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Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 285.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 491.91 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 378.00 °F. TCC ( 192.50 °C. ) (est)
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| logP (o/w): | 3.520 |
| Soluble in: |
| | water, 84 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic agents |
| Recommendation for chrysin usage levels up to: | | | not for fragrance use.
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| Recommendation for chrysin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 5,7-dihydroxy-2-phenyl- | | 4H-1- | benzopyran-4-one, 5,7-dihydroxy-2-phenyl- (9CI) | | | chrysidenon 1438 | | 5,7- | dihydroxy-2-phenyl-4H-1-benzopyran-4-one | | 5,7- | dihydroxy-2-phenyl-4H-benzo(b)pyran-4-one | | 5,7- | dihydroxy-2-phenyl-4H-chromen-4-one | | 5,7- | dihydroxy-2-phenyl-chromen-4-one | | 5,7- | dihydroxy-2-phenylchromen-4-one | | 5,7- | dihydroxy-flavone | | 5,7- | dihydroxyflavone | | | galangin flavanone | | 5,7- | hydroxyflavone |
Articles:
| PubMed: | Chemical Composition of the Essential Oils of Three Endemic Species of Anthemis Sect. Hiorthia (DC.) R.Fern. Growing Wild in Sicily and Chemotaxonomic Volatile Markers of the Genus Anthemis L.: An Update. |
| PubMed: | Anthelmintic activity of crude extract and essential oil of Tanacetum vulgare (Asteraceae) against adult worms of Schistosoma mansoni. |
| PubMed: | TLC-direct bioautography for determination of antibacterial activity of Artemisia adamsii essential oil. |
| PubMed: | Central α- and β-thujone: similar anxiogenic-like effects and differential modulation on GABAA receptors in neonatal chicks. |
| PubMed: | Chemical characterization by GC-MS and in vitro activity against Candida albicans of volatile fractions prepared from Artemisia dracunculus, Artemisia abrotanum, Artemisia absinthium and Artemisia vulgaris. |
| PubMed: | Chemical composition and general toxicity of essential oils extracted from the aerial parts of Artemisia armeniaca Lam. and A. incana (L.) Druce growing in Iran. |
| PubMed: | Chemotype diversity of indigenous Dalmatian sage (Salvia officinalis L.) populations in Montenegro. |
| PubMed: | Differences in shoot and root terpenoid profiles and plant responses to fertilisation in Tanacetum vulgare. |
| PubMed: | Study on Gas Chromatography-Mass Spectrometry Fingerprint of Acanthopanax brachypus. |
| PubMed: | Chemopreventive and antioxidant activity of the chamazulene-rich essential oil obtained from Artemisia arborescens L. growing on the Isle of La Maddalena, Sardinia, Italy. |
| PubMed: | Comparison of different extraction methods for the determination of α- and β-thujone in sage (Salvia officinalis L.) herbal tea. |
| PubMed: | Toxicokinetics of α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice. |
| PubMed: | Identification of 1,8-cineole, borneol, camphor, and thujone as anti-inflammatory compounds in a Salvia officinalis L. infusion using human gingival fibroblasts. |
| PubMed: | Identification of genes in Thuja plicata foliar terpenoid defenses. |
| PubMed: | Attempts to separate (-)-α-thujone, (+)-β-thujone epimers from camphor enantiomers by enantioselective HPLC with polarimetric detection. |
| PubMed: | Monoterpene α-thujone exerts a differential inhibitory action on GABA(A) receptors implicated in phasic and tonic GABAergic inhibition. |
| PubMed: | Antibacterial, allelopathic and antioxidant activities of essential oil of Salvia officinalis L. growing wild in the Atlas Mountains of Morocco. |
| PubMed: | Thujone and thujone-containing herbal medicinal and botanical products: toxicological assessment. |
| PubMed: | Essential oil variation in the populations of Artemisia spicigera from northwest of Iran: chemical composition and antibacterial activity. |
| PubMed: | Essential oils and their compositions as spatial repellents for pestiferous social wasps. |
| PubMed: | Chemical composition and antimicrobial activity of essential oils from Scabiosa arenaria Forssk: growing wild in Tunisia. |
| PubMed: | Modulation of GABAergic synaptic currents and current responses by α-thujone and dihydroumbellulone. |
| PubMed: | Chemical composition and antifungal activity of Artemisia nilagirica essential oil growing in northern hilly areas of India. |
| PubMed: | Composition of the essential oil of Origanum tyttanthum from Tajikistan. |
| PubMed: | Seasonal influence on gene expression of monoterpene synthases in Salvia officinalis (Lamiaceae). |
| PubMed: | Toxicology and carcinogenesis studies of alpha,beta-thujone (CAS No. 76231-76-0) in F344/N rats and B6C3F1 mice (gavage studies). |
| PubMed: | Distribution and chemical polymorphism of the essential oils of Achillea cartilaginea growing wild in Lithuania. |
| PubMed: | Thujone inhibits lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. |
| PubMed: | Augmentation of humoral and cell mediated immune responses by Thujone. |
| PubMed: | Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.). |
| PubMed: | Thujone corrects cholesterol and triglyceride profiles in diabetic rat model. |
| PubMed: | Modulation of genotoxicity and DNA repair by plant monoterpenes camphor, eucalyptol and thujone in Escherichia coli and mammalian cells. |
| PubMed: | Skeletal muscle fatty acid oxidation is not directly associated with AMPK or ACC2 phosphorylation. |
| PubMed: | Morphological characterisation and agronomical parameters of different species of Salvia sp. (Lamiaceae). |
| PubMed: | Oil constituents of Artemisia nilagirica var. septentrionalis growing at different altitudes. |
| PubMed: | Chemical composition and antibacterial potential of Artemisia arborescens L. essential oil. |
| PubMed: | Metabolism of α-thujone in human hepatic preparations in vitro. |
| PubMed: | Composition and intraspecific chemical variability of the essential oil from Artemisia herba-alba growing wild in a Tunisian arid zone. |
| PubMed: | Influence of ionic interactions on essential oil and phenolic diterpene composition of Dalmatian sage (Salvia officinalis L.). |
| PubMed: | Insecticidal activity and chemical composition of the essential oils of Artemisia lavandulaefolia and Artemisia sieversiana from China. |
| PubMed: | Risk assessment of thujone in foods and medicines containing sage and wormwood--evidence for a need of regulatory changes? |
| PubMed: | Chemical composition of the essential oil of Salvia officinalis L. from Romania. |
| PubMed: | Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle. |
| PubMed: | Antimicrobial activity and essential oil composition of a new T. argyrophyllum (C. Koch) Tvzel var. argyrophyllum chemotype. |
| PubMed: | Essential oil composition of Achillea clusiana from Bulgaria. |
| PubMed: | Influence of gibberellin and daminozide on the expression of terpene synthases and on monoterpenes in common sage (Salvia officinalis). |
| PubMed: | Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-kappaB and MAPK activation in RAW 264.7 macrophages. |
| PubMed: | Antibacterial and antioxidant activities of the essential oil of Artemisia echegarayi Hieron. (Asteraceae). |
| PubMed: | Chemosystematic value of the essential oil composition of Thuja species cultivated in Poland-antimicrobial activity. |
| PubMed: | Variations in essential oil, phenolic compounds, and antioxidant activity of tunisian cultivated Salvia officinalis L. |
| PubMed: | Absinthe, epileptic seizures and Valentin Magnan. |
| PubMed: | Compositional variation of the essential oils of Artemisia afra Jacq. from three provinces in South Africa--a case study of its safety. |
| PubMed: | Motile cilia of human airway epithelia are chemosensory. |
| PubMed: | Essential oil composition of Tanacetum vulgare subsp. siculum (Guss.) Raimondo et Spadaro (Asteraceae) from Sicily. |
| PubMed: | Essential oil composition of Artemisia herba-alba from southern Tunisia. |
| PubMed: | Cytotoxicity, antimicrobial activity and composition of essential oil from Tanacetum balsamita L. subsp. balsamita. |
| PubMed: | Long-term stability of thujone, fenchone, and pinocamphone in vintage preban absinthe. |
| PubMed: | Chemical composition of the essential oil of Achillea umbellata growing in Greece. |
| PubMed: | Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone. |
| PubMed: | Chemical composition of the essential oil of Artemisia absinthium growing wild in Iran. |
| PubMed: | Tunisian Salvia officinalis L. and Schinus molle L. essential oils: their chemical compositions and their preservative effects against Salmonella inoculated in minced beef meat. |
| PubMed: | [Thujone-attributable effects of absinthe are only an urban legend--toxicology uncovers alcohol as real cause of absinthism]. |
| PubMed: | Chemical composition of vintage preban absinthe with special reference to thujone, fenchone, pinocamphone, methanol, copper, and antimony concentrations. |
| PubMed: | Tick repellent substances in the essential oil of Tanacetum vulgare. |
| PubMed: | [Thujone]. |
| PubMed: | Absinthe and tobacco--a new look at an old problem? (Comment on: Absinthe--is its history relevant for current public health?). |
| PubMed: | Insecticidal properties of essential oils from Lippia turbinata and Lippia polystachya (Verbenaceae) against Culex quinquefasciatus (Diptera: Culicidae). |
| PubMed: | [Chemical diversity of the biological active ingredients of salvia officinalis and some closely related species]. |
| PubMed: | [Absinthe - history of dependence to thujone or to alcohol?]. |
| PubMed: | Composition of the essential oil of Salvia officinalis L. from various European countries. |
| PubMed: | Chemical composition and antifungal activity of the essential oils of three species of Artemisia on some soil-borne phytopathogens. |
| PubMed: | The essential oil of Solvia cabulica. |
| PubMed: | Biotransformation of terpenoids by mammals, microorganisms, and plant-cultured cells. |
| PubMed: | Phytochemical analysis of the essential oil of Achillea millefolium L. from various European Countries. |
| PubMed: | Absinthe--a review. |
| PubMed: | Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its monoterpenes against UV-induced mutations in Escherichia coli and Saccharomyces cerevisiae. |
| PubMed: | Absinthe, the nervous system and painting. |
| PubMed: | Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes. |
| PubMed: | Vapor phase toxicity of marjoram oil compounds and their related monoterpenoids to Blattella germanica (Orthoptera: Blattellidae). |
| PubMed: | Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. |
| PubMed: | Thujone--cause of absinthism? |
| PubMed: | Absinthe: attention performance and mood under the influence of thujone. |
| PubMed: | Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae). |
| PubMed: | Alpha- and beta-thujone radical rearrangements and isomerizations. A new radical clock. |
| PubMed: | Radical rebound mechanism in cytochrome P-450-catalyzed hydroxylation of the multifaceted radical clocks alpha- and beta-thujone. |
| PubMed: | The human taste receptor hTAS2R14 responds to a variety of different bitter compounds. |
| PubMed: | Chemotypical variation of tansy (Tanacetum vulgare L.) from 40 different locations in Norway. |
| PubMed: | Alpha-thujone reduces 5-HT3 receptor activity by an effect on the agonist-reduced desensitization. |
| PubMed: | GC analysis of essential oils in the rumen fluid after incubation of Thuja orientalis twigs in the Rusitec system. |
| PubMed: | Plant odour processing in the antennal lobe of male and female grapevine moths, Lobesia botrana (Lepidoptera: Tortricidae). |
| PubMed: | Volatile metabolites from Salvia fruticosa as antifungal agents in soilborne pathogens. |
| PubMed: | Essential oils produced by in vitro shoots of sage (Salvia officinalis L.). |
| PubMed: | Composition and antimicrobial activity of the essential oil of Artemisia absinthium from Croatia and France. |
| PubMed: | [Studies of volatile oils from the flowers of Chrysanthemum nankingense and Chrysanthemum indicum]. |
| PubMed: | Monoterpene effect on feeding choice by deer. |
| PubMed: | Absinthe: enjoying a new popularity among young people? |
| PubMed: | Composition and antimicrobial activity of the essential oil of Achillea multifida. |
| PubMed: | Absinthe: return of the Green Fairy. |
| PubMed: | Seasonal changes in the composition of the essential oil extract of East Mediterranean sage (Salvia libanotica) and its toxicity in mice. |
| PubMed: | Detoxification of alpha- and beta-Thujones (the active ingredients of absinthe): site specificity and species differences in cytochrome P450 oxidation in vitro and in vivo. |
| PubMed: | Towards the industrial production of medicinal tincture by ultrasound assisted extraction. |
| PubMed: | alpha- and beta-Thujones (herbal medicines and food additives): synthesis and analysis of hydroxy and dehydro metabolites. |
| PubMed: | Acaricidal properties of Artemisia absinthium and Tanacetum vulgare (Asteraceae) essential oils obtained by three methods of extraction. |
| PubMed: | Absinthe and gamma-aminobutyric acid receptors. |
| PubMed: | Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. |
| PubMed: | Absinthe: what's your poison? Though absinthe is intriguing, it is alcohol in general we should worry about. |
| PubMed: | Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites. |
| PubMed: | Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses. |
| PubMed: | Absinthe--return of the green fairy. |
| PubMed: | Comparison of conventional and ultrasonically assisted extractions of pharmaceutically active compounds from Salvia officinalis. |
| PubMed: | Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for absinthe and the illness of Vincent van Gogh). |
| PubMed: | Floral volatiles ofTanacetum vulgare L. attractive toLobesia botrana den. et schiff. females. |
| PubMed: | Volatile Constituents of Achillea grandifolia. |
| PubMed: | Another diagnosis for Vincent Van Gogh? |
| PubMed: | Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (+-)-7-hydroxycitronellal, citral, (-)-perillaldehyde, (-)-myrtenal, cuminaldehyde, thujone, and (+-)-carvone in rabbits. |
| PubMed: | Absinthe. |
| PubMed: | Vincent van Gogh and the thujone connection. |
| PubMed: | Metabolism of monoterpenes: specificity of the dehydrogenases responsible for the biosynthesis of camphor, 3-thujone, and 3-isothujone. |
| PubMed: | A study on tansy chemotypes. |
| PubMed: | Isolation and identification of mosquito repellents inArtemisia vulgaris. |
| PubMed: | Quantitative analysis of alpha, beta-thujone, pulegone, safrole, coumarin and beta-asarone in alcoholic beverages by selected-ion monitoring. |
| PubMed: | Constituents of the Essential Oil of Artemisia coerulescens. |
| PubMed: | [Condensation of thujone with biogenic amines and amino acids]. |
| PubMed: | Absinthe: behind the emerald mask. |
| PubMed: | Van Gogh's vision: thujone intoxication. |
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