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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 234.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 204.00 °F. TCC ( 95.30 °C. ) (est)
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| logP (o/w): | 0.920 (est) |
| Soluble in: |
| | water, 1.18E+04 mg/L @ 25 °C (exp) | | | water, 1.569e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for dextro,laevo-norleucine usage levels up to: | | | not for fragrance use.
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| Recommendation for dextro,laevo-norleucine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | aminocaproic acid | | DL-a- | aminocaproic acid | | (±)-2- | aminohexanoic acid | | 2- | aminohexanoic acid | | (+-)-nor | leucine | | D-(-)-nor | leucine | | DL-nor | leucine | | nor | leucine, D-(-)- |
Articles:
| PubMed: | Non-physiological amino acid (NPAA) therapy targeting brain phenylalanine reduction: pilot studies in PAHENU2 mice. |
| PubMed: | Solid-state phase transitions of DL-aminobutyric acid. |
| PubMed: | Size-dependent phase stability of a molecular nanocrystal: a proxy for investigating the early stages of crystallization. |
| PubMed: | Solid-state phase transitions in DL-norvaline studied by single-crystal X-ray diffraction. |
| PubMed: | Solid-solid phase transitions in DL-norvaline studied by differential scanning calorimetry and Raman spectroscopy. |
| PubMed: | Concerted molecular displacements in a thermally-induced solid-state transformation in crystals of DL-norleucine. |
| PubMed: | Spontaneous resolution of binary copper(II) complexes with racemic dipeptides: crystal structures of glycyl-L-alpha-amino-n-butyrato copper(II) monohydrate, glycyl-D-valinato copper(II) hemihydrate, and glycyl-L-valinato copper(II) hemihydrate. |
| PubMed: | Burkholderia fungorum sp. nov. and Burkholderia caledonica sp. nov., two new species isolated from the environment, animals and human clinical samples. |
| PubMed: | Subsite preferences of pepstatin-insensitive carboxyl proteinases from prokaryotes: kumamolysin, a thermostable pepstatin-insensitive carboxyl proteinase. |
| PubMed: | Separations of enantiomers by preparative capillary isotachophoresis. |
| PubMed: | The effect of chlorambucil upon lysozyme activity. |
| PubMed: | Identification of carboxyl residues in pepstatin-insensitive carboxyl proteinase from Pseudomonas sp. 101 that participate in catalysis and substrate binding. |
| PubMed: | Substrate specificities of pepstatin-insensitive carboxyl proteinases from gram-negative bacteria. |
| PubMed: | Characterisation of a thermostable pepstatin-insensitive acid proteinase from a Bacillus sp. |
| PubMed: | A pepstatin-insensitive aspartic proteinase from a thermophilic Bacillus sp. |
| PubMed: | Purification and some properties of a protease from Streptomyces limosus. |
| PubMed: | Purification and characterization of an acid proteinase from Dirofilaria immitis worms. |
| PubMed: | Effect of inhibitors of cell envelope synthesis on beta-sitosterol side chain degradation by Mycobacterium sp. NRRL MB 3683. |
| PubMed: | Purification and characterization of kumamolysin, a novel thermostable pepstatin-insensitive carboxyl proteinase from Bacillus novosp. MN-32. |
| PubMed: | Amino acid imbalance and intracellular protein synthesis. |
| PubMed: | The gene and deduced protein sequences of the zymogen of Aspergillus niger acid proteinase A. |
| PubMed: | Enhancement of drug susceptibility of Mycobacterium avium by inhibitors of cell envelope synthesis. |
| PubMed: | Purification and Characterization of an Extracellular Acid Proteinase from the Ectomycorrhizal Fungus Hebeloma crustuliniforme. |
| PubMed: | Methionine as methyl-group donor in the synthesis of Mycobacterium avium envelope lipids, and its inhibition by DL-ethionine, D-norleucine and DL-norleucine. |
| PubMed: | Tuna pepsinogens and pepsins. Purification, characterization and amino-terminal sequences. |
| PubMed: | Cathepsin D from human leukocytes. Purification by affinity chromatography and properties of the enzyme. |
| PubMed: | Purification and properties of a pepstatin-insensitive carboxyl proteinase from a gram-negative bacterium. |
| PubMed: | Interference by methionine on valine uptake in Acremonium chrysogenum. |
| PubMed: | Purification of an acid protease from Mucor rouxii that inactivates chitin synthetase. |
| PubMed: | Amino acid derived latent isocyanates: irreversible inactivation of porcine pancreatic elastase and human leukocyte elastase. |
| PubMed: | Extracellular proteinases of the isolate of Botrytis cinerea virulent to apple tissues. |
| PubMed: | Acid proteinase activity in fish--I. Comparative study of extraction of cathepsins B and D from Mujil auratus. |
| PubMed: | Purification and characterization of pepsinogens and pepsins from Asiatic black bear, and amino acid sequence determination of the NH2-terminal 60 residues of the major pepsinogen. |
| PubMed: | Identification of monkey lung procathepsin D-II as a pepsinogen-C-like acid protease zymogen. |
| PubMed: | An aspartic proteinase from Fusarium moniliforme. Purification and general properties. |
| PubMed: | Extracellular acid proteases produced by Saccharomycopsis lipolytica. |
| PubMed: | Aspartyl proteinase from cucumber (Cucumis sativus) seeds. Preparation and characteristics. |
| PubMed: | Protease activity associated with loss of adhesiveness in mouse teratocarcinoma. |
| PubMed: | Proton magnetic resonance spectroscopy of an essential histidyl residue in a milk-clotting acid protease, Mucor rennin. |
| PubMed: | Aryl-L-aminoacylamidase activities in extracts of Streptococcus durans. |
| PubMed: | Photo-oxidation of a histidyl residue of milk-clotting acid protease, Mucor rennin. |
| PubMed: | Studies on proteinases from the digestive organs of sardine. II. Purification and characterization of two acid proteinases from the stomach. |
| PubMed: | Purification and properties of proteinase A from yeast. |
| PubMed: | Cathepsins D from rhesus monkey lung. Purification and characterization. |
| PubMed: | Monkey pepsinogens and pepsins. Monkey pepsinogens and pepsins. V. Purification, Characterization, and amino-terminal sequence determination of crab-eating monkey pepsinogens and pepsins. |
| PubMed: | [Acid proteinase of chicken liver. Purification and properties (author's transl)]. |
| PubMed: | A cathepsin D-like acid proteinase from human gastric mucosa. Purification and characterization. |
| PubMed: | Inhibition of the acid proteinase from Neurospora crassa by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(4-nitrophenoxy)propane and pepstatin. |
| PubMed: | Purification and characterization of rat pepsinogens whose contents increase with developmental progress. |
| PubMed: | The structure and function of acid proteases. IX. Isolation and amino acid sequences of the peptides containing the active site aspartyl residues reactive with diazoacetyl-DL-norleucine methyl ester and 1,2-epoxy-3-(p-nitrophenoxy)propane in Rhizopus chinensis acid protease. |
| PubMed: | Nonsteroid anti-inflammatory agents: regulators of the phagocytic secretion of lysosomal enzymes from guinea-pig neutrophils. |
| PubMed: | Inactivation of cathepsin D from human gastric mucosa and from stomach carcinoma by diazoacetyl-DL-norleucine methyl ester. |
| PubMed: | Acid proteases. II. Fluorescence study of the interaction of Cladosporium acid protease with glycyl-DL-norleucine methyl ester in the presence of cupric ions. |
| PubMed: | The structure and function of acid proteases. VIII. Purification and characterization of cathepsins D from Japanese monkey lung. |
| PubMed: | Acid proteases. I. Inactivation of Cladosporium acid protease by diazoacetyl-DL-norleucine methyl ester as an active-site-directed irreversible inhibitor. |
| PubMed: | Sulfur metabolism of a mutant of Cephalosporium acremonium with enhanced potential to utilize sulfate for cephalosporin C production. |
| PubMed: | Pepsinogen C and pepsin C from gastric mucosa of Japanese monkey. Purification and characterization. |
| PubMed: | The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus. |
| PubMed: | The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy) propane and pepstatin. |
| PubMed: | The structure and function of acid proteases. IV. Inactivation of the acid protease from Mucor pusillus by acid protease-specific inhibitors. |
| PubMed: | Pepsinogens and pepsins from gastric mucosa of Japanese Monkey. Purification and characterization. |
| PubMed: | Purification and properties of the thermostable acid protease of Penicillium duponti. |
| PubMed: | Effect of norleucine on mycelial fragmentation in Cephalosporium acremonium. |
| PubMed: | The relevance of the structure of lysine bound to Sepharose for the affinity of rabbit plasminogen;. |
| PubMed: | Specific inhibition of acid proteases from brain, kidney, skeletal muscle, and insectivorous plants by diazoacetyl-DL-norleucine methyl ester and by pepstatin. |
| PubMed: | Kinetics of irreversible enzyme inhibition by an unstable inhibitor. |
| PubMed: | The structure and function of acid proteases. Specific inactivation of an acid protease from Rhizopus chinensis by diazoacetyl-DL-norleucine methyl ester. |
| PubMed: | An active site peptide from pepsin C. |
| PubMed: | Amino acid cross resistance in Agrobacterium tumefaciens. |
| PubMed: | Biosynthesis of chloramphenicol. IV. Incorporation of carbon 14-labled precursors. |
| PubMed: | Nitrogenous compounds in germination and postgerminative development of Bacillus megaterium spores. |
| PubMed: | Induced alterations in metabolism of DL-norleucine-2-C14 in the intact cow. |
| PubMed: | Metabolism of DL-alpha-aminobutyrate-3-14C and DL-norleucine-3-14C. |
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