bromothymol blue
3,3'-dibromothymolsulfonphthalein
 
Notes:
a ph sensitive dye that has been used as an indicator in many laboratory reactions.
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Synonyms   Articles   Notes   Search
CAS Number: 76-59-5Picture of molecule3D/inchi
Other(deleted CASRN): 1007629-44-8
ECHA EINECS - REACH Pre-Reg: 200-971-2
FDA UNII: VGU4LM0H96
Nikkaji Web: J4.180G
Beilstein Number: 0373934
MDL: MFCD00005872
XlogP3-AA: 7.60 (est)
Molecular Weight: 624.38916000
Formula: C27 H28 Br2 O5 S
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: coloring agents (for surface only)
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 201.00 °C. @ 760.00 mm Hg
Boiling Point: 614.30 °C. @ 760.00 mm Hg (est)
Flash Point: 618.00 °F. TCC ( 325.30 °C. ) (est)
logP (o/w): 8.600 (est)
Soluble in:
 water, 8.825e-006 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: cosmetic colorants
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Suppliers:
BOC Sciences
For experimental / research use only.
Bromothymol Blue 95%
ECSA Chemicals
BROMOTHYMOL BLUE RPE-ACS-FOR ANALYSIS, G 25
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
EMD Millipore
For experimental / research use only.
Bromothymol Blue
Glentham Life Sciences
Bromothymol Blue
Santa Cruz Biotechnology
For experimental / research use only.
Bromothymol Blue
Sigma-Aldrich
For experimental / research use only.
Bromothymol Blue ACS reagent, Dye content 95 %
TCI AMERICA
For experimental / research use only.
Bromothymol Blue
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: coloring agents (for surface only)
Recommendation for bromothymol blue usage levels up to:
 not for fragrance use.
 
Recommendation for bromothymol blue flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 76-59-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6450
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2-bromo-4-[3-(3-bromo-4-hydroxy-2-methyl-5-propan-2-ylphenyl)-1,1-dioxo-2,1?6-benzoxathiol-3-yl]-3-methyl-6-propan-2-ylphenol
Chemidplus: 0000076595
RTECS: SJ7450000 for cas# 76-59-5
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References:
 2-bromo-4-[3-(3-bromo-4-hydroxy-2-methyl-5-propan-2-ylphenyl)-1,1-dioxo-2,1?6-benzoxathiol-3-yl]-3-methyl-6-propan-2-ylphenol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 76-59-5
Pubchem (cid): 6450
Pubchem (sid): 134971827
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 3204.19.4000
FDA Color Additive Status ListView
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 cosmetic colorants 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-bromo-3-methyl-6-(1-met- hylethyl)phenol) S,S-dioxide
4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis[2-bromo-3-methyl-6-(1-methylethyl)phenol] S,S-dioxide
2-bromo-4-[3-(3-bromo-4-hydroxy-2-methyl-5-propan-2-ylphenyl)-1,1-dioxo-2,1?6-benzoxathiol-3-yl]-3-methyl-6-propan-2-ylphenol
2-bromo-4-[3-(3-bromo-4-hydroxy-2-methyl-5-propan-2-ylphenyl)-1,1-dioxobenzo[c]oxathiol-3-yl]-3-methyl-6-propan-2-ylphenol
2-bromo-4-[3-(3-bromo-4-hydroxy-5-isopropyl-2-methylphenyl)-1,1-dioxido-3H-2,1-benzoxathiol-3-yl]-6-isopropyl-3-methylphenol
3,3-bis[3-bromo-4-hydroxy-2-methyl-5-(methylethyl)phenyl]benzo[c]1,2-oxathiolene-1,1-dione
a,a-bis(6-bromo-5-hydroxycarvacryl)-a-hydroxy-o-toluenesulfonic acid g-sultone
 bromothymol blue sulfone form
 bromthymol blue
3',3"-dibromothymolsolfonphthalein
 dibromothymolsulfonphthalein
3,3'-dibromothymolsulfonphthalein
3',3''-dibromothymolsulfonphthalein
 dibromothymolsulfophthalein
4,4'-(1,1-dioxido-3H-2,1-benzoxathiole-3,3-diyl)bis(2-bromo-6-isopropyl-3-methylphenol)
4,4'-(1,1-dioxido-3H-2,1-benzoxathiole-3,3-diyl)bis[2-bromo-3-methyl-6-(propan-2-yl)phenol]
 phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis(2-bromo-3-methyl-6-(1-methylethyl)-
 phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[2-bromo-3-methyl-6-(1-methylethyl)-
 phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-bromo-3-methyl-6-(1-methylethyl)-, S,S-dioxide
 phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis(2-bromo-3-methyl-6-(1-methylethyl))-, S,S-dioxide
 phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis[2-bromo-3-methyl-6-(1-methylethyl)-, S,S-dioxide
 phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis*2-bromo-3-methyl-6-(1-methylethyl)-, S,S-dioxide
 thymol, 6,6'-(3H-2,1-benzoxathiol-3-ylidene)bis[2-bromo-, S,S-dioxide
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Articles:
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PubMed: High performance optical absorbance detectors based on low noise switched integrators.
PubMed: [Cryptococcus neoformans chemotyping. Review of the literature. New epidemiologic data on cryptococcosis. Our experience with the use of C.G.B. media in the study of this yeast].
PubMed: [Effectiveness of the use of nutrient media in isolation of Yersinia].
PubMed: Investigation of relative humidity effects on the response behavior of a pH indicator-based OWG vapor sensor.
PubMed: A method for the estimation of traces of chlorhexidine in water.
PubMed: An optical waveguide acid vapor sensor.
PubMed: [Ethylene oxide sterilization. II. Influence of test devices on the performance of biological monitors and its evaluation].
PubMed: Flow injection and solvent extraction with intelligent segment separation. Determination of quaternary ammonium ions by ion-pairing.
PubMed: Tracking of proton flow during transition from anaerobiosis to steady state. 2. Effect of cation uptake on the response of a hydrophobic membrane bound pH indicator.
PubMed: Studies on the carboxymethyl chitosan-containing liposomes for their stability and controlled release of dapsone.
PubMed: [A method of quantitative analysis of gentamicin sulfate].
PubMed: Liquid-liquid distribution of ion-associates of acidic dyes with quaternary ammonium counter-ions.
PubMed: Characterization of Tn5-Induced Mutants of Xenorhabdus nematophilus ATCC 19061.
PubMed: [Identification of varieties of Cryptococcus neoformans by the use of culture media].
PubMed: Indicator characteristics of bromothymol blue derivatives.
PubMed: [Comparison of 2 field methods for urinary assay of chloroquine].
PubMed: Effect of surfactants on the stability of modified egg-yolk phosphatidyl choline liposomes.
PubMed: Relative merits of various rapid biopsy urease tests for diagnosis of Helicobacter pylori (Campylobacter pylori).
PubMed: Improved fluorogenic assay for rapid detection of Vibrio parahaemolyticus in foods.
PubMed: Comparative evaluation on mouse nasal immunogenicity of arylmethane-, xanthene-, quinone-imine-, and acridine-dye-inactivated Sendai virus vaccines.
PubMed: [Optimization of bacteriologic studies of cholera].
PubMed: Penicillinase-based enzyme-linked immunosorbent assay for the detection of plant viruses.
PubMed: The use of arginine brilliantgreen glucose peptone broth (ABGP medium) as a primary culture medium for Pseudomonas aeruginosa.
PubMed: Determination of quaternary ammonium surfactants in pharmaceutical formulations by the hypochromic effect.
PubMed: Sensitive high-performance liquid chromatographic assay for determination of amiloride in biologic fluids using an ion-pair extraction method.
PubMed: The mechanism of liposomal damage by taurocholate.
PubMed: Ethanolic bromothymol blue gives molar L/S ratios.
PubMed: Incompatibility of indometacin and benzalkonium in eye drops due to ion-pair formation.
PubMed: Biochemical serogrouping of clinical isolates of Cryptococcus neoformans.
PubMed: A rapid quantitative capillary tube enzyme immunoassay for human chorionic gonadotropin in urine.
PubMed: [Ion pairs of benzodiazepines and alkaloids with bromothymol blue and their analytical applications].
PubMed: Anesthetic-protein interaction: surface potential of bovine serum albumin estimated by a pH-sensitive dye.
PubMed: An evaluation of the use of a pH indicator for the detection of beta-lactamase in enzyme immunoassay.
PubMed: Automated flow-injection pseudotitration of boric acid.
PubMed: Automated flow-injection pseudotitration of strong and weak acids, ascorbic acid and calcium, and catalytic pseudotitrations of aminopolycarboxylic acids by use of a microcomputer-controlled analyser.
PubMed: Detection of bovine mastitis by bromothymol blue pH indicator test.
PubMed: An extractive spectrophotometric method for the determination of tetramisole hydrochloride in pharmaceutical preparations.
PubMed: [Rapid method for determining the drug resistance of gram-negative bacteria].
PubMed: Studies on the toxin of Aspergillus fumigatus. XVIII. Photooxidation of asp-hemolysin in the presence of various dyes and its relation to the site of hemolytic activity.
PubMed: [Use of bromthymol blue for studying the thermotropic properties of the liposomes from egg lecithin].
PubMed: Effect of gaseous conditions on isolation and growth of Ureaplasma urealyticum on agar.
PubMed: Prevalence of maltose-negative Neisseria meningitidis variants during an epidemic period in Spain.
PubMed: [The dynamics of the drug release from ointment bases. Part 5: The effects of tensides on the liberation of atropine from eye ointments (author's transl)].
PubMed: Dye-containing buffered charcoal-yeast extract medium for differentiation of members of the family Legionellaceae.
PubMed: Analytical utility of 2-halopyridinium salts-II Acidimetric determination of thiol groups.
PubMed: Simple disk technique for carbohydrate fermentation and esculin hydrolysis testing of anaerobic gram-negative bacilli.
PubMed: Hydrophilic region of lecithin membranes studied by bromothymol blue and effects of an inhalation anesthetic, enflurane.
PubMed: Modified metabolic inhibition test for serotyping strains of Ureaplasma urealyticum (T-strain Mycoplasma).
PubMed: Rapid pH and deltamuH+ jump by short laser pulse.
PubMed: Anion/calcium ion ratios and proton production in some mitochondrial calcium ion uptakes.
PubMed: Interaction of phenolsulphonphthalein dyes with rabbit plasma and rabbit serum albumin.
PubMed: About some common biochemical and pharmacological properties of bile salts and non steroidal anti-inflammatory drugs.
PubMed: Liposomal membrane. I. Chemical damage of liposomal membranes with functional detergent.
PubMed: Renal handling of phenol red. III. Bidirectional transport.
PubMed: Bromothymol blue broth: improved medium for detection of Ureaplasma urealyticum (T-strain mycoplasma).
PubMed: Uptake and inactivation of prostaglandin E2 methyl analogues in the rat pulmonary circulation.
PubMed: Rapid microdilution-colorimetric assay for yeast susceptibility to fluorocytosine.
PubMed: Light-induced pH changes and changes in absorbance of pH indicators in Rhodospirillum rubrum chromatophores.
PubMed: Bromothymol blue and carbohydrate-sensitive plating media.
PubMed: Modified Sutter's arginine dihydrolase medium for Pseudomonas speciation.
PubMed: Chemically defined antimicrobial susceptibility test medium for Pseudomonas aeruginosa.
PubMed: Inositol as a selective substrate for the growth of Klebsiellae and Serratiae.
PubMed: Ion-pair extraction method for quantitation of a bisquaternary ammonium compound, pancuronium bromide.
PubMed: A kinetic study of protein-protein interactions.
PubMed: Renal handling of phenol red. II. The mechanism of substituted phenolsulphophthalein (PSP) dye transport in rabbit kidney tubules in vitro.
PubMed: Quantitative determination of piperazine citrate in piperazine citrate syrup USP.
PubMed: Effect of phase transition on the kinetics of dye transport in phospholipid bilater structures.
PubMed: Possible mechanisms of the efflux of glutamate from kidney mitochondria generated by the activity of mitochondrial glutaminase.
PubMed: Regulatory effects of fatty acyl-coenzyme A derivatives on phosphate-activated pig brain and kidney glutaminase in vitro.
PubMed: Determination of methadone hydrochloride in a maintenance dosage formulation.
PubMed: The inhibition by bromothymol blue of anion translocation across the mitochondrial membrane.
PubMed: Interactions between nonsteroidal anti-inflammatory drugs and biological membranes-III. Effect of nonsteroidal anti-inflammatory drugs on bound mitochondrial bromothymol blue and possible intramitochondrial pH variations induced by these drugs.
PubMed: A strctural comparison of ligand-saturated hemoglobin with protoporphyrin globin. I. Reaction with bromothymol blue and sulfhydryl reagents.
PubMed: Inhibition of succinate oxidation in mitochondria by bromothymol blue.
PubMed: An improved urease-bromothymol blue agar medium for detection of wheat grains contaminated with urine.
PubMed: A survey on the occurrence of Vibrio parahaemolyticus on fish and shellfish, marketed in the Netherlands.
PubMed: The energy-linked nature of respiration-dependent bromothymol blue color decrease in submitochondrial particles.
PubMed: Bromothymol blue and bromocresol purple as indicators of pH changes in chromatophores of Rhodospirillum rubrum.
PubMed: Determination of first pKa' value and partition coefficients of bromothymol blue.
PubMed: Hydrogen ion concentration of tear fluid. Estimated on the basis of a bromothymol-blue-dyed lacrimal streak.
PubMed: Bromothymol blue. Vital staining of conjunctiva and cornea.
PubMed: Light-induced interactions of Rhodospirillum rubrum chromatophores with bromothymol blue.
PubMed: PHOTOMETRIC DETERMINATION OF AMINES AND QUATERNARY AMMONUIM COMPOUNDS WITH BROMOTHYMOL BLUE.
PubMed: PHOTOMETRIC DETERMINATION OF AMINES AND QUATERNARY AMMONUIM COMPOUNDS WITH BROMOTHYMOL BLUE. 6. ASSOCIATION IN AQUEOUS SOLUTION BETWEEN BROMOTHYMOL BLUE AND QUATERNARY AMMONIUM IONS.
PubMed: PHOTOMETRIC DETERMINATION OF AMINES AND QUATERNARY AMMONIUM COMPOUNDS WITH BROMOTHYMOL BLUE. 4. EXTRACTION CONSTANTS AND CALCULATION OF EXTRACTION CONDITIONS.
PubMed: PHOTOMETRIC DETERMINATION OF AMINES AND QUATERNARY AMMONIUM COMPOUNDS WITH BROMOTHYMOL BLUE. 3. PARTITION OF BROMOTHYMOL BLUE BETWEEN WATER AND METHYLENE CHLORIDE.
PubMed: Photometric determination of amines and quaternary ammonium compounds with bromothymol blue. I.
PubMed: Bromothymol blue screening test; value for determination of blood cholinesterase activity.
PubMed: [Bromothymol blue in colorimetric determination of certain quaternary ammonium compounds and amines].
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