Articles:
| None found yet. Try the PubMed Search. |
21-hydroxy-pregn-4-ene-3,20-dione
Notes:
desoxycorticosterone acetate (doca) is used as replacement therapy in addison disease. Deoxycorticosterone is a steroid or mineralocorticoid secreted by the zona fasiculata of the adrenal cortex. Deoxycorticsterone acts as a precursor to aldosterone. Deoxycorticosterone is not a major secretory hormone. It is produced from progesterone by 21beta-hydroxylase and is converted to corticosterone by 11beta-hydroxylase. Corticosterone is then converted to aldosterone by aldosterone synthase. Deoxycorticosterone stimulates the collecting tubules in the kidney to continue to excrete potassium in much the same way that aldosterone does. Deoxycorticosterone has about 1/20 of the sodium retaining power of aldosterone and about 1/5 the potassium excreting power of aldosterone [Wikipedia]. Deoxycorticosterone can be used to treat adrenal insufficiency. In particular, desoxycorticosterone acetate (DOCA) is used as replacement therapy in Addison's disease. [HMDB]
-
Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 04-06100 DESOXYCORTICOSTERONE
-
| CAS Number: | 64-85-7 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 200-596-4 | |
| FDA UNII: | 40GP35YQ49 | |
| Nikkaji Web: | J1.407I | |
| Beilstein Number: | 2062123 | |
| MDL: | MFCD00003661 | |
| XlogP3: | 2.90 (est) | |
| Molecular Weight: | 330.46770000 | |
| Formula: | C21 H30 O3 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 141.50 °C. @ 760.00 mm Hg |
| Boiling Point: | 488.02 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 505.00 °F. TCC ( 263.10 °C. ) (est) |
| logP (o/w): | 2.880 |
| Soluble in: | |
| water, 59.5 mg/L @ 37 °C (exp) | |
| water, 91.16 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Penta International |
| DESOXYCORTICOSTERONE |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 21-Hydroxyprogesterone |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| 21-Hydroxyprogesterone ≥97% (HPLC) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
unreported-mouse LD50 1000 mg/kg Journal of Medicinal Chemistry. Vol. 7, Pg. 673, 1964. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for desoxycorticosterone usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for desoxycorticosterone flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 6166 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| (8S,9S,10R,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| Chemidplus: | 0000064857 |
| RTECS: | HG0350000 for cas# 64-85-7 |
References:
| (8S,9S,10R,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 6166 |
| Pubchem (sid): | 134972466 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C03205 |
| HMDB (The Human Metabolome Database): | HMDB00016 |
| FooDB: | FDB021873 |
| Export Tariff Code: | 2937.29.0050 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| found in nature |
Synonyms:
| cortexone | |
| corticosterone, 11-deoxy- | |
| 11- | dehydroxycorticosterone |
| 11- | deoxy-corticosterone |
| 1,2(3H)- | deoxycorticosterone |
| 11- | deoxycorticosterone |
| desossicortone | |
| desoxicortonum | |
| 11- | desoxycorticosterone |
| desoxycorticosteronum | |
| desoxycortonum | |
| dorcostrin | |
| 21- | hydroxy-3,20-dioxopregn-4-ene |
| 21- | hydroxy-D4-pregnane-3,20-dione |
| 21- | hydroxy-pregn-4-ene-3,20-dione |
| 21- | hydroxy-progesterone |
| (8S,9S,10R,13S,14S,17S)-17-(2- | hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| 21- | hydroxypregn-4-ene-3,20-dione |
| kendall's desoxy compound B | |
| pregn-4-ene-3,20-dione, 21-hydroxy- | |
| D4- | pregnene-21-ol-3,20-dione |
| progesterone, 21-hydroxy- | |
| reichstein Q | |
| reichstein's substance Q | |
| undocan |