Articles:
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1-chloro-2,3-epoxypropane
Notes:
Used for cross-linking dextrose units in food starch
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| CAS Number: | 106-89-8 |  3D/inchi
|
| Other(deleted CASRN): | 109351-74-8 | |
| ECHA EINECS - REACH Pre-Reg: | 203-439-8 | |
| FDA UNII: | 08OOR508C0 | |
| Nikkaji Web: | J4.037A | |
| Beilstein Number: | 0079785 | |
| MDL: | MFCD00005132 | |
| XlogP3-AA: | 0.50 (est) | |
| Molecular Weight: | 92.52405000 | |
| Formula: | C3 H5 Cl O | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| DG SANTE Food Contact Materials: | epichlorohydrin |
| FDA Mainterm (IAUFC): | 106-89-8 ; EPICHLOROHYDRIN |
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.18100 to 1.18400 @ 20.00 °C. |
| Pounds per Gallon - (est).: | 9.839 to 9.864 |
| Refractive Index: | 1.43600 to 1.44000 @ 20.00 °C. |
| Flash Point: | 93.00 °F. TCC ( 33.89 °C. ) |
| Soluble in: | |
| water, 6.59E+04 mg/L @ 25 °C (exp) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Covalent Chemical |
| Epichlorohydrin |
| Shiva Chemicals and Pharmaceuticals |
| Epichlorohydrin |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| epiChlorohydrin ≥99% |
| TCI AMERICA |
| For experimental / research use only. |
| epiChlorohydrin >99.0%(GC) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-guinea pig LD50 118 mg/kg Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972. oral-guinea pig LD50 280 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 46, 1968. intraperitoneal-mouse LD50 170 mg/kg Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972. oral-mouse LD50 195 mg/kg BEHAVIORAL: ATAXIA BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 46, 1968. intraperitoneal-rabbit LD50 160 mg/kg Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972. oral-rabbit LD50 345 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(1), Pg. 46, 1968. intraperitoneal-rat LD50 113 mg/kg Journal of Pharmaceutical Sciences. Vol. 61, Pg. 1712, 1972. intravenous-rat LD50 154 mg/kg Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 41, 1974. oral-rat LD50 90 mg/kg Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 63, 1948. | |
| Dermal Toxicity: | |
|
skin-mouse LD50 250 mg/kg "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 64, 1982. subcutaneous-mouse LDLo 250 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BEHAVIORAL: MUSCLE WEAKNESS Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 2, Pg. 28, 1961. skin-rabbit LD50 515 mg/kg Personal Communication from M.A. Wolf, Dow Chemical Co., Midland, MI 48640, Jan. 18, 1977Vol. 18JAN1977 subcutaneous-rat LD50 150 mg/kg KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 28, Pg. 505, 1967. skin-rat LDLo 1000 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER University of California, Berkeley, Publications in Pharmacology. Vol. 2, Pg. 69, 1941. | |
| Inhalation Toxicity: | |
|
inhalation-human TCLo 20 ppm SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968Vol. -, Pg. 108, 1968. inhalation-human TCLo 40 ppm/2H LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 240, 1969. inhalation-mouse LCLo 72000 mg/m3/9M Journal of Biomedical Materials Research. Vol. 8, Pg. 11, 1974. inhalation-rat LC50 250 ppm/8H Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 41, 1974. | |
Safety in Use Information:
| Category: | indirect food additives: adhesives and components of coatings | ||
| Recommendation for epichlorohydrin usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for epichlorohydrin flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| EPA-Iris: | IRIS |
| NIOSH International Chemical Safety Cards: | search |
| NIOSH Pocket Guide: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 106-89-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 7835 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 2-(chloromethyl)oxirane | |
| Chemidplus: | 0000106898 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 106-89-8 |
References:
| 2-(chloromethyl)oxirane | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 106-89-8 |
| Pubchem (cid): | 7835 |
| Pubchem (sid): | 134972083 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C14449 |
| HMDB (The Human Metabolome Database): | HMDB34232 |
| FooDB: | FDB012543 |
| Export Tariff Code: | 2910.30.0000 |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| 1- | chloro-2,3-epoxypropane |
| 2-( | chloromethyl)oxirane |
| 1,2- | epoxy-3-chloropropane |
| glycidyl chloride | |
| propane, 1-chloro-2,3-epoxy- |