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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | yellw powder (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 58.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 325.68 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 364.00 °F. TCC ( 184.60 °C. ) (est)
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| logP (o/w): | 2.870 |
| Soluble in: |
| | water, 167.6 mg/L @ 25 °C (est) | | | water, 335 mg/L @ 25 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 67 mg/kg Journal of Medicinal Chemistry. Vol. 17, Pg. 900, 1974.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for butyl 4-aminobenzoate usage levels up to: | | | not for fragrance use.
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| Recommendation for butyl 4-aminobenzoate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4- | amino-benzoic acid butyl ester | | 4- | aminobenzoic acid butyl ester | | p- | aminobenzoic acid butyl ester | | 4- | aminobenzoic acid n-butyl ester | | p- | aminobenzoic acid, butyl ester | | | benzoic acid, 4-amino-, butyl ester | | | benzoic acid, p-amino-, butyl ester | | | butamben | | | butesin | | | butoform | | 4-( | butoxycarbonyl)aniline | | | butyl p-aminobenzoate | | N- | butyl p-aminobenzoate | | | butyl PABA | | | butyl-4-aminobenzoate | | N- | butyl-p-aminobenzoate | | | butylcaine | | | planoform | | | scuroform | | | zyljectin |
Articles:
| PubMed: | Modulation of peripheral Na(+) channels and neuronal firing by n-butyl-p-aminobenzoate. |
| PubMed: | The effect of oral topical anesthesia on the characteristics of voice. |
| PubMed: | Transdermal delivery of butamben using elastic and conventional liposomes. |
| PubMed: | Inhibition of sensory neuronal TRPs contributes to anti-nociception by butamben. |
| PubMed: | Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression. |
| PubMed: | New "drug-in cyclodextrin-in deformable liposomes" formulations to improve the therapeutic efficacy of local anaesthetics. |
| PubMed: | On the bioreactivity of triorganotin aminobenzoates. Investigation of trialkyl and triarylyltin(IV) esters of 3-amino and 4-aminobenzoic acids. |
| PubMed: | The local anesthetic butamben inhibits total and L-type barium currents in PC12 cells. |
| PubMed: | The local anesthetic butamben inhibits and accelerates low-voltage activated T-type currents in small sensory neurons. |
| PubMed: | Structural characteristics and crystal polymorphism of three local anaesthetic bases crystal polymorphism of local anaesthetic drugs: part VII. |
| PubMed: | Inhibition of the A-type K+ channels of dorsal root ganglion neurons by the long-duration anesthetic butamben. |
| PubMed: | The block of total and N-type calcium conductance in mouse sensory neurons by the local anesthetic n-butyl-p-aminobenzoate. |
| PubMed: | Analgesic synergy between topical morphine and butamben in mice. |
| PubMed: | Antifolate chemistry: synthesis of 4-[N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino]benzoic acid via a (propargyl)Co2(CO)6+ complex. |
| PubMed: | Analysis of a glucose tetrasaccharide elevated in Pompe disease by stable isotope dilution-electrospray ionization tandem mass spectrometry. |
| PubMed: | Purification and characterization of PrbA, a new esterase from Enterobacter cloacae hydrolyzing the esters of 4-hydroxybenzoic acid (parabens). |
| PubMed: | Kv1.1 channels of dorsal root ganglion neurons are inhibited by n-butyl-p-aminobenzoate, a promising anesthetic for the treatment of chronic pain. |
| PubMed: | Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors. |
| PubMed: | The antinociceptive and histologic effect of sciatic nerve blocks with 5% butamben suspension in rats. |
| PubMed: | Comparison of epidural butamben to celiac plexus neurolytic block for the treatment of the pain of pancreatic cancer. |
| PubMed: | Diffusion of n-butyl-p-aminobenzoate (BAB), lidocaine and bupivacaine through the human dura-arachnoid mater in vitro. |
| PubMed: | Orientations and locations of local anesthetics benzocaine and butamben in phospholipid membranes as studied by 2H NMR spectroscopy. |
| PubMed: | Identification of a yellow impurity in aged samples of aqueous butamben suspension: evidence for the oxidative degradation of poly(ethylene glycol). |
| PubMed: | Methemoglobinemia induced by topical anesthesia: a case report and review. |
| PubMed: | The long-term effect of epidural administration of butamben suspension on nerve injury-induced allodynia in rats. |
| PubMed: | Particle size determination of a flocculated suspension using a light-scattering particle size analyzer. |
| PubMed: | Nerve blocks with 5% butamben suspension for the treatment of chronic pain syndromes. |
| PubMed: | Partition coefficients (n-octanol/water) of N-butyl-p-aminobenzoate and other local anesthetics measured by reversed-phase high-performance liquid chromatography. |
| PubMed: | Epidural and intrathecal n-butyl-p-aminobenzoate solution in the rat. Comparison with bupivacaine. |
| PubMed: | The local anesthetic, n-butyl-p-aminobenzoate, reduces rat sensory neuron excitability by differential actions on fast and slow Na+ current components. |
| PubMed: | Characterization of site I on human serum albumin: concept about the structure of a drug binding site. |
| PubMed: | Analgesic efficacy of topical butamben picrate. |
| PubMed: | Capillary gas chromatographic method for the determination of n-butyl-p-aminobenzoate and lidocaine in plasma samples. |
| PubMed: | The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons. |
| PubMed: | Formulation factors affecting release of drug from topical vehicles. II. Effect of solubility on in vitro delivery of a series of n-alkyl p-aminobenzoates. |
| PubMed: | Long-lasting epidural sensory blockade by n-butyl-p-aminobenzoate in the terminally ill intractable cancer pain patient. |
| PubMed: | Preliminary study to assay plasma amethocaine concentrations after topical application of a new local anaesthetic cream containing amethocaine. |
| PubMed: | A 'forgotten' topical anaesthetic sensitizer: butyl aminobenzoate. |
| PubMed: | Butyl-p-aminobenzoate. Preparation, characterization and quality control of a suspension injection for epidural analgesia. |
| PubMed: | Long-lasting epidural sensory blockade by n-butyl p-aminobenzoate in the dog: neurotoxic or local anesthetic effect? |
| PubMed: | Effect of epidural and subarachnoid injections of a 10% butamben suspension. |
| PubMed: | Flocculation of suspensions containing nonionic surfactants by sorbitol. |
| PubMed: | Evaluation of anesthetic agents on human mucous membrane: an illustration of experimental protocol using computers. |
| PubMed: | [Clinical evaluation of new toothache drug "LTA"]. |
| PubMed: | Topical anesthetics: use and misuse. |
| PubMed: | [Clinical investigation of the action of lidocaine, procaine and butanylcaine]. |
| PubMed: | Methemoglobinemia induced by local anesthetics. |
| PubMed: | Controlled drug permeation. II. Comparative permeability and stability of butamben and benzocaine. |
| PubMed: | Controlled drug permeation I: controlled release of butamben through silicone membrane by complexation. |
| PubMed: | Specificity of eczematous hypersensitivity to p-aminobenzoic acid butyl ester (butesin). |
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