Articles:
| None found yet. Try the PubMed Search. |
methylene chloride
Notes:
a chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. its primary use is as a solvent in manufacturing and food technology. Used as an extraction solv. in the preparation of decaffeinated coffee, hop extracts and spice oleoresins. Diluent for colour additives and inks for marking fruit and vegetables
The output of these processes is a mixture of methyl chloride, dichloromethane, chloroform, and carbon tetrachloride. These compounds are separated by distillation.
-
American International Chemical, Inc. Consistent sources North American supplier for globally sourced ingredients. AIC is a Westborough, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of Sales Representatives, along with our network of strategically located warehouses are ready to supply product when and where you need it. Email: Info Voice: (800) 238-0001 Facebook Twitter Linkedin Products List: View Product(s): DH3842 Dichloromethane Anhydrosolv DB2795 Dichloromethane Biotech Grade
-
-
ECSA Chemicals Human Chemistry ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide. ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators. Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials. Email: Info Email: Sales Email: Trading Email: Maintenance Email: Energy Voice: +41 91 695 88 00 Fax: +41 91 695 88 01 Linkedin Youtube RSS Feed ECSA Trade ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY Products List: View Product(s): MP-010496 METHYLENE CHLORIDE 98/100 % RE-412622 DICHLOROMETHANE RS-FOR HPLC-ISOCRATIC GRADE- RE-442292000 DICHLOROMETHANE RS-PLUS-FOR RESIDUAL PESTICI RE-463311 DICHLOROMETHANE RPE-ACS-FOR ANALYSIS-REAG. P RE-463314 DICHLOROMETHANE RPE-ACS-FOR ANALYSIS-REAG. P
-
-
Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GK9913 Dichloromethane
-
| CAS Number: | 75-09-2 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 200-838-9 | |
| FDA UNII: | 588X2YUY0A | |
| Nikkaji Web: | J2.389B | |
| Beilstein Number: | 1730800 | |
| MDL: | MFCD00000881 | |
| XlogP3-AA: | 1.50 (est) | |
| Molecular Weight: | 84.93094000 | |
| Formula: | C H2 Cl2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: extraction solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.32500 @ 25.00 °C. |
| Boiling Point: | 40.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 435.000000 mmHg @ 25.00 °C. |
| logP (o/w): | 1.250 |
| Soluble in: | |
| alcohol | |
| ether | |
| water, 1.095e+004 mg/L @ 25 °C (est) | |
| water, 1.30E+04 mg/L @ 25 °C (exp) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
solvents |
Suppliers:
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-rat LD50 1600 mg/kg BEHAVIORAL: ATAXIA FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 94, 1970. intraperitoneal-rat LD50 916 mg/kg Environmental Research. Vol. 40, Pg. 411, 1986. intraperitoneal-dog LD50 1274 mg/kg Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967. intravenous-dog LDLo 200 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. oral-dog LDLo 3000 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. oral-human LDLo 357 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) PERIPHERAL NERVE AND SENSATION: PARESTHESIS "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 390, 1969. oral-man TDLo 1429 uL/kg BLOOD: NORMOCYTIC ANEMIA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 575, 1994. intraperitoneal-mouse LD50 437 mg/kg Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 18, Pg. 109, 1960. oral-mouse LD50 873 mg/kg EHP, Environmental Health Perspectives. Vol. 106(Suppl unreported-mouse LD50 4770 mg/kg GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH Eisei Kagaku. Hygienic Chemistry. Vol. 28, Pg. P31, 1982. unreported-rabbit LD50 1225 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988. oral-rabbit LDLo 1900 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 94, 1955. unreported-rat LD50 5350 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988. intratracheal-rat LDLo 350 mg/kg LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI National Technical Information Service. Vol. OTS0520615 | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 6460 mg/kg Toxicology and Applied Pharmacology. Vol. 4, Pg. 354, 1962. subcutaneous-rabbit LDLo 2700 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. | |
| Inhalation Toxicity: | |
|
inhalation-rat LC50 52 gm/m3 Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 64, 1979. inhalation-cat LCLo 43400 mg/m3/4. BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: ATAXIA Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936. inhalation-dog LCLo 14108 ppm/7H SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949. inhalation-guinea pig LCLo 5000 ppm/2H Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967. inhalation-human TCLo 500 ppm/1Y-I BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) CARDIAC: CHANGE IN RATE Abstracts on Hygiene. Vol. 43, Pg. 1123, 1968. inhalation-human TCLo 500 ppm/8H BEHAVIORAL: EUPHORIA Science. Vol. 176, Pg. 295, 1972. inhalation-mouse LC50 14400 ppm/7H National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949. inhalation-rabbit LCLo 10000 ppm/7H Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 8, 1944. inhalation-rat LC50 52000 mg/m3 Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 64, 1979. | |
Safety in Use Information:
| Category: | extraction solvents | ||
| Recommendation for dichloromethane usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for dichloromethane flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| EPA-Iris: | IRIS |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| NIOSH International Chemical Safety Cards: | search |
| NIOSH Pocket Guide: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 75-09-2 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6344 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| dichloromethane | |
| Chemidplus: | 0000075092 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 75-09-2 |
References:
| dichloromethane | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 75-09-2 |
| Pubchem (cid): | 6344 |
| Pubchem (sid): | 134970738 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| UM BBD: | Search |
| KEGG (GenomeNet): | C02271 |
| HMDB (The Human Metabolome Database): | HMDB31548 |
| FooDB: | FDB008159 |
| Export Tariff Code: | 2903.12.0000 |
| Wikipedia: | View |
| Formulations/Preparations: •dichloromethane is available as commercialtechnical grade & grades intended specifically for vapor degreasing, aerosol use, food extraction, reagent use & spectrophotometry. purity, when reported, ranges from 99-99.9% (reagenthigh performance liq chromatography grade). acidity (as hydrochloric acid) may be up to 5-10 mgkg. the max concn of water in commercial grade dichloromethane is generally 100-200 mgkg, but anhydrous dichloromethane (less than 50 mgkg water) is also available ... •small amt of stabilizers are often added to dichloromethane at the time of manufacture. cyclohexane (50 mgkg) & propylene oxide have been added to commercial aerosols & reagent grades of dichloromethane for this purpose. other reported stabilizers include 2-methyl-2-butene @ 50 mgkg, ethanol or methanol at approx 0.2%, & small quantities (1 mgkg) of phenol . •additives may include 0.0001-1% of stabilizers such as: amines, 4-cresol, hydroquinone, methanol, 2-methylbut-2-ene, 1-naphthol, nitromethane + 1,4-dioxane, phenol, resorcinol, and thymol. •in the usa, a standard grade dichloromethane has the following typical specifications: a clear, water white liquid, free of suspended matter acidity, 5 mgkg max; non volatile residue 10 mgkg max; free halogen none; & a 100% distillation range of 39.5-40.5 deg c. •grades available from mallinkrodt speciaty chemicals include ar, chomar, nanograde, spectrar, ultimar, acs reagent, usp, hplc, and gc grades. | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| aerothene MM | |
| methylene chloride | |
| narkotil | |
| solmethine | |
| methylene bichloride | |
| methylene dichloride | |
| methylenum chloratum |