dextro,laevo-homatropine hydrobromide
homatropine DL- hydrobromide
 
Notes:
None found
  • BOC Sciences
    • BOC Sciences
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      Product(s):
      51-56-9 Homatropine HBr >98%
      Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
       
       
  • Glentham Life Sciences
  • TCI AMERICA
    • TCI AMERICA
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      Product(s):
      H0155 Homatropine Hydrobromide >99.0%(T)
       
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CAS Number: 51-56-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 200-105-3
FDA UNII: BEW7469QZ0
MDL: MFCD00012676
Molecular Weight: 356.25994000
Formula: C16 H22 Br N O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 250.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 1.49E+05 mg/L @ 25 °C (exp)
 water, 2.042e+004 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
Homatropine HBr >98%
Odor: characteristic
Use: Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
ExtraSynthese
For experimental / research use only.
Homatropine Hydrobromide
Glentham Life Sciences
Homatropine hydrobromide
Santa Cruz Biotechnology
For experimental / research use only.
Homatropine Hydrobromide
Sigma-Aldrich
For experimental / research use only.
Homatropine hydrobromide European Pharmacopoeia (EP) Reference Standard
TCI AMERICA
For experimental / research use only.
Homatropine Hydrobromide >99.0%(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50  107 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 96, Pg. 1, 1949.

intraperitoneal-rat LD50  154 mg/kg
Drugs in Japan Vol. 6, Pg. 789, 1982.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: pharmaceuticals / chemical synthisis
Recommendation for dextro,laevo-homatropine hydrobromide usage levels up to:
 not for fragrance use.
 
Recommendation for dextro,laevo-homatropine hydrobromide flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 51-56-9
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5821
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide
Chemidplus: 0000051569
RTECS: YM5602000 for cas# 51-56-9
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References:
 (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5821
Pubchem (sid): 134972439
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2933.99.9700
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 benzeneacetic acid, alpha-hydroxy-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide
 benzeneacetic acid, alpha-hydroxy-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide (1:1)
 benzeneacetic acid, alpha-hydroxy-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, HBr, endo-(+-)
 benzeneacetic acid, alpha-hydroxy-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, hydrobromide, endo-(+-)-
 homatropine (bromhydrate d')
(+-)-homatropine bromide
 homatropine DL- hydrobromide
(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate;hydrobromide
1alphaH,5alphaH-tropan-3alpha-ol mandelate (ester) hydrobromide
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Articles:
PubMed: The effect of topical adrenergic and anticholinergic agents on the choroidal thickness of young healthy adults.
PubMed: Combined use of ionic liquid and β-CD for enantioseparation of 12 pharmaceuticals using CE.
PubMed: Interference of mandelic acid with the determination of homatropine hydrobromide by second-order derivative spectroscopy.
PubMed: Use of topical nonsteroidal anti-inflammatory drugs in excimer laser photorefractive keratectomy.
PubMed: Determination of homatropine hydrobromide in eye drops by second-order derivative spectroscopy.
PubMed: [Correction of the symptoms of late substance withdrawal syndrome by intra-conjunctival administration of 5% homatropine solution (preliminary report)].
PubMed: An evaluation of the effectiveness of intramuscular atropine or homatropine eyedrops in preventing the effects of physostigmine eyedrops on human vision.
PubMed: Effect of urea on the activity of certain ophthalmic drugs in man.
PubMed: Memo on medications: atropine sulfate and homatropine hydrobromide: common mydriatic/cycloplegic agents.
PubMed: Relapsing polychondritis in a Latin American man.
PubMed: [Photometric determination of homatropine hydrobromide in eyedrops].
PubMed: [Cycloplegia and residual accommodation (author's transl)].
PubMed: [Homatropine hydrobromide].
PubMed: Stability determination of homatropine hydrobromide by direct cerimetric titration.
PubMed: HOMATROPINE HYDROBROMIDE. EFFECT OF TOPICAL ADMINISTRATION UPON THE INTRAOCULAR PRESSURE AND AQUEOUS FACILITY VALUES OF NORMAL AND CHRONIC SIMPLE GLAUCOMATOUS EYES.
PubMed: [Use of a 4 per cent solution of homatropine hydrobromide for the determination of refraction in young patients].
PubMed: Ophthalmic vehicles: the effect of methylcellulose on the penetration of homatropine hydrobromide through the cornea.
PubMed: Effects of atropine sulfate, methylatropine nitrate (metropine) and homatropine hydrobromide on adult human eyes.
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