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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless crystals (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 205.00 °C. @ 760.00 mm Hg
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| Soluble in: |
| | water, 1.313e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for dextro,laevo-proline usage levels up to: | | | not for fragrance use.
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| Recommendation for dextro,laevo-proline flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Safety of proline-specific oligopeptidase as a novel food pursuant to Regulation (EC) No 258/97 View page or View pdf |
| EPI System: | View |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 609-36-9 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 614 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | pyrrolidine-2-carboxylic acid |
| Chemidplus: | 0000609369 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| DL- | proline | | | proline DL-form | | | proline, DL- | | 2- | pyrrolidine carboxylic acid | | | pyrrolidine-2-carboxylic acid | | (+/-)- | pyrrolidine-2-carboxylic acid | | (R,S)- | pyrrolidine-2-carboxylic acid | | DL- | pyrrolidine-2-carboxylic acid | | DL-2- | pyrrolidinecarboxylic acid |
Articles:
| PubMed: | Thermodynamic and conformational study of proline stereoisomers. |
| PubMed: | The γ-aminobutyrate permease GabP serves as the third proline transporter of Bacillus subtilis. |
| PubMed: | Concise NMR approach for molecular dynamics characterizations in organic solids. |
| PubMed: | A domino Knoevenagel hetero-Diels-Alder reaction for the synthesis of polycyclic chromene derivatives and evaluation of their cytotoxicity. |
| PubMed: | L-Proline nutrition and catabolism in Staphylococcus saprophyticus. |
| PubMed: | Structural characterization and reactivity of gamma-octamolybdate functionalized by proline. |
| PubMed: | [Ligand exchange chromatographic separation of DL-amino acids based on monodisperse resin-bonded chiral stationary phase]. |
| PubMed: | DL-Proline. |
| PubMed: | Oxidation of 3,4-dehydro-D-proline and other D-amino acid analogues by D-alanine dehydrogenase from Escherichia coli. |
| PubMed: | Probing the reaction pathways of DL-proline on TiO2 (001) single crystal surfaces. |
| PubMed: | Transport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1. |
| PubMed: | Identification of regions of the tomato gamma-glutamyl kinase that are involved in allosteric regulation by proline. |
| PubMed: | Dichlorobis(DL-proline-kappaO)zinc(II). |
| PubMed: | Three modifications in the D and T arms of tRNA influence translation in Escherichia coli and expression of virulence genes in Shigella flexneri. |
| PubMed: | Chiral polyoxotungstates. 1. Stereoselective interaction of amino acids with enantiomers of [Ce(III)(alpha1-P2W17O61)(H2O)x]7-. The structure of DL-[Ce2(H2O)8(P2W17O61)2]14-. |
| PubMed: | Accurate experimental electronic properties of dl-proline monohydrate obtained within 1 Day |
| PubMed: | The influence of proline analogs on bleomycin-induced lung injury in rats. |
| PubMed: | Purification and Characterization of an l-Amino Amidase from Mycobacterium neoaurum ATCC 25795. |
| PubMed: | Effect of novel compound, 1-methyl-1-piperidino methane sulfonate (MPMS), on the osmoprotectant activity of glycine betaine, choline and L-proline in Escherichia coli. |
| PubMed: | Inhibitors of C1q biosynthesis suppress activation of murine macrophages for both antibody-independent and antibody-dependent tumor cytotoxicity. |
| PubMed: | Effects of inhibitors of C1q biosynthesis on macrophage Fc receptor subclass-mediated antibody-dependent cellular cytotoxicity and phagocytosis. |
| PubMed: | Energetics of proline racemase: transition-state fractionation factors for the two protons involved in the catalytic steps. |
| PubMed: | Channel structures in synthetic polypeptides with alternating configurations. Conformational analysis of poly(DL-proline). |
| PubMed: | Poly(DL-proline), a synthetic polypeptide behaving as an ion channel across bilayer membranes. |
| PubMed: | Identification of a mutation that relieves gamma-glutamyl kinase from allosteric feedback inhibition by proline. |
| PubMed: | L-Proline transport in Saccharomyces cerevisiae. |
| PubMed: | Proline transport in Saccharomyces cerevisiae. |
| PubMed: | Retrograde amnesia in chicks and mice induced by 3,4-dehydro-DL-proline, a proline analog. |
| PubMed: | Construction of an L-arginine-producing mutant in Serratia marcescens. Use of the wide substrate specificity of acetylornithinase. |
| PubMed: | Potential inhibitors of collagen biosynthesis, 4,4-Difluoro-L-proline and 4,4-dimethyl-DL-proline and their activation by prolyl-tRNA ligase. |
| PubMed: | The use of hydroxy-DL-proline-2-(14)C in the investigation of hydroxyproline metabolism in normal subjects and in patients with renal insufficiency. |
| PubMed: | Preparation of optically active proline. Optical resolution of N-acyl-DL-proline by preferential crystallization procedure. |
| PubMed: | Differences in the incorporation of L- and DL-Amino acids into renal tubular cells. An autoradiographic study. |
| PubMed: | 13C magnetic resonance study of the ionization of N-acetyl-DL-proline in aqueous solution. |
| PubMed: | Induction of prodigiosin biosynthesis after shift-down in temperature of nonproliferating cells of Serratia marcescens. |
| PubMed: | Proline as an intermediate in the reductive deamination of ornithine to delta-aminovaleric acid. |
| PubMed: | Effect of structural and stereochemical methylproline isomers on actinomycin biosynthesis. |
| PubMed: | Purification, properties and comparative specificities of the enzyme prolyl-transfer ribonucleic acid synthetase from Phaseolus aureus and Polygonatum multiflorum. |
| PubMed: | PROLINE OXIDASES IN HANSENULA SUBPELLICULOSA. |
| PubMed: | SYNTHESIS OF 4-METHYLENE-DL-PROLINE: A NATURALLY OCCURRING RACEMIC AMINO-ACID. |
| PubMed: | EFFECT OF 3,4-DEHYDRO-DL-PROLINE ON GROWTH AND PROTEIN SYNTHESIS. |
| PubMed: | The synthesis of amino acids from 2,3-dihydrofuran DL-ornithine, DL-proline, and DL-alpha-amino-delta-hydroxyvaleric acid. |
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