Articles:
8-azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-, endo-, methanesulfonate
Notes:
a centrally active muscarinic antagonist that has been used in the symptomatic treatment of parkinson disease. benztropine also inhibits the uptake of dopamine.
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 132-17-2 Benztropine Mesylate >98% Benztropine inhibits MTSET-induced inhibition of [3H]WIN binding to Wild-type dopamine transporter with EC50 of 28 ?M in concentration-dependent manner.
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| CAS Number: | 132-17-2 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 205-048-8 | |
| FDA UNII: | WMJ8TL7510 | |
| MDL: | MFCD00074784 | |
| Molecular Weight: | 403.54193000 | |
| Formula: | C22 H29 N O4 S | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 143.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 409.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000001 mmHg @ 25.00 °C. (est) |
| Flash Point: | 248.00 °F. TCC ( 120.10 °C. ) (est) |
| logP (o/w): | 4.962 (est) |
| Soluble in: | |
| water, 1.068 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Benztropine Mesylate >98%
Odor: characteristic Use: Benztropine inhibits MTSET-induced inhibition of [3H]WIN binding to Wild-type dopamine transporter with EC50 of 28 ?M in concentration-dependent manner. |
| Carbosynth |
| For experimental / research use only. |
| Benztropine Mesylate |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Benztropine Mesylate ≥98% |
| Sarchem Laboratories |
| For experimental / research use only. |
| Benztropine Mesylate |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Benztropine Mesylate ≥98% (HPLC) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-cat LDLo 33 mg/kg Compilation of LD50 Values of New Drugs. oral-human TDLo 100 ug/kg BEHAVIORAL: TOXIC PSYCHOSIS Proceedings of the European Society for the Study of Drug Toxicity. Vol. 8, Pg. 59, 1967. intraperitoneal-mouse LD50 65 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 555, 1963. intravenous-mouse LD50 24 mg/kg "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972. oral-mouse LD50 91 mg/kg Drugs in Japan Vol. 6, Pg. 775, 1982. oral-rat LD50 940 mg/kg Drugs in Japan Vol. 6, Pg. 775, 1982. | |
| Dermal Toxicity: | |
|
subcutaneous-guinea pig LD50 80 mg/kg AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962. subcutaneous-mouse LD50 103 mg/kg "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972. subcutaneous-rat LD50 353 mg/kg "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 208, 1972. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for benztropine mesylate usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for benztropine mesylate flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 8584 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| (1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonicacid | |
| Chemidplus: | 0000132172 |
| RTECS: | YM3150000 for cas# 132-17-2 |
References:
| (1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonicacid | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 8584 |
| Pubchem (sid): | 134973916 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| KEGG (GenomeNet): | D00778 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2933.90.9500 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether methanesulfonate | |
| (1R,5R)-3- | benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane;methanesulfonicacid |
| benzotropine methanesulfonate | |
| benzotropinemesylate | |
| benztropine mesilate | |
| benztropine methanesulfonate | |
| 8-aza | bicyclo(3.2.1)octane, 3-(diphenylmethoxy)-, endo-, methanesulfonate |
| 8-aza | bicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-, methanesulfonate (9CI) |
| cobrentin methanesulfonate | |
| cogentin | |
| cogentin methanesulfonate | |
| 3- | diphenyl methoxytropane methanesulfonate |
| endo-3-( | diphenylmethoxy)-8-methyl-8-azoniabicyclo(3.2.1)octane methanesulphonate |
| 3- | diphenylmethoxytropane mesylate |
| 3- | diphenylmethoxytropane methanesulfonate |
| lopac-B-8262 | |
| N- | methylbenztropine |
| tropine benzohydryl ether methanesulfonate |