|
Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.23200 to 1.23600 @ 20.00 °C.
|
| Pounds per Gallon - (est).: | 10.263 to 10.297
|
| Refractive Index: | 1.43800 to 1.44200 @ 20.00 °C.
|
| Boiling Point: | 249.60 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
|
| logP (o/w): | -0.830 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for dimethyl (S)-(-)-malate usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for dimethyl (S)-(-)-malate flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | dimethyl (2S)-2-hydroxybutanedioate | | | dimethyl (S)-2-hydroxysuccinate | | | dimethyl (S)-malate | | | dimethyl L-(-)-malate | | L- | malic acid dimethyl ester |
Articles:
| PubMed: | [Chemical constituents from Ganoderma philippii]. |
| PubMed: | Mitochondrial biogenesis and energy production in differentiating murine stem cells: a functional metabolic study. |
| PubMed: | Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening. |
| PubMed: | Tumor cell death induced by the inhibition of mitochondrial electron transport: the effect of 3-hydroxybakuchiol. |
| PubMed: | Advances in mycobacterial isocitrate lyase targeting and inhibitors. |
| PubMed: | Tyrosine kinase receptor inhibitor-targeted combined chemotherapy for metastatic bladder cancer. |
| PubMed: | Supplement of TCA cycle intermediates protects against high glucose/palmitate-induced INS-1 beta cell death. |
| PubMed: | Structure of oxalacetate acetylhydrolase, a virulence factor of the chestnut blight fungus. |
| PubMed: | 6,8-Di-C-glycosyl flavonoids from Dendrobium huoshanense. |
| PubMed: | Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion. |
| PubMed: | Characterization of Desulfomicrobium salsuginis sp. nov. and Desulfomicrobium aestuarii sp. nov., two new sulfate-reducing bacteria isolated from the Adour estuary (French Atlantic coast) with specific mercury methylation potentials. |
| PubMed: | Alteration of DMBA-induced oxidative stress by additive action of a modified indigenous preparation--Kalpaamruthaa. |
| PubMed: | Restorative effect of Kalpaamruthaa, an indigenous preparation, on oxidative damage in mammary gland mitochondrial fraction in experimental mammary carcinoma. |
| PubMed: | Enthalpy change on mixing a couple of S- and R-enantiomers of some chiral compounds at 298.15 K. |
| PubMed: | Gateways to clinical trials. |
| PubMed: | Therapeutic effect of tamoxifen and energy-modulating vitamins on carbohydrate-metabolizing enzymes in breast cancer. |
| PubMed: | A rapid screening method to detect specific inhibitors of pyruvate orthophosphate dikinase as leads for C4 plant-selective herbicides. |
| PubMed: | Anthelmintic efficacy of Flemingia vestita (Fabaceae): alterations in glucose metabolism of the cestode, Raillietina echinobothrida. |
| PubMed: | Characterization of photosynthetic electron transport in bundle sheath cells of maize. I. Ascorbate effectively stimulates cyclic electron flow around PSI. |
| PubMed: | Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue. |
| PubMed: | Mechanism of superoxide anion generation in intact mitochondria in the presence of lucigenin and cyanide. |
| PubMed: | Therapeutic effect of Semecarpus anacardium Linn. nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats. |
| PubMed: | Alpha-cycloPNA: 1-aminocylopentane-1-carboxylic acid-derived peptide nucleic acid. |
| PubMed: | Redox changes in the chloroplast and hydrogen peroxide are essential for regulation of C(3)-CAM transition and photooxidative stress responses in the facultative CAM plant Mesembryanthemum crystallinum L. |
| PubMed: | Synthesis and characterization of poly(butylene succinate-co-butylene malate): a new biodegradable copolyester bearing hydroxyl pendant groups. |
| PubMed: | Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis. |
| PubMed: | A new approach for asymmetric synthesis of (R)-3-methylpyrrolidine alkaloids from (S)-malic acid. |
| PubMed: | Control of dimethylsulfoxide reductase expression in Rhodobacter capsulatus: the role of carbon metabolites and the response regulators DorR and RegA. |
| PubMed: | FlhD/FlhC-regulated promoters analyzed by gene array and lacZ gene fusions. |
| PubMed: | Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten. |
| PubMed: | Vacuolar chloride transport in Mesembryanthemum crystallinum L. measured using the fluorescent dye lucigenin. |
| PubMed: | Biochemical characterization of lucigenin (Bis-N-methylacridinium) as a chemiluminescent probe for detecting intramitochondrial superoxide anion radical production. |
| PubMed: | Sulfidogenesis from 2-aminoethanesulfonate (taurine) fermentation by a morphologically unusual sulfate-reducing bacterium, Desulforhopalus singaporensis sp. nov. |
| PubMed: | Effects of starvation and diabetes on the metabolism of [2,3-13C]succinic acid dimethyl ester in rat hepatocytes. |
| PubMed: | Metabolism of the dimethyl ester of [2,3-(13)C]succinic acid in rat hepatocytes. |
| PubMed: | Synthesis and 31P chemical shift identification of tripeptide active site models that represent human serum acetylcholinesterase covalently modified at serine by certain organophosphates. |
| PubMed: | NADP-malate dehydrogenase activity in rat erythrocytes. Comparison with pyruvate kinase in relation to coupling with lactate dehydrogenase. |
| PubMed: | Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion. |
| PubMed: | Counteractive Effects of ABA and GA3 on Extracellular and Intracellular pH and Malate in Barley Aleurone. |
| PubMed: | Tri-Calciphor (16,16-dimethyl-15-dehydroprostaglandin B1 trimer)-mediated mitochondrial Ca2+ movements: modulation by phosphate. |
| PubMed: | Metabolism of the insulin secretagogue methyl succinate by pancreatic islets. |
| PubMed: | Genetic and physiological characterization of the Rhodospirillum rubrum carbon monoxide dehydrogenase system. |
| PubMed: | Mechanisms involved in aggravation of ethanol-induced gastric mucosal lesions in adrenalectomized rats. |
| PubMed: | 12(R)-hydroxyeicosatrienoic acid: a vasodilator cytochrome P-450-dependent arachidonate metabolite from the bovine corneal epithelium. |
| PubMed: | Hydralazine-dependent carbon dioxide free radical formation by metabolizing mitochondria. |
| PubMed: | Biochemical alterations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors from rats subjected to caloric restriction. |
| PubMed: | Equilibrium constants of several reactions involved in the fermentation of glutamate. |
| PubMed: | An improved method for the preparation of rat brain microsomes. |
| PubMed: | Effects of glutathione depletion on gluconeogenesis in isolated hepatocytes. |
| PubMed: | Methyl parathion (O-O-dimethyl O-4-nitrophenyl thiophosphate) effects on whole-body and tissue respiration in the teleost, Tilapia mossambica (Peters). |
| PubMed: | Completion of the degradation scheme for nicotinic acid by Clostridium barkeri. |
| PubMed: | Nicotinic acid metabolism. Dimethylmaleate hydratase. |
| PubMed: | AMP-dependence of the cyanide-insensitive pathway in the respiratory chain of Paramecium tetraurelia. |
| PubMed: | Gluconeogenesis in rat hepatocytes from monomethyl succinate and other esters. |
| PubMed: | Nicotinic acid metabolism: stereochemical course of the (2R,3S)-2,3-dimethylmalate lyase reaction. |
| PubMed: | Fermentation and anaerobic respiration by Rhodospirillum rubrum and Rhodopseudomonas capsulata. |
| PubMed: | Effects of N-dimethyl propranolol (UM-272) on isolated cardiac mitochondria and microsomes. |
| PubMed: | pH and bicarbonate effects on mitochondrial anion accumulation. Proposed mechanism for changes in renal metabolite levels in acute acid-base disturbances. |
| PubMed: | Light versus Dark Carbon Metabolism in Cherry Tomato Fruits: II. Relationship Between Malate Metabolism and Photosynthetic Activity. |
| PubMed: | [Change in lipid-protein interactions in the membranes of bacteria exposed to gramicidin S]. |
| PubMed: | Intracellular pH of Thermoplasma acidophila. |
|