hydrochlorofluorocarbon 22
chlorodifluoromethane
 
Notes:
None found
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CAS Number: 75-45-6Picture of molecule3D/inchi
Other: 134191-96-1
ECHA EINECS - REACH Pre-Reg: 200-871-9
FDA UNII: ZFO627O6CN
Nikkaji Web: J1.455I
Beilstein Number: 1731036
MDL: MFCD00000821
XlogP3-AA: 1.80 (est)
Molecular Weight: 86.46777640
Formula: C H Cl F2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: propellants, aerating agents, and gas
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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DG SANTE Food Contact Materials: chlorodifluoromethane
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Physical Properties:
Appearance: colorless gas (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: -157.42 °C. @ 760.00 mm Hg (est)
Boiling Point: -38.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 7250.000000 mmHg @ 25.00 °C. (est)
Vapor Density: 3 ( Air = 1 )
Flash Point: -129.00 °F. TCC ( -89.40 °C. ) (est)
logP (o/w): 1.080
Soluble in:
 water, 2770 mg/L @ 25 °C (exp)
 water, 2748 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: propellants
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD  > 43200 ug/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(8), Pg. 69, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-dog LCLo 70 pph
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Toxicology and Applied Pharmacology. Vol. 2, Pg. 363, 1960.

inhalation-guinea pig LCLo 30 pph/2H
BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. Vol. 21, Pg. 149, 1971.

inhalation-mouse LC50 1380000 mg/m3/2H
LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Vol. 75, Pg. 241, 1963.

inhalation-rat LC50 35 pph/15M
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: ATAXIA
Human Toxicology. Vol. 1, Pg. 239, 1982.

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Safety in Use Information:
Category: propellants, aerating agents, and gas
Recommendation for hydrochlorofluorocarbon 22 usage levels up to:
 not for fragrance use.
 
Recommendation for hydrochlorofluorocarbon 22 flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ECHA (ESR): View
EPA-Iris: IRIS
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 75-45-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6372
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 chloro(difluoro)methane
Chemidplus: 0000075456
EPA/NOAA CAMEO: hazardous materials
RTECS: 75-45-6
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References:
 chloro(difluoro)methane
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 75-45-6
Pubchem (cid): 6372
Pubchem (sid): 134970901
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C19361
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2903.40.0010
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
•usepaopp pesticide code 000015; trade names: freon 22. former trade names •grade: technical; 99.9% pure •it is available as a liquified gas in an azeotropic mixture of 48.8% chlorodifluoromethane with 51.2% chloropentafluoroethane; this mixed gas is designated fluorocarbon-502 .
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 propellants 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 algeon 22
 algofrene 22
 algofrene type 6
 arcton 22
 arcton 4
 CFC 22
 chloro(difluoro)methane
 chlorodifluoromethane
mono-chlorodifluoromethane
 chlorodifluoromethane [R22] [UN1018] [Nonflammable gas]
 chlorofluorocarbon 22
 daiflon 22
 difluorochloromethane
 difluoromonochloromethane
 dymel 22
 electro-CF 22
 eskimon 22
 F 22 (halocarbon)
 FC 22
 FKW 22
 flugene 22
 fluorocarbon-22
 forane 22
 forane 22 B
 freon 22
 frigen 22
 genetron 22
 haltron 22
 HCFC 22
 HCFC-22
 HFA-22
 HSDB 143
 isceon 22
 isotron 22
 khladon 22
 methane, chlorodifluoro-
 propellant 22
 R 22 (refrigerant)
 racon 22
 refrigerant R 22
 ucon 22
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Articles:
PubMed: Asphyxiation fatality exposure from chlorodifluoromethane.
PubMed: Determination of partition coefficients of refrigerants by gas liquid chromatographic headspace analysis.
PubMed: High-temperature hydrodechlorination of ozone-depleting chlorodifluoromethane (HCFC-22) on supported Pd and Ni catalysts.
PubMed: The structure and interaction energies of the weak complexes of CHClF2 and CHF3 with HCCH: a test of density functional theory methods.
PubMed: 'Virgin gas' ban demands user rethink.
PubMed: [Determination of chlorodifluoromethane in air of work places with gas chromatography].
PubMed: An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay.
PubMed: Difluoromethyltrialkylammonium salts--their expeditious synthesis from chlorodifluoromethane and tertiary amines in the presence of concentrated aqueous sodium hydroxide. The catalytic process.
PubMed: Simultaneous conversion of CHClF(2) and CH(3)Br to CH(2)CF(2).
PubMed: An accidental death due to Freon 22 (monochlorodifluoromethane) inhalation in a fishing vessel.
PubMed: Jet spectroscopy of arylmethyl radicals in the visible region: assignment of low-frequency vibrational modes in diphenylmethyl and chlorodiphenylmethyl radicals.
PubMed: Acute inhalational exposure to chlorodifluoromethane (freon-22): a report of 43 cases.
PubMed: Quantification of the refrigerants R22 and R134a in mixtures by means of different polymers and reflectometric interference spectroscopy.
PubMed: Inhalation of decomposed chlorodifluoromethane (freon-22) and myocardial infarction.
PubMed: Improper or classical hydrogen bonding? A comparative cryosolutions infrared study of the complexes of HCClF(2), HCCl(2)F, and HCCl(3) with dimethyl ether.
PubMed: [Measurement of chlorodifluoromethane(HCFC-22) in the atmosphere by using an O2-induced electron capture detector (ECD)].
PubMed: In situ X-ray diffraction and solid-state NMR study of the fluorination of gamma-Al(2)O(3) with HCF(2)Cl.
PubMed: A sensitive neutron dosimeter using superheated liquid.
PubMed: Formation of phosgene during welding activities in an atmosphere containing chlorinated hydrocarbons.
PubMed: Chlorodifluoromethane.
PubMed: Frigen II improves the reliability of measurement of interleukin-1 related substances in amniotic fluid.
PubMed: Facial injury and airway threat from inhalant abuse: a case report.
PubMed: Cryogen spray cooling during Nd:YAG laser treatment of hemangiomas. A preliminary animal model study.
PubMed: Nd:YAG laser irradiation in conjunction with cryogen spray cooling induces deep and spatially selective photocoagulation in animal models.
PubMed: The influence of sleeping position on functional residual capacity and effective pulmonary blood flow in healthy neonates.
PubMed: Headspace GC/MS testing for chlorodifluoromethane in two fatal cases.
PubMed: Secondary arterial hypertension linked to Freon exposure.
PubMed: Occupational phosgene poisoning: a case report and review.
PubMed: Evaluation of sampling and analytical methods for the determination of chlorodifluoromethane in air.
PubMed: Fatality due to recreational use of chlorodifluoromethane and chloropentafluoroethane.
PubMed: [Sudden death caused by freon 22?].
PubMed: Human inhalation pharmacokinetics of chlorodifluoromethane (HCFC22).
PubMed: Comparison of estimates of cardiac output by indicator dilution and freon 22 uptake during gas mixing in dogs.
PubMed: [Temperature profile in the enamel during cold tests].
PubMed: Behavioural thermoregulation in mice: effects of low doses of general anaesthetics of different potency.
PubMed: Acute toxicity of a nuclear magnetic resonance cerebral blood flow indicator in cats.
PubMed: Sloping alveolar plateaus of CO2, O2, and intravenously infused C2H2 and CHClF2 in the dog.
PubMed: Cooling rate and ice-crystal measurement in biological specimens plunged into liquid ethane, propane, and Freon 22.
PubMed: Expirograms of O2, CO2 and intravenously infused C2H2 and Freon-22 during panting in dogs.
PubMed: Cardiac arrhythmia in refrigerator repairmen exposed to fluorocarbons.
PubMed: Cardiac arrhythmias during occupational exposure to fluorinated hydrocarbons.
PubMed: Effects of environmental O2 on blood flow and diffusing capacity in amphibian skin.
PubMed: Solubility of Freon 22 in human blood and lung tissue.
PubMed: Solubility of freon-22 in blood and lung tissue.
PubMed: The sloping alveolar plateau of tracer gases washed out from mixed venous blood in man.
PubMed: Cerebral blood flow measured by NMR indicator dilution in cats.
PubMed: [A toxicological study of the effects of freon 22 inhalation--the behavior of rats exposed to freon inhalation and an evaluation of freon concentrations in their tissue].
PubMed: Elimination kinetics of acetylene and Freon 22 in resting and active lungless salamanders.
PubMed: Long-term carcinogenicity bioassays on three chlorofluorocarbons (trichlorofluoromethane, FC11; dichlorodifluoromethane, FC12; chlorodifluoromethane, FC22) administered by inhalation to Sprague-Dawley rats and Swiss mice.
PubMed: Diffusion-related differences in elimination of inert gases from the lung.
PubMed: Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22).
PubMed: Chlorodifluoromethane.
PubMed: The relevance for man of animal data on reproductive toxicity of industrial chemicals.
PubMed: [Effects of the use of FRIGEN (AG-Ffm-HOECST) on the determination of blood levels of some proteins (IgA, IgM, IgG, C3c, C4) in cord blood of healthy newborn infants at term by laser nephelometry].
PubMed: The toxicological evaluation of chlorofluorocarbon 22 (CFC 22).
PubMed: Role of diffusion-dependent gas inhomogeneity in gas exchange in the dog.
PubMed: Acute toxicity of fluorocarbon-22: toxic symptoms, lethal concentration, and its fate in rabbit and mouse.
PubMed: Studies on the male reproductive toxicity of Freon 22.
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