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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 460.94 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 420.00 °F. TCC ( 215.80 °C. ) (est)
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| logP (o/w): | 5.003 (est) |
| Soluble in: |
| | water, 1.772 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-mouse LD50 180 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03239
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for beta-naphthoflavone usage levels up to: | | | not for fragrance use.
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| Recommendation for beta-naphthoflavone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 5,6- | benzoflavone | | 1H- | naphtho(2,1-b)pyran-1-one, 3-phenyl- | | 1H- | naphtho[2, 1-b]pyran-1-one, 3-phenyl- | | b- | naphthoflavone | | 3- | phenyl-1H-benzo[f]chromen-1-one | | 3- | phenyl-1H-naphtho(2,1-b)pyran-1-one | | 3- | phenyl-1H-naphtho[2, 1-b]pyran-1-one | | 3- | phenyl-1H-naphtho[2,1-b]pyran-1-one | | 3- | phenyl-benzo[f]chromen-1-one | | 3- | phenylbenzo[f]chromen-1-one |
Articles:
| PubMed: | Effect of dihydromyricetin on benzo[a]pyrene activation in rats. |
| PubMed: | Embryonic exposure of medaka (Oryzias latipes) to propylparaben: effects on early development and post-hatching growth. |
| PubMed: | Non-dioxin-like AhR ligands in a mouse peanut allergy model. |
| PubMed: | Impact of beta-naphthoflavone on genotoxicity of food-derived carcinogens. |
| PubMed: | Dynamics of BNF-induced in vivo ethoxyresorufin-O-deethylase (EROD) activity during embryonic development of medaka (Oryzias latipes). |
| PubMed: | Potent modification of inducible CYP1A1 expression by flavonoids. |
| PubMed: | Recombinant aryl hydrocarbon receptors for bioassay of aryl hydrocarbon receptor ligands in transgenic tobacco plants. |
| PubMed: | Induction of cytochromes P450 in small intestine by chemopreventive compounds. |
| PubMed: | Energy intake affects the biotransformation rate, scope for induction, and metabolite profile of benzo[a]pyrene in rainbow trout. |
| PubMed: | Inhibitory effects of a dietary phytochemical 3,3'-diindolylmethane on the phenobarbital-induced hepatic CYP mRNA expression and CYP-catalyzed reactions in female rats. |
| PubMed: | A noninvasive test of exposition to toxicants: quantitative analysis of cytochrome P4501A expression in fish scales. |
| PubMed: | Inducibility of UDP-glucuronosyltransferase 1As by beta-naphthoflavone in HepG2 cells. |
| PubMed: | Resveratrol affects CYP1A expression in rainbow trout hepatocytes. |
| PubMed: | The impact of glucuronidation on the bioactivation and DNA adduction of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in vivo. |
| PubMed: | 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells. |
| PubMed: | Blarina brevicauda as a biological monitor of polychlorinated biphenyls: evaluation of hepatic cytochrome P450 induction. |
| PubMed: | Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites. |
| PubMed: | Effects of lactic acid bacteria on the uptake and distribution of the food mutagen Trp-P-2 in mice. |
| PubMed: | Intestinal responses to xenobiotics. |
| PubMed: | Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine. |
| PubMed: | [In vitro study of the interference of certain food components with the metabolism of aflatoxin B1]. |
| PubMed: | [In vivo studies of the inhbitory effect of various food components on aflatoxin B1 metabolism]. |
| PubMed: | Differential response of cultured human umbilical vein and artery endothelial cells to Ah receptor agonist treatment: CYP-dependent activation of food and environmental mutagens. |
| PubMed: | DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in fetal tissues of patas monkeys after transplacental exposure. |
| PubMed: | Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat. |
| PubMed: | Biotransformation and clearance of 3-(phenylamino)propane-1,2-diol, a compound present in samples related to toxic oil syndrome, in C57BL/6 and A/J mice. |
| PubMed: | An expressional system of human cytochrome P-450 CYP1A1 gene transcription. |
| PubMed: | In vitro inhibition of thyroid hormone sulfation by hydroxylated metabolites of halogenated aromatic hydrocarbons. |
| PubMed: | Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines. |
| PubMed: | Induction of ethoxyresorufin O-deethylase (EROD) and endothelial activation of the heterocyclic amine Trp-P-1 in bird embryo hearts. |
| PubMed: | Inhibition of mouse and human CYP 1A- and 2E1-dependent substrate metabolism by the isoflavonoids genistein and equol. |
| PubMed: | Measuring the potency of pulp mill effluents for induction of hepatic mixed-function oxygenase activity in fish. |
| PubMed: | Major involvement of rabbit liver cytochrome P4501A in thiabendazole 5-hydroxylation. |
| PubMed: | Ahr locus phenotype in congenic mice influences hepatic and pulmonary DNA adduct levels of 2-amino-3-methylimidazo[4,5-f]quinoline in the absence of cytochrome P450 induction. |
| PubMed: | Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. |
| PubMed: | The model Ah-receptor agonist beta-naphthoflavone inhibits aflatoxin B1-DNA binding in vivo in rainbow trout at dietary levels that do not induce CYP1A enzymes. |
| PubMed: | Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1 hepatocarcinogenesis in rainbow trout. |
| PubMed: | DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder, and kidney of congenic mice differing in Ah responsiveness and N-acetyltransferase genotype. |
| PubMed: | Effects of enzyme induction on the distribution of the food carcinogen 2-amino-3,8-dimethyl-imidazo[4,5-ss]-quinoxaline (MeIQx) in Ah-receptor- responsive- and Ah-receptor-non-responsive mice. |
| PubMed: | Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: alpha-naphthoflavone, beta-naphthoflavone and trout CYP1A1 peptide antibody. |
| PubMed: | Regulation of hepatic cytochrome P4501A by indole-3-carbinol: transient induction with continuous feeding in rainbow trout. |
| PubMed: | Metabolic activation of the food mutagen 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]indole (Trp-P-1) in endothelial cells of cytochrome P-450-induced mice. |
| PubMed: | Indole-3-carbinol induces a rat liver glutathione transferase subunit (Yc2) with high activity toward aflatoxin B1 exo-epoxide. Association with reduced levels of hepatic aflatoxin-DNA adducts in vivo. |
| PubMed: | Indole-3-carbinol and beta-naphthoflavone induction of aflatoxin B1 metabolism and cytochromes P-450 associated with bioactivation and detoxication of aflatoxin B1 in the rat. |
| PubMed: | Metabolic activation of the food mutagen Trp-P-1 in endothelial cells of heart and kidney in cytochrome P450-induced mice. |
| PubMed: | Hepa-1 enzyme induction assay as an in vitro indicator of the CYP1A1-inducing potencies of laboratory rodent diets in vivo. |
| PubMed: | Effects of capsaicin on liver microsomal metabolism of the tobacco-specific nitrosamine NNK. |
| PubMed: | Cytochrome P450 induction and metabolism of alkoxyresorufins, ethylmorphine and testosterone in cultured hepatocytes from goats, sheep and cattle. |
| PubMed: | Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. |
| PubMed: | Cytochrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines. |
| PubMed: | Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse. |
| PubMed: | Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices. |
| PubMed: | Tissue distribution of the food mutagen MeIQx in control and BNF-treated mice. |
| PubMed: | Acute renal toxicity of thiabendazole (TBZ) in ICR mice. |
| PubMed: | [Mixed-function oxidase induction as a test for the biological monitoring of water: limitations and prospects]. |
| PubMed: | Covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein in microsomal incubations and isolated rat hepatocytes. |
| PubMed: | Effects of reserpine and L-cysteine and glutathione depletion on 2-bromoethylamine hydrobromide-induced tubular necrosis in Swiss ICR mice. |
| PubMed: | Chemoprotective and hepatic enzyme induction properties of indole and indenoindole antioxidants in rats. |
| PubMed: | Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine. |
| PubMed: | Effects of the food mutagens MeIQx and PhIP on the expression of cytochrome P450IA proteins in various tissues of male and female rats. |
| PubMed: | The contribution of N-oxidation to the metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat hepatocytes. |
| PubMed: | Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes. |
| PubMed: | Studies of cytotoxicity and metabolic competence with the rat intestinal cell line IEC-17. |
| PubMed: | Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation. |
| PubMed: | 4-(2-amino-1-methylimidazo[4,5-b]pyrid-6-yl)phenyl sulfate--a major metabolite of the food mutagen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) in the rat. |
| PubMed: | The metabolism of 4,8-DiMeIQx in conventional and germ-free rats. |
| PubMed: | Metaplastic pancreatic cells in liver tumors induced by diethylnitrosamine. |
| PubMed: | Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254. |
| PubMed: | Comparative effect of dietary butylated hydroxyanisole and beta-naphthoflavone on aflatoxin B1 metabolism, DNA adduct formation, and carcinogenesis in rainbow trout. |
| PubMed: | Specificity of rabbit cytochrome P-450 isozymes involved in the metabolic activation of the food derived mutagen 2-amino-3-methylimidazo[4,5-f] quinoline. |
| PubMed: | Epoxide-metabolizing enzymes in mammary gland and liver from BALB/c mice and effects of inducers on enzyme activity. |
| PubMed: | The significance of glutathione conjugation for aflatoxin B1 metabolism in rainbow trout and coho salmon. |
| PubMed: | Alterations in hepatic microsomal protein levels in rainbow trout fed cyclopropenoid fatty acids analyzed by two-dimensional gel electrophoresis. |
| PubMed: | A model system for studying covalent binding of food carcinogens MeIQx, MeIQ and IQ to DNA and protein. |
| PubMed: | B-naphthoflavone induction and its effect on hepatic phospholipid metabolism in rainbow trout (Salmo gairdneri). |
| PubMed: | Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. |
| PubMed: | In vitro metabolism of teratogens by differentiating rat embryo cells. |
| PubMed: | Mutagens in cooked foods--metabolism and genetic toxicity. |
| PubMed: | Identification and mutagenicity of aflatoxicol-M1 produced by metabolism of aflatoxin B1 and aflatoxicol by liver fractions from rainbow trout (Salmo gairdneri) fed beta-naphthoflavone. |
| PubMed: | Mutagenicity of structurally related aromatic amines in the Salmonella/mammalian microsome test with various S-9 fractions. |
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