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Category: buffering agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white to tan powder (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 151.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 409.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 2.320000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 420.00 °F. TCC ( 215.30 °C. ) (est)
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| logP (o/w): | 2.300 |
| Soluble in: |
| | water, 1410 mg/L @ 25 °C (exp) | | | water, 2714 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Trospium Impurity A
Odor: characteristic Use: Benzilic Acid is an impurity of Trospium. Trospium is a derivative of tropine with anticholinergic property, which is used in the treatment of urinary incontinence as an antispasmodic. |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| Benzilic Acid ≥99%
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Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 2000 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 116, Pg. 154, 1958.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 1300 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 116, Pg. 154, 1958.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | buffering agents |
| Recommendation for benzilic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for benzilic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzeneacetic acid, a-hydroxy-a-phenyl- | | | benzilicacid | | | benzylic acid | | 2,2- | diphenyl-2-hydroxyacetic acid | | a,a- | diphenyl-a-hydroxyacetic acid | | | diphenylglycolic Acid | | a,a- | diphenylglycolic acid | | | diphenylhydroxyacetic acid | | | glycolic acid, diphenyl- | | 2- | hydroxy-2,2-diphenylacetic acid | | a- | hydroxy-2,2-diphenylacetic acid | | 2- | hydroxy-2,2-diphenylaceticacid | | a- | hydroxy-a-phenylbenzeneacetic acid | | | hydroxy(diphenyl)acetic acid | | | hydroxydiphenylacetic acid | | a- | hydroxydiphenylacetic acid | | a- | phenylmandelic acid |
Articles:
| PubMed: | Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities. |
| PubMed: | Transition-metal-free and chemoselective NaO(t)Bu-O2-mediated oxidative cleavage reactions of vic-1,2-diols to carboxylic acids and mechanistic insight into the reaction pathways. |
| PubMed: | A computational study of base-catalyzed reactions of cyclic 1,2-diones: cyclobutane-1,2-dione. |
| PubMed: | A mechanistic study on the Hooker oxidation: synthesis of novel indane carboxylic acid derivatives from lapachol. |
| PubMed: | WYE-120318, a ring contraction product of methylnaltrexone, and structure revision of coniothyrione. |
| PubMed: | B-norsteroids from Hymenoscyphus pseudoalbidus. |
| PubMed: | Oxidative decarboxylation of benzilic acid by a biomimetic iron(II) complex: evidence for an iron(IV)-oxo-hydroxo oxidant from O2. |
| PubMed: | Domino reactions consisting of heterocyclization and 1,2-migration-redox-neutral and oxidative transition-metal catalysis. |
| PubMed: | Thermally assisted methylation and subsequent silylation of scheduled acids of chemical weapon convention for on-site analysis and its comparison with the other methods of methylation. |
| PubMed: | Synthesis and antimicrobial evaluation of new 3-alkyl/aryl-2-[((alpha,alpha-diphenyl-alpha-hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinones. |
| PubMed: | Preparation, circular dichroism induced helical conformation and optical property of chitosan acid salt complexes for biomedical applications. |
| PubMed: | Total synthesis of meloscine by a [2+2]-photocycloaddition/ring-expansion route. |
| PubMed: | Regioselective glycosylation of 7-azapteridines and conversion of the 7-azapteridine nucleosides into 6-azapurine nucleosides. |
| PubMed: | Identification of fredericamycin E from Streptomyces griseus: Insights into fredericamycin A biosynthesis highlighting carbaspirocycle formation. |
| PubMed: | Efficient synthesis of highly substituted Pyrrolin-4-ones via PIFA-mediated cyclization reactions of enaminones. |
| PubMed: | Methanolysis as a route to gallium(III) clusters: synthesis and structural characterization of a decanuclear molecular wheel. |
| PubMed: | Ion-pair solid-phase extraction and gas chromatography-mass spectrometric determination of acidic hydrolysis products of chemical warfare agents from aqueous samples. |
| PubMed: | In situ synthesis of trisubstituted methanol ligands and their potential as one-pot generators of cubane-like metal complexes. |
| PubMed: | A FMO-controlled reaction path in the benzil-benzilic acid rearrangement. |
| PubMed: | The hexacoordinate silicate dianions mer-tris[glycolato(2-)-O(1),O(2)]silicate and fac-tris[benzilato(2-)-O(1),O(2)]silicate: syntheses and structural characterization. |
| PubMed: | Influence of pyrolytic and aqueous-phase reactions on the mechanism of formation of Maillard products. |
| PubMed: | Correction of the stereochemical assignment of the benzilic acid center in (R)-(-)-3-quinuclidinyl (S)-(+)-4-iodobenzilate [(R,S)-4-IQNB]. |
| PubMed: | New catalytic roles for serine esterases: a 19F-NMR study of the interaction of 3,3,3-trifluoro-2,2-dihydroxy-1-phenyl-1-propanone with chicken liver carboxylesterase. |
| PubMed: | Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates. |
| PubMed: | Bromopropylate: induction of hepatic cytochromes P450 and absence of covalent binding to DNA in mouse liver. |
| PubMed: | A novel and highly sensitive catalytic method for the determination of ultratrace amounts of gold in ores with linear scan voltammetry at a DME. |
| PubMed: | Determination of 3-quinuclidinyl benzilate (QNB) and its major metabolites in urine by isotope dilution gas chromatography/mass spectrometry. |
| PubMed: | [Mode of inhibitory action of propiverine hydrochloride on the micturition movements of the bladder in dogs]. |
| PubMed: | [Effect of propiverine hydrochloride on the function of the bladder in dogs]. |
| PubMed: | [Biotransformation of denaverin (Spasmalgan) in the rat]. |
| PubMed: | [The biotransformation of propiverin hydrochloride (Mictonorm)]. |
| PubMed: | [The spasmolytic activity of propiverine and some of its structural analogs]. |
| PubMed: | [Analysis and stability of propiverine hydrochloride (Mictonorm)]. |
| PubMed: | Pharmacology of the anticholinergic bronchospasmolytic agent flutropium bromide. |
| PubMed: | Molecular and crystal structure of flutropium bromide. |
| PubMed: | Synthesis of the bronchospasmolytic agent flutropium bromide and of some homologous and configuration isomeric compounds. |
| PubMed: | Pathways of decomposition of propylbenzilylcholine mustard in neutral and alkaline solution. |
| PubMed: | Affinity labeling of muscarinic receptors in rat cerebral cortex with a photolabile antagonist. |
| PubMed: | Influence of various phenolic compounds on Azotobacter. |
| PubMed: | syn-anti Isomerization in testosterone 17-enanthate 3-benzilic acid hydrazone. |
| PubMed: | Stability-indicating analysis of injectable estrogen-androgen combinations in formulations containing corn oil. |
| PubMed: | Preliminary screening of anticholinergic effect of some new derivatives of glycolic and aminoacetic acids. |
| PubMed: | In vivo and in vitro studies on the antimuscarinic activity of some amino esters of benzilic acid. |
| PubMed: | [Analytical study of new anticholinergic substances. II. Methods for the determination of 3-quinuclidylester chloride of benzilic acid]. |
| PubMed: | Nonoxidative enzymes in the metabolism of insecticides. |
| PubMed: | [Studies on the absorption of benzilic acid esters of homologous dimethyl-(2-hydroxyethyl)-alkylammonium bromides through buccal mucosa. 5th communication: On optimum bioavailability of homologous quaternary ammonium compounds (author's transl)]. |
| PubMed: | Nonoxidative enzymes in the metabolism of insecticides. |
| PubMed: | [Optimating the availability of homologous quaternary ammonium compounds/3rd communication: The influence of salts on in vitro distribution of benzilic acid esters of homologous dimethyl-(2-hydroxyethyl)-alkyl-ammoniumbromides (author's transl)]. |
| PubMed: | [The optimization of the availability of homologous quaternary ammonium compounds. 2. In vitro studies on the partition of homologous benzilic acid esters of dimethyl-(2-hydroxyethyl)-alkylammonium bromides]. |
| PubMed: | [The optimization of availability of homologous quaternary ammonium compounds. 1. Physico-chemical properties and ion-pair dissociation of homologous benzilic acid esters of dimethyl (2-hydroxyethyl)alkylammonium bromides]. |
| PubMed: | [A-nortriterpenoids by benzilic acid rearrangement (author's transl)]. |
| PubMed: | Determination of scandium by precipitation with benzilic acid. |
| PubMed: | [Identification of benzilic acid esters]. |
| PubMed: | 14C-tracer studies in the benzilic acid type rearrangement of 1-phenyl- and 1-(4-methoxyphenyl)-2-(3-pyridyl) glyoxal. |
| PubMed: | [Extraction-photometric determination of derivatives of benzilic acid I]. |
| PubMed: | The structure of the benzilic acid rearrangement product of 3-alpha, 7-beta-diacetoxy-11-hydroxy-12-oxo-5-beta-androst-9(11)-ene. An unusual structure with three five-membered rings cis-fused. |
| PubMed: | [Changes of ventilation and respiratory work in obstructive ventilation disorders through a new bronchodilator substance, benzilic acid--(N,N-dimethyl-2-hydroxymethylpiperidinium)estermethylsulfate]. |
| PubMed: | [Experiences with the new spasmo-analgetic benzilic acid-(N,N-dimethyl-2-hydroxymethylpiperidinium)estermethylsulfate in combination with the analgetic metamizol in a clinical department]. |
| PubMed: | [Cystometric studies with benzilic acid-(N,N-dimethyl-2-hydroxymethylpiperidinium)estermethylsulfate]. |
| PubMed: | [The effect of the new spasmolytic benzilic acid-(N,N-dimethyl-2-hydroxymethylpiperidinium)estermethylsulfate on the acidity content of the stomach]. |
| PubMed: | [Studies on the effect of benzilic acid-(N,N-dimethyl-2-hydroxymethylpiperidinium)estermethylsulfate on the tone and motility of the human intestinal tract]. |
| PubMed: | [The effect of benzilic acid-(N,N-dimethyl-2-hydroxymethylpiperidinium)estermethylsulfate on the hemodynamics of the anesthestized cat]. |
| PubMed: | [On the behavior of benzilic acid-(N,N-dimethyl-2-hydroxymethylpiperidinium)estermethylsulfate in the organism]. |
| PubMed: | [Pharmacologic and toxicologic studies on benzilic acid-(N,N-dimethyl-2-hydroxymethylpiperidinium)estermethylsulfate--a new spasmolytic]. |
| PubMed: | [The testing of the new spasmolytic benzilic acid-(N,N-dimethyl-2-hydroxymethylpiperidinium)estermethylsulfate in the clinic and practice]. |
| PubMed: | [The irritable bladder as a test object for spasmolytics. Experimental and clinical testing of benzilic acid-(N,N-dimethyl-2-hydroxymethylpiperidinium)estermethylsulfate]. |
| PubMed: | [Kinetics of decomposition of benzilic acid esters. 3. Study of kinetics of decomposition of benactyzine hydrochloride and methyliodide and diphemin hydrochloride]. |
| PubMed: | [Kinetics of decomposition of benzilic acid esters. II. Spectrophotometric determination of the esters in solutions containing decomposition products]. |
| PubMed: | [ATTEMPT AT A BENZILIC ACID OF PHENYL-ANTIPYRYL KETONE]. |
| PubMed: | STUDIES ON CENTRAL NERVOUS SYSTEM DEPRESSANTS. (VI). CENTRAL NERVOUS SYSTEM ACTIONS OF THREE ESTERS OF BENZILIC ACID. |
| PubMed: | [ON THE PHARMACOLOGY OF A SERIES OF NEW BENZILIC ACID DERIVATIVES. V. CARDIAC AND CIRCULATORY EFFECTS, AS WELL AS FURTHER PERIPHERAL AND CENTRAL EFFECTS; CHRONIC TOXICITY]. |
| PubMed: | [THE CHOLINOLYTIC ACTIVITY AND SOME PHYSICO-CHEMICAL PROPERTIES OF ALKYLAMINOETHYL ESTERS OF BENZILIC ACID]. |
| PubMed: | [ON THE PHARMACOLOGY OF A NEW SERIES OF NEW BENZILIC ACID DERIVATIVES. IV. ON THE EFFECT ON THE AGGRESSIVE STATE OF ALBINO RATS AND FIGHTING FISH]. |
| PubMed: | [ON THE PHARMACOLOGY OF A SERIES OF NEW BENZILIC ACID DERIVATIVES. III. ON THE EFFECT ON CONDITIONED FLIGHT REFLEX IN ALBINO RATS]. |
| PubMed: | [ON THE PHARMACOLOGY OF A SERIES OF NEW BENZILIC ACID DERIVATIVES. II. SPASMOLYTIC EFFECTIVENESS IN VITRO AND IN VIVO]. |
| PubMed: | [On the pharmacology of a series of new benzilic acid derivatives. I. Toxicity, analgesic activity and other effects on the central nervous system]. |
| PubMed: | Studies on the application of the benzilic acid rearrangement to the preparation of a-norsteroids. |
| PubMed: | [Research on the effect of the beta-dimethyloctylammonium ethyl ester bromide of benzilic acid on the cerebral blood vessels]. |
| PubMed: | [Effect of "loading" the dialkylaminoethyl radical on the pharmacological properties of benzilic acid esters]. |
| PubMed: | [Pharmacological properties of the dimethyloctylammoniumethyl ester of benzilic acid]. |
| PubMed: | [Studies on spasmolytics. V. Benzilic acid esters]. |
| PubMed: | Benzilic acid diethylaminoethylester hydrochloride (phobex) in the treatment of chronically psychotic patients. |
| PubMed: | [Pharmacological properties of benzilic acid 2-diethylaminoethyl ester (benactyzine), substances used in the treatment of anxiety states]. |
| PubMed: | Phramacological properties of esters of 1-alkyl-2-hydroxyalkylpyrrolidine and their quaternary derivatives. |
| PubMed: | [A new treatment of psychoneuroses; benzilic acid 2-diethylaminoethyl ester]. |
| PubMed: | On the effect of suavitil (benzilic acid diethylaminoethylester hydrochloride) on the higher mental functions of normal subjects. |
| PubMed: | The autonomic reaction of psycho-neurotics to a new sedative: benactyzine NFN, suavitil (R) (benzilic acid diethylaminoethylester hydrochloride). |
| PubMed: | The general pharmacology of benzilic acid diethylaminoethylester hydrochloride (benactyzine NFN, suavitil, parasan). |
| PubMed: | The effect of benzilic acid diethylaminoethylester HCl (benactyzine) on stress-induced behaviour in the rat. |
| PubMed: | [Pharmacological properties and clinical effects of the hydrochloride of the benzilic acid ester of tropine]. |
| PubMed: | [Research on the parasympatholytic activity of benzilic acid derivatives]. |
| PubMed: | Pharmacology of benzilic acid derivatives. |
| PubMed: | [Alkamine ester of benzilic acid as a spasmolytic]. |
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