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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 232.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 568.23 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 567.00 °F. TCC ( 297.50 °C. ) (est)
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| logP (o/w): | 1.940 |
| Soluble in: |
| | water, 75.14 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 > 4500 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for betamethasone usage levels up to: | | | not for fragrance use.
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| Recommendation for betamethasone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Report for 2014 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products View page or View pdf |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 9782 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| | (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| Chemidplus: | 0000378449 |
| RTECS: | TU4000000 for cas# 378-44-9 |
References:
| | (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 9782 |
| Pubchem (sid): | 134975144 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C06848 |
| HMDB (The Human Metabolome Database): | HMDB14586 |
| Export Tariff Code: | 2903.99.8001 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations: •available commercially as the alcohol and as the 17-valerate, 17-benzoate, 17,21-dipropionate, disodium 21-phosphate salt.
•beta-corlan, becort, betasolon, betnelan, celestene, celestone, dermabet, diprolene, visubeta
•celestovet betamethasone acetate
•bebate, beben, benisone, euvaderm, flurobate, parbetan, uticort betamethasone benzoate
•diproderm, diprophos, diprosis, diprosone, maxivate, rinderon-dp betamethasone dipropioniate
•bedremin, betnesol-v, betneval, betnovate, bextasol, celestan-v, celestoderm-v, dermosol, dermovaleas, ecoval 70, hormezon, tokuderm, valisone betamethasone valerate
•bentelan, betnesol, celestan, durabetason, vista-methasone betamethasone phosphate disodium salt
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | betaderm | | | betametasone | | | betamethasonum | | | betatrex | | | celestone | | b- | corlan | | | dermabet | | | diprolene | | (8S,9R,10S,11S,13S,14S,16S,17R)-9- | fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one | | (11b,16b)-9- | fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione | | | lotrisone | | b- | methasone | | b- | methasone alcohol | | | pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11b,16b)- |
Articles:
| PubMed: | Monitoring of 35 illegally added steroid compounds in foods and dietary supplements. |
| PubMed: | Olanzapine and Betamethasone Are Effective for the Treatment of Nausea and Vomiting due to Metastatic Brain Tumors of Rectal Cancer. |
| PubMed: | Validation of a liquid chromatography method for the simultaneous determination of several nonsteroidal anti-inflammatory drugs in human plasma for therapeutic drug monitoring. |
| PubMed: | Fast and multiresidue determination of twenty glucocorticoids in bovine milk using ultra high performance liquid chromatography-tandem mass spectrometry. |
| PubMed: | Validation of a recombinant cell bioassay for the detection of (gluco)corticosteroids in feed. |
| PubMed: | Simultaneous determination of eight corticosteroids in bovine tissues using liquid chromatography-tandem mass spectrometry. |
| PubMed: | Detection and quantitative analysis of 21 veterinary drugs in river water using high-pressure liquid chromatography coupled to tandem mass spectrometry. |
| PubMed: | Prescription drug use in pregnancy: a retrospective, population-based study in British Columbia, Canada (2001-2006). |
| PubMed: | [Detection of glucocorticoids by pressurized capillary electrochromatography with ultra-violet detection and its application in hair analysis]. |
| PubMed: | Validation of a multi-residue enzyme-linked immunosorbent assay for qualitative screening of corticosteroids in liver, urine and milk. |
| PubMed: | Recombinant cell bioassays for the detection of (gluco)corticosteroids and endocrine-disrupting potencies of several environmental PCB contaminants. |
| PubMed: | Development of a liquid chromatography-tandem mass spectrometry with pressurized liquid extraction for determination of glucocorticoid residues in edible tissues. |
| PubMed: | Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of glucocorticoid residues in edible tissues of swine, cattle, sheep, and chicken. |
| PubMed: | Cluster headache. |
| PubMed: | Seborrhoeic dermatitis. |
| PubMed: | Allergy-induced preterm labor after the ingestion of shellfish. |
| PubMed: | Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study. |
| PubMed: | The prolonged effect of repeated maternal glucocorticoid exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species. |
| PubMed: | Optimization of solid phase extraction clean up and validation of quantitative determination of corticosteroids in urine by liquid chromatography-tandem mass spectrometry. |
| PubMed: | Hypersensitivity reaction to the ingestion of mango flesh. |
| PubMed: | Cluster headache. |
| PubMed: | Rapid multi-residue method for the quantitative determination and confirmation of glucocorticosteroids in bovine milk using liquid chromatography-electrospray ionization-tandem mass spectrometry. |
| PubMed: | Multi-detection of corticosteroids in sports doping and veterinary control using high-resolution liquid chromatography/time-of-flight mass spectrometry. |
| PubMed: | Seborrhoeic dermatitis. |
| PubMed: | Detection of synthetic corticosteroids in bovine urine by chemiluminescence high-performance liquid chromatography. |
| PubMed: | Pediatric drug labeling: improving the safety and efficacy of pediatric therapies. |
| PubMed: | Effect of betamethasone on maternal glucose. |
| PubMed: | Betamethasone valerate foam for treatment of nonscalp psoriasis. |
| PubMed: | Clotrimazole/betamethasone diproprionate: a review of costs and complications in the treatment of common cutaneous fungal infections. |
| PubMed: | Differentiation between dexamethasone and betamethasone in a mixture using multiple mass spectrometry. |
| PubMed: | Simultaneous determination of betamethasone and dexamethasone residues in bovine liver by liquid chromatography/tandem mass spectrometry. |
| PubMed: | Chemiluminescence detection of nine corticosteroids in liver. |
| PubMed: | Suppression of food intake is linked to enteric inflammation in nematode-infected rats. |
| PubMed: | Effects of Kakkon-to and Sairei-to on experimental elevation of aqueous flare in pigmented rabbits. |
| PubMed: | Evaluation of the test system used for in vitro release of drugs for topical dermatological drug products. |
| PubMed: | Assessment of pain during locomotion and the welfare of adult male turkeys with destructive cartilege loss of the hip joint. |
| PubMed: | Local anti-inflammatory activity and systemic side effects of NM-135, a new prodrug glucocorticoid, in an experimental inflammatory rat model. |
| PubMed: | Identification of main corticosteroids as illegal feed additives in milk replacers by liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry. |
| PubMed: | Factors associated with growth of extremely premature infants during initial hospitalization. |
| PubMed: | Evaluation of the proposed FDA pilot dose-response methodology for topical corticosteroid bioequivalence testing. |
| PubMed: | Assessment of the welfare of food restricted male broiler breeder poultry with musculoskeletal disease. |
| PubMed: | Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. |
| PubMed: | Topical corticosteroids: quality control considerations. |
| PubMed: | Relationship between in vivo skin blanching and in vitro release rate for betamethasone valerate creams. |
| PubMed: | [A case of asthma exacerbated by sulfite contained in betamethasone]. |
| PubMed: | [Iatrogenic Cushing syndrome in infants. Report of a case with dwarfism]. |
| PubMed: | Stability of betamethasone sodium phosphate, hydrocortisone sodium phosphate, and prednisolone sodium phosphate injections submitted by U.S. hospitals. |
| PubMed: | Stability of sterile aqueous epinephrine injections submitted by U.S. hospitals. |
| PubMed: | Stability of sterile aqueous lidocaine hydrochloride and epinephrine injections submitted by U.S. hospitals. |
| PubMed: | The inhibitory effect of ketotifen on in vitro histamine release in allergic patients. |
| PubMed: | [Studies of toxicity of hydrocortisone 17-butyrate 21-propionate -5. Chronic toxicity in rats by percutaneous administration (author's transl)]. |
| PubMed: | Drugs released for clinical use. |
| PubMed: | Corticosteroids in diseases of the oral mucosa. |
| PubMed: | [Periocically occurring aphthae]. |
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