, and has a maximum water content of 0.2%
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Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 sauromatum guttatum
Search Trop  Picture
 tea leaf
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 diethyl oxide
1,1'-oxybisethane
 ether
 ethoxyethane
 ethyl ether
Synonyms   Articles   Notes   Search   Top
Articles:
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PubMed: Confirmatory analysis of stanozolol metabolites in bovine, pig and sheep urines using an optimized clean-up and liquid chromatography-tandem mass spectrometry.
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PubMed: Bioactive and nutritive compounds in Sorghum bicolor (Guinea corn) red leaves and their health implication.
PubMed: [Isolation and identification of shellfish toxins from contaminated blue mussel (Mytilus edulis) from the East China Sea].
PubMed: Determination of sphingoid bases from hydrolyzed glucosylceramide in rice and wheat by online post-column high-performance liquid chromatography with O-phthalaldehyde derivatization.
PubMed: Optimization of ultrasonic-assisted extraction of pomegranate (Punica granatum L.) seed oil.
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PubMed: Quantitative determination of gymnodimine-A by high performance liquid chromatography in contaminated clams from Tunisia coastline.
PubMed: 2-Propanol in the mobile phase reduces the time of analysis of CLA isomers by silver ion-HPLC.
PubMed: A novel and sensitive method for ethinylestradiol quantification in human plasma by high-performance liquid chromatography coupled to atmospheric pressure photoionization (APPI) tandem mass spectrometry: application to a comparative pharmacokinetics study.
PubMed: Selective extraction of triazine herbicides from food samples based on a combination of a liquid membrane and molecularly imprinted polymers.
PubMed: Determination of dialkyl phosphates as breakdown products of organophosphorus insecticides in fruit juices by HPTLC with fluorescence detection.
PubMed: Analysis of phytosterols in extra-virgin olive oil by nano-liquid chromatography.
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PubMed: Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma.
PubMed: Influence of prefermentative treatments to the major volatile compounds of Assyrtiko wines.
PubMed: LC-DAD-MS (ESI+) analysis and antioxidant capacity of crocus sativus petal extracts.
PubMed: Quantitative determination of some food dyes using digital processing of images obtained by thin-layer chromatography.
PubMed: A comparison of carbon and nitrogen stable isotope ratios of fish tissues following lipid extractions with non-polar and traditional chloroform/methanol solvent systems.
PubMed: Characterization of pyrazines in some Chinese liquors and their approximate concentrations.
PubMed: Antimicrobial activity of extracts of the lichen Parmelia sulcata and its salazinic acid constituent.
PubMed: Aloe ferox leaf gel phytochemical content, antioxidant capacity, and possible health benefits.
PubMed: Facile and efficient syntheses of (3Z,6Z,9Z)-3,6,9-nonadecatriene and homologues: pheromone and attractant components of lepidoptera.
PubMed: Eicosapentaenoic acid enrichment from sardine oil by argentation chromatography.
PubMed: Determination of nifedipine in human plasma and its use in bioequivalence study.
PubMed: Development and validation of a rapid headspace gas chromatography-mass spectrometry method for the determination of diethyl ether and acetone residues in Tween extracts of shellfish intended for mouse bioassay for diarrhoetic toxins.
PubMed: Fast cleanup method for the analysis of Sudan I-IV and para red in various foods and paprika color (oleoresin) by high-performance liquid chromatography/diode array detection: focus on removal of fat and oil as fatty acid methyl esters prepared by transesterification of acylglycerols.
PubMed: Solvent type affects the number, distribution, and relative quantities of volatile compounds found in sweet whey powder.
PubMed: Analysis of extracted and volatile components in blackstrap molasses feed as candidate house fly attractants.
PubMed: Determination of 6-gingerol in ginger (Zingiber officinale) using high-performance thin-layer chromatography.
PubMed: The effects of inulin supplementation of diets with or without hydrolysed protein sources on digestibility, faecal characteristics, haematology and immunoglobulins in dogs.
PubMed: Determination and levels of the biocide ortho-phenylphenol in canned beers from different countries.
PubMed: Use of accelerating solvent extraction for detecting non-steroidal anti-inflammatory drugs in horse feces.
PubMed: Antioxidant properties of methanolic extracts from leaves of Rhazya stricta.
PubMed: Comparison of odor-active volatile compounds of fresh and smoked salmon.
PubMed: Isolation of 6-methoxy gossypol and 6,6'-dimethoxy gossypol from Gossypium barbadense Sea Island cotton.
PubMed: Comparison of different fluorimetric signals for the simultaneous multivariate determination of tocopherols in vegetable oils.
PubMed: Importance of insoluble-bound phenolics to antioxidant properties of wheat.
PubMed: Novel solid-phase extraction method to separate 4-desmethyl-, 4-monomethyl-, and 4,4'-dimethylsterols in vegetable oils.
PubMed: [Analysis of phenmedipham in agricultural products by HPLC].
PubMed: Flavor profiles of full-fat and reduced-fat cheese and cheese fat made from aged Cheddar with the fat removed using a novel process.
PubMed: Determination of low molecular weight alcohols including fusel oil in various samples by diethyl ether extraction and capillary gas chromatography.
PubMed: Determination of 3-chloropropane-1,2-diol as its 1,3-dioxolane derivative at the microg kg-1 level: application to a wide range of foods.
PubMed: Simultaneous determination of multiple phytohormones in plant extracts by liquid chromatography-electrospray tandem mass spectrometry.
PubMed: Characterization of dried whey protein concentrate and isolate flavor.
PubMed: The effect of anesthesia by diethyl ether or isoflurane on activity of cytochrome P450 2E1 and P450 reductases in rat liver.
PubMed: Relative retention order of all isomers of cis/trans conjugated linoleic acid FAME from the 6,8- to 13,15-positions using silver ion HPLC with two elution systems.
PubMed: Extraction and identification of natural antioxidant from Sideritis euboea (mountain tea).
PubMed: Quantification of carvedilol in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry: application to bioequivalence study.
PubMed: Total lipid extraction of homogenized and intact lean fish muscles using pressurized fluid extraction and batch extraction techniques.
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PubMed: Ticlopidine quantification in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry. Application to bioequivalence study.
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PubMed: Improved identification of conjugated linoleic acid isomers using silver-ion HPLC separations.
PubMed: The effects of sample preparation and gas chromatograph injection techniques on the accuracy of measuring guaiacol, 4-methylguaiacol and other volatile oak compounds in oak extracts by stable isotope dilution analyses.
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PubMed: Identification and quantification of carotenoids including geometrical isomers in fruit and vegetable juices by liquid chromatography with ultraviolet-diode array detection.
PubMed: Bromazepam determination in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry: a highly sensitive and specific tool for bioequivalence studies.
PubMed: Compound-specific carbon isotope analysis of volatile organic compounds in the low-microgram per liter range.
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PubMed: Crude fat, diethyl ether extraction, in feed, cereal grain, and forage (Randall/Soxtec/submersion method): collaborative study.
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PubMed: Determination of free and total phenolic acids in plant-derived foods by HPLC with diode-array detection.
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PubMed: Purification of saponin compounds in Bupleurum falcatum by solvent partitioning and preparative LC.
PubMed: [Determination of bisphenol A in foods using GC/MS].
PubMed: [Drying ability of anhydrous sodium sulfate on wet organic solvents after liquid-liquid partition].
PubMed: Isolation of lipid and 2-alkylcyclobutanones from irradiated foods by supercritical fluid extraction.
PubMed: The validity of two HPLC methods and a colorimetric PP2A assay related to the mouse bioassay in quantification of diarrhetic toxins in blue mussels (Mytilus edulis).
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PubMed: Separation of phenolic compounds by high-performance liquid chromatography with absorbance and fluorimetric detection.
PubMed: A novel method to analyze betaine in chicken liver: effect of dietary betaine and choline supplementation on the hepatic betaine concentration in broiler chicks.
PubMed: Fourier transform infrared determination of caffeine in roasted coffee samples.
PubMed: Monthly variations in diarrhetic toxins and yessotoxin in shellfish from coast to the inner part of the Sognefjord, Norway.
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PubMed: Determination of biogenic amines in cheese.
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PubMed: Determination of phenylbutazone residues in bovine milk by liquid chromatography with UV detection.
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PubMed: Characterization of a cytosolic protein in rat liver inhibiting neutral cholesteryl ester hydrolase.
PubMed: Stereoselectivity of lipases: esterification reactions of octadecylglycerol.
PubMed: N,N'-diethyl-m-toluamide (m-DET): analysis of an insect repellent in human urine and serum by high-performance liquid chromatography.
PubMed: Reversed-phase high-performance liquid chromatographic determination of dexamethasone in bovine tissues.
PubMed: A qualitative colorimetric test for brominated vegetable oil in soft drinks.
PubMed: Rapid chromatographic analysis of fatty acid anilides suspected of causing toxic oil syndrome.
PubMed: Gas chromatographic-mass spectrometric determination of oxolinic acid in fish using selected ion monitoring.
PubMed: Determination of N-nitrosodimethylamine in fish products using gas chromatography with nitrogen-phosphorus detection.
PubMed: The effect of extrathyroidal conversion inhibitor from food-deprived animals on iodothyronines deiodination by pituitary and cerebral cortical homogenates in vitro.
PubMed: [Use of gas chromatography for determining benzoic and sorbic acid levels in orange beverage and tomato concentrate].
PubMed: Chemiluminescence immunoassay for the detection and quantification of methyltestosterone residues in muscle tissue.
PubMed: Spectrophotometric method for the determination of sorbic acid in various food samples with iron(III) and 2-thiobarbituric acid as reagents.
PubMed: Liquid chromatographic separation and fluorometric determination of cis- and trans-isoeugenol in perfumes, colognes, and toilet waters.
PubMed: Thin-layer chromatographic screening method for the tranquillizers azaperone, propiopromazine and carazolol in pig tissues.
PubMed: High-performance liquid chromatographic determination of nicotinamide in rat tissue samples and blood after extraction with diethyl ether.
PubMed: Comparison of diethyl ether and ethyl acetate as extracting agents for recovery of Ascaris spp. and Trichuris spp. eggs.
PubMed: Identification of mammalian feces by coprostanol thin layer chromatography: method development.
PubMed: Arteriovenous glucose differences across the mammary gland of the fed, starved, and re-fed lactating rat.
PubMed: Occurrence of pancreatic ductal cell dysplasia in rats fed with a high fat diet and ethanol.
PubMed: HPLC determination of N-nitrosomethylurea in biological fluids by reaction with 4-nitrothiophenol.
PubMed: High-performance liquid chromatographic screening and confirmation methods for chloramphenicol residues in meat with off-line cartridge sample clean-up and on-line diode array UV-VIS detection.
PubMed: Determination of total iron in foods by isotope dilution fast atom bombardment mass spectrometry.
PubMed: Attractancy toOryzaephilus surinamensis (L.) of volatile materials isolated from vacuum distillate of heat-treated carobs.
PubMed: [High resolution liquid chromatography (HPLC) analysis of the vitamin A and beta-carotene content of heat-treated precooked food].
PubMed: Mutagenic nitropyrenes in foods.
PubMed: Gravimetric method for the determination of insoluble and soluble dietary fibres.
PubMed: The mutagenicity of some edible mushrooms in the Ames test.
PubMed: Mutagenicity of hydrolysates of citrus fruit juices.
PubMed: Substrate concentration changes during pregnancy in the conscious rat.
PubMed: Neonatal diarrhoea in calves given milk-substitutes differing in fat source and fed by different procedures.
PubMed: Rapid determination of the 3-methylhistidine content of meat using 1-fluoro-2,4-dinitrobenzene.
PubMed: A field outbreak of suspected stachybotryotoxicosis in sheep.
PubMed: Gluconeogenesis from storage wax in the cotyledons of jojoba seedlings.
PubMed: Nitrogen retention in rats fed on diets enriched with arginine and glycine. 2. Effect of diethyl ether anaesthesia on N retention.
PubMed: Estimation of zinc pheophytins, chlorophylls, and pheophytins in mixtures in diethyl ether or 80% acetone by spectrophotometry and fluorometry.
PubMed: Estimation of copper pheophytins, chlorophylls, and pheophytins in mixtures in diethyl ether.
PubMed: [On the contamination of milk and milk products with chlorinated hydrocarbons. I. Methods].
PubMed: Detection of antithyroid residues in meat and some organs of slaughtered animals.
PubMed: The photochemistry of imidan in diethyl ether.
PubMed: [A hygienic study of "PIREF" (diethyl ether of pyrocarbonic acid) and the possibility of its use in the food industry].
PubMed: 3,5-di-Tert-butyl-4-hydroxytoluene (BHT) as an artifact from diethyl ether.
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