D-glucurono-6,3-lactone participates in ascorbate and aldarate metabolism. D-glucurono-6,3-lactone is produced by the reaction between D-glucaric acid and the enzyme, aldehyde dehydrogenase (NAD+) [EC:]. [HMDB]
  • BOC Sciences
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      G0055 D-Glucurono-6,3-lactone >99.0%(T)
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CAS Number: 32449-92-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 251-053-3
Nikkaji Web: J3.805I
Beilstein Number: 0083595
MDL: MFCD00135622
XlogP3-AA: -1.80 (est)
Molecular Weight: 176.12496000
Formula: C6 H8 O6
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 174.00 to  178.00 °C. @ 760.00 mm Hg
Boiling Point: 403.00 to  404.00 °C. @ 760.00 mm Hg
Flash Point: 346.00 °F. TCC ( 174.44 °C. )
logP (o/w): -3.457 (est)
Soluble in:
 water, 257000 mg/L @ 21C (exp)
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Organoleptic Properties:
Odor Type: mentholic
Odor Strength: low
Odor Description:
at 100.00 %. 
very mild mentholic
Odor and/or flavor descriptions from others (if found).
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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BOC Sciences
For experimental / research use only.
For experimental / research use only.
Charkit Chemical
EMD Millipore
For experimental / research use only.
Foodchem International
D-Glucurolactone 99% min. CP
Santa Cruz Biotechnology
For experimental / research use only.
D-Glucurono-3,6-lactone ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
D-(+)-Glucuronic acid gamma-lactone ≥99%
For experimental / research use only.
D-Glucurono-6,3-lactone >99.0%(T)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  10700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-rat LD50  3200 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-rabbit LD50  940 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

oral-mouse LD50  > 20000 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-mouse LD50  4568 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intraperitoneal-mouse LD50  5797 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

intravenous-dog LD50  940 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

Dermal Toxicity:
subcutaneous-rat LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-rabbit LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-mouse LD50 8210 ul/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-cat LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

subcutaneous-dog LD50 4700 mg/kg
Drugs in Japan Vol. 6, Pg. 225, 1982.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: special dietary and nutritional additives
Recommendation for dextro-glucurolactone usage levels up to:
 not for fragrance use.
Recommendation for dextro-glucurolactone flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks
View page or View pdf
Gathering consumption data on specific consumer groups of energy drinks
View page or View pdf
Scientific Opinion on the safety of caffeine
View page or View pdf
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 32449-92-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 92283
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
Chemidplus: 0032449926
RTECS: LZ8930000 for cas# 32449-92-6
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 32449-92-6
Pubchem (cid): 92283
Pubchem (sid): 135048564
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
Golm Metabolome Database: Search
KEGG (GenomeNet): C02670
HMDB (The Human Metabolome Database): HMDB06355
FooDB: FDB023903
Export Tariff Code: 2932.29.5050
FDA Listing of Food Additive Status: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
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Potential Blenders and core components note
None Found
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Potential Uses:
 skin conditioning 
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Occurrence (nature, food, other): note
 found in nature
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D-glucuronic acid lactone
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