bis(tributyl tin) oxide
6-oxa-5,7-distannaundecane, 5,5,7,7-tetrabutyl-
 
Notes:
None found
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CAS Number: 56-35-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 200-268-0
FDA UNII: 3353Q84MKM
Beilstein Number: 745057
MDL: MFCD00009418
Molecular Weight: 596.11358000
Formula: C24 H54 O Sn2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: indirect food additives: adhesives and components of coatings
 
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FDA Mainterm (IAUFC):56-35-9 ; BIS(TRI-N-BUTYLTIN) OXIDE
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
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Physical Properties:
Appearance: pale yellow clear liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.17000 @  25.00 °C.
Refractive Index: 1.48600 @  20.00 °C.
Melting Point: -45.00 °C. @ 760.00 mm Hg
Boiling Point: 474.00 to  475.00 °C. @ 760.00 mm Hg (est)
Flash Point: > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 3.840 (est)
Soluble in:
 water, 19.5 mg/L @ 25 °C (exp)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Santa Cruz Biotechnology
For experimental / research use only.
bis(Tributyltin) Oxide ≥96%
Sigma-Aldrich: Aldrich
For experimental / research use only.
bis(tributyltin) oxide 96%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  12500 ug/kg
Russian Pharmacology and Toxicology Vol. 42, Pg. 73, 1979.

intravenous-mouse LD50  6 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 31, 1976.

oral-mouse LD50  55 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(5), Pg. 10, 1976.

oral-rabbit LDLo  50 mg/kg
Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 15, Pg. 3, 1973.

intraperitoneal-rat LD50  5 mg/kg
BEHAVIORAL: COMA GASTROINTESTINAL: ALTERATION IN GASTRIC SECRETION
National Technical Information Service. Vol. OTS0571270

oral-rat LD50  87 mg/kg
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1255, 1986.

Dermal Toxicity:
skin-mouse LD50 163 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) KIDNEY, URETER, AND BLADDER: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

skin-rabbit LD50 900 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 31, 1976.

skin-rat LD50 > 300 mg/kg
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
National Technical Information Service. Vol. OTS0571915

Inhalation Toxicity:
inhalation-guinea pig LCLo 200 mg/m3
BEHAVIORAL: AGGRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA
European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 339, 1976.

inhalation-rat LC50 64 uL/m3/4H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
National Technical Information Service. Vol. OTS0572027

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Safety in Use Information:
Category: indirect food additives: adhesives and components of coatings
Recommendation for bis(tributyl tin) oxide usage levels up to:
 not for fragrance use.
 
Recommendation for bis(tributyl tin) oxide flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf
EPI System: View
EPA-Iris: IRIS
NIOSH International Chemical Safety Cards: search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 56-35-9
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 16682746
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 tributyl(tributylstannyloxy)stannane
Chemidplus: 0000056359
EPA/NOAA CAMEO: hazardous materials
RTECS: 56-35-9
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References:
 tributyl(tributylstannyloxy)stannane
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 56-35-9
Pubchem (cid): 16682746
Pubchem (sid): 134972605
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C18149
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2931.00.5029
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
usepaopp pesticide code 083001; trade names: self polishing copolymer, tbto, biomet, biomet 75, aw 75-d, butinox, bio-met tbto, bis(tri-n-butyltin)oxide, bto, sn-9, ent 24,979, l.s. 3394.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
6-oxa-5,7-distannaundecane, 5,5,7,7-tetrabutyl-
 distannoxane, 1,1,1,3,3,3-hexabutyl-
 hexabutyl distannoxane
 hexabutyldistannoxane
 tri-N-butyltin oxide
bis(tri-N-butyltin) oxide
bis(tri-N-butyltin)oxide
bis(tributyl tin)oxide
 tributyl(tributylstannyloxy)stannane
bis(tributylstannyl)oxide
 tributyltin oxide
 tributyltin(IV) oxide
bis(tributyltin) oxide
bis(tributyltin)oxide
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Articles:
PubMed: Synthesis of thiophene 1,1-dioxides and tuning their optoelectronic properties.
PubMed: Assessment of antifouling biocides contaminations in Maizuru Bay, Japan.
PubMed: Oxygen consumption by Daphnia magna Straus as a marker of chemical stress in the aquatic environment.
PubMed: Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats.
PubMed: [Soil sorption of bis-(tributylin) oxide].
PubMed: Toxicity of tributyltin and triphenyltin to early life-stages of Paracentrotus lividus (Echinodermata: Echinoidea).
PubMed: Synthesis of oxidized methyl 4-O-methyl-beta-D-glucopyranoside and methyl beta-D-glucopyranosyl-(1-->4)-beta-D-glucopyranoside derivatives as substrates for fluorescence labeling reactions.
PubMed: Effects of bis(tributyltin)oxide on antipredator behavior in threespine stickleback Gasterosteus aculeatus L.
PubMed: Experiences on persistent organic pollutants under the Law concerning the Examination and Regulation of Manufacture, etc. of Chemical Substances, Japan, with references to biodegradation and bioaccumulation.
PubMed: Polymeric[mu(3)-(N-phosphonomethyl)-glycinato]tris(tri-n-butyltin).
PubMed: Sweat gland toxicity induced by bis (tributyltin) oxide: an ultrastructural and X-ray microanalysis study.
PubMed: Determination of bis(tributyltin) oxide by GC--MS with on-line hydride derivatization: application to drug substance analysis.
PubMed: Life-cycle toxicity of bis(tributyltin) oxide to the sheepshead minnow (Cyprinodon variegatus).
PubMed: [Health and environmental risk assessment of organotin pollution in Japan].
PubMed: Comparison of tributyltin compound effects on the alga Scenedesmus quadricauda and the benthic organisms Tubifex tubifex and Chironomus plumosus.
PubMed: Bis(tributyltin) oxide toxicology.
PubMed: Tributyltin use in interior paints: a continuing health hazard.
PubMed: Toxic effects of bis (tributyltin) oxide on the synthesis and secretion of zymogen granules in the rat exocrine pancreas.
PubMed: Synthetic studies of erythromycin derivatives. Synthesis and antimicrobial activities of 3''-EPI-erythromycin A and (9S)-11-dehydroxy-9-deoxo-9-hydroxy-11- oxoerythromycin A.
PubMed: Inhibition of mouse spleen cell activity by organotin compounds: effect of attachment of a maltose residue to the organotin group.
PubMed: The toxic effects of bis (tributyltin) oxide on the rat thoracic aorta.
PubMed: Studies on the hepatotoxicity induced by bis (tributyltin) oxide.
PubMed: The role of the rat submandibular gland in the excretion of bis (tributyltin) oxide: electron microscopy, X-ray microanalysis and atomic absorption analysis.
PubMed: Acute effect of indoor exposure to paint containing bis(tributyltin) oxide--Wisconsin, 1991.
PubMed: Corneal edema induced by bis (tributyltin) oxide.
PubMed: Accumulation of bis(tributyltin) oxide by the marine mussel Mytilus edulis.
PubMed: Coincident plasmids and antimicrobial resistance in marine bacteria isolated from polluted and unpolluted Atlantic Ocean samples.
PubMed: Bacteriostatic and bactericidal modes of action of bis(tributyltin)oxide on Legionella pneumophila.
PubMed: Dibutyltin oxide--phenyl isocyanate system for regioselective phenylcarbamoylation of the hydroxy-groups of ribonucleosides.
PubMed: [Influence of a tributyltin oxide oily aerosol on the exploratory behaviour toward the mouse (author's transl)].
PubMed: Regioselective phenylcarbamoylation of hydroxy-groups of ribonucleosides with bis(tributyltin) oxide--phenyl isocyanate system.
PubMed: [Effects in the guinea pig of an aerosol with a tributylitin oxide base].
PubMed: Determination of bis(tributyltin)oxide in air by atomic absorption spectroscopy or pyrolysis gas chromatography.
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