|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 676.49 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 685.00 °F. TCC ( 362.90 °C. ) (est)
|
| logP (o/w): | 4.758 (est) |
| Soluble in: |
| | water, 0.018 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-chicken LD50 12500 ug/kg Canadian Journal of Microbiology. Vol. 22, Pg. 1137, 1976.
intraperitoneal-mammal (species unspecified) LD50 2341 ug/kg BEHAVIORAL: ATAXIA
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Indian Drugs. Vol. 15, Pg. 76, 1978.
intravenous-mouse LD50 2 mg/kg "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 2, Pg. 439, 1980.
unreported-mouse LDLo 2 mg/kg Japanese Journal of Experimental Medicine. Vol. 48, Pg. 105, 1978.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for cytochalasin H usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for cytochalasin H flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (11) | cytochalasa-6(12),13,19-trien-1-one, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18S,19E,21R)- | | | kodocytochalasin-1 | | | paspalin |
Articles:
| PubMed: | Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis. |
| PubMed: | Cytochalasin H, an active anti-angiogenic constituent of the ethanol extract of Gleditsia sinensis thorns. |
| PubMed: | Polar auxin transport in relation to long-distance transport of nutrients in the Charales. |
| PubMed: | A novel phytotoxic nonenolide from Phomopsis sp. HCCB03520. |
| PubMed: | Ep-oxy-cytochalasin H methanol solvate. |
| PubMed: | Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa. |
| PubMed: | Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines. |
| PubMed: | 1H and 13C NMR assignments of three nitrogen containing compounds from the mangrove endophytic fungus (ZZF08). |
| PubMed: | Changes in secondary metabolism during stromatal ontogeny of Hypoxylon fragiforme. |
| PubMed: | Effects of cytochalasin H, a potent inhibitor of cytoskeletal reorganisation, on platelet function. |
| PubMed: | New botrydial sesquiterpenoids from Hymenoscyphus epiphyllus. |
| PubMed: | Endocytosis of GPI-anchored proteins in human lymphocytes: role of glycolipid-based domains, actin cytoskeleton, and protein kinases. |
| PubMed: | L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. II. Isolation and structure. |
| PubMed: | L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. I. The producing organism and its fermentation. |
| PubMed: | Effects of cytochalasin H on chick embryo explants cultured in vitro. |
| PubMed: | Effect of cytochalasins B & H on isoelectric focusing of chick embryonic neural retina cells. |
| PubMed: | Correlation between effects of 24 different cytochalasins on cellular structures and cellular events and those on actin in vitro. |
| PubMed: | Inhibitory effect of cytochalasin H on cell reaggregation of the fresh water sponge, Ephydatia meyeni Carter. |
| PubMed: | The actions of various cytochalasins on mouse adrenal tumor cells in relation to trophic stimulation of steroidogenesis. |
| PubMed: | Ultrastructural changes in the embryonic cells of the frog Microhyla ornata after cytochalasin H treatment. |
| PubMed: | Effects of cytochalasin H on human lymphocyte cultures. |
| PubMed: | Effects of cytochalasin H on the morphogenetic movements of the embryos of Microhyla ornata. |
| PubMed: | Effects of cytochalasin H on the embryonic endodermal cells of Microhyla ornata. |
| PubMed: | Structure of a new [11]cytochalasin, cytochalasin H or kodo-cytochalasin-1. |
| PubMed: | Toxicity and plant growth regulator effects of cytochalasin H isolated from Phomopsis sp. |
|