Articles:
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5-chloro-2-hydroxybenzoxazole
Notes:
a centrally acting central muscle relaxant with sedative properties. it is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (from martindale, the extra pharmacopoea, 30th ed, p1202)
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| CAS Number: | 95-25-0 |  3D/inchi
|
| Other(deleted CASRN): | 32850-84-3 | |
| ECHA EINECS - REACH Pre-Reg: | 202-403-9 | |
| FDA UNII: | H0DE420U8G | |
| Nikkaji Web: | J3.950K | |
| MDL: | MFCD00005717 | |
| XlogP3: | 1.80 (est) | |
| Molecular Weight: | 169.56628000 | |
| Formula: | C7 H4 Cl N O2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 191.50 °C. @ 760.00 mm Hg |
| Boiling Point: | 336.90 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000056 mmHg @ 25.00 °C. (est) |
| Flash Point: | 316.00 °F. TCC ( 157.50 °C. ) (est) |
| logP (o/w): | 1.816 (est) |
| Soluble in: | |
| water, 2709 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Chlorzoxazone >98%
Odor: characteristic Use: Chlorzoxazone is a muscle-relaxing drug, and a probe for human liver cytochrome P-450IIE1. |
| Glentham Life Sciences |
| Chlorzoxazone |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Chlorzoxazone |
| TCI AMERICA |
| For experimental / research use only. |
| Chlorzoxazone >98.0%(GC)(T) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-hamster LD50 166 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ATAXIA Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. oral-hamster LD50 662 mg/kg BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. intraperitoneal-mammal (species unspecified) LD50 550 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Chimica Therapeutica. Vol. 6, Pg. 65, 1971. oral-man TDLo 50 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: COMA American Journal of Emergency Medicine. Vol. 16, Pg. 393, 1998. intraperitoneal-mouse LD50 50 mg/kg National Technical Information Service. Vol. AD277-689 oral-mouse LD50 440 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 242, 1967. intraperitoneal-rat LD50 150 mg/kg BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. oral-rat LD50 763 mg/kg BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 75, 1960. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 170 mg/kg BEHAVIORAL: ANTICONVULSANT Acta Pharmacologica et Toxicologica. Vol. 19, Pg. 247, 1962. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for chlorzoxazone usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for chlorzoxazone flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 95-25-0 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 2733 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 5-chloro-3H-1,3-benzoxazol-2-one | |
| Chemidplus: | 0000095250 |
| RTECS: | DM5250000 for cas# 95-25-0 |
References:
| 5-chloro-3H-1,3-benzoxazol-2-one | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 95-25-0 |
| Pubchem (cid): | 2733 |
| Pubchem (sid): | 134971727 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C07931 |
| HMDB (The Human Metabolome Database): | HMDB14500 |
| Export Tariff Code: | 2934.99.4400 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| 2- | benzoxazolinone, 5-chloro- |
| 2- | benzoxazolol, 5-chloro- |
| 2(3H)- | benzoxazolone, 5-chloro- |
| 5- | chlorbenzoxazolin-2-one |
| 5- | chloro-1,3-benzoxazol-2(3H)-one |
| 5- | chloro-2-benzoxazolinone |
| 5- | chloro-2-hydroxybenzoxazole |
| 5- | chloro-2,3-dihydro-2-oxo-1,3-benzoxazole |
| 5- | chloro-2(3H)-benzoxazolone |
| 5- | chloro-3-hydrobenzoxazol-2-one |
| 5- | chloro-3(H)-2-benzoxazolone |
| 5- | chloro-3H-1,3-benzoxazol-2-one |
| 5- | chloro-3H-benzooxazol-2-one |
| 5- | chloro-3H-benzoxazol-2-one |
| 5- | chloro-benzooxazol-2-ol |
| 5- | chlorobenzoxazol-2-one |
| 5- | chlorobenzoxazolidone |
| 5- | chlorobenzoxazolin-2-one |
| chloroxazone | |
| chlorsoxazone | |
| chlorzoxane | |
| chlorzoxazon | |
| 2- | hydroxy-5-chlorobenzoxazole |
| myoflexin | |
| myoflexine | |
| neoflex | |
| paraflex | |
| parafon | |
| pathorysin | |
| relaxazone | |
| solaxin |