allyl amine
2-propenylamine
 
Notes:
possesses an unusual and selective cytotoxicity for vascular smooth muscle cells in dogs and rats. useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.
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CAS Number: 107-11-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 203-463-9
FDA UNII: 48G762T011
Nikkaji Web: J4.053C
Beilstein Number: 0635703
MDL: MFCD00054329
XlogP3: 0.10 (est)
Molecular Weight: 57.09579000
Formula: C3 H7 N
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.76100 @  25.00 °C.
Refractive Index: 1.42030 @  20.00 °C.
Melting Point: -88.20 °C. @ 760.00 mm Hg (est)
Boiling Point: 53.30 °C. @ 760.00 mm Hg
Vapor Pressure: 246.700000 mmHg @ 25.00 °C. (est)
Vapor Density: 2.0 ( Air = 1 )
Flash Point: -20.00 °F. TCC ( -28.89 °C. )
logP (o/w): 0.030
Soluble in:
 water, 1.00E+06 mg/L @ 20 °C (exp)
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Shandong Luyue Chemical
Allylamine
Sigma-Aldrich: Aldrich
For experimental / research use only.
Allylamine 98%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mammal (species unspecified) LD50  78300 ug/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.

unreported-mammal (species unspecified) LD50  783 mg/kg
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.

intraperitoneal-mouse LD50  49 mg/kg
LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives of Environmental Health. Vol. 1, Pg. 343, 1960.

oral-mouse LD50  57 mg/kg
Archives of Environmental Health. Vol. 1, Pg. 343, 1960.

oral-rat LD50  102 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 17, 1982.

intraperitoneal-rat LDLo  37500 ug/kg
Farmakologiya i Toksikologiya Vol. 31, Pg. 238, 1968.

Dermal Toxicity:
skin-rabbit LD50 35 mg/kg
SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Archives of Environmental Health. Vol. 1, Pg. 343, 1960.

Inhalation Toxicity:
inhalation-mammal (species unspecified) LC50 320 mg/m3
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.

inhalation-man TCLo 2500 ppb/5M
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
Archives of Environmental Health. Vol. 1, Pg. 343, 1960.

inhalation-rat LC50 177 ppm/8H
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives of Environmental Health. Vol. 1, Pg. 343, 1960.

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Safety in Use Information:
Category: information only not used for fragrances or flavors
Recommendation for allyl amine usage levels up to:
 not for fragrance use.
 
Recommendation for allyl amine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
NIOSH International Chemical Safety Cards: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 107-11-9
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7853
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 prop-2-en-1-amine
Chemidplus: 0000107119
EPA/NOAA CAMEO: hazardous materials
RTECS: 107-11-9
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References:
 prop-2-en-1-amine
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 107-11-9
Pubchem (cid): 7853
Pubchem (sid): 134972252
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2921.19.5000
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
grade: cp chemically pure, technical.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 allylamine
 allylamine [UN2334] [Poison]
3-amino-1-propene
3-aminopropene
3-aminopropylene
 prop-2-en-1-amine
2-propen-1-amine
2-propen-1-ylamine
2-propenamine
2-propenylamine
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Articles:
PubMed: A Smart Drug Delivery System Based on Biodegradable Chitosan/Poly(allylamine hydrochloride) Blend Films
PubMed: Investigation of the Cytotoxicity of Electrospun Polysuccinimide-Based Fiber Mats
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PubMed: Soft nanotechnology: the potential of polyelectrolyte multilayers against E. coli adhesion to surfaces
PubMed: Covalent Adduct Formation Between Flavor Compounds of Various Functional Group Classes and the Model Protein ?-Lactoglobulin
PubMed: Exothermic-Endothermic Transition in the Titration of Poly(allylamine chloride) with Sodium Hexametaphoshate Associated with a Change in the Proton Release Regime
PubMed: Preparation and characterization of magnetic allylamine modified graphene oxide-poly(vinyl acetate-co-divinylbenzene) nanocomposite for vortex assisted magnetic solid phase extraction of some m
PubMed: Pre-grafted Group on PE Surface by DBD Plasma and Its Influence on the Oxygen Permeation with Coated SiOx
PubMed: Clinical efficacy of colesevelam in type 2 diabetes mellitus
PubMed: Polyamine-Modified Magnetic Graphene Oxide Nanocomposites and HPLC-MS/MS Allow the Determination of Two Indolic Derivatives in Strong-Aroma Types of Base Baijiu
PubMed: Expanded colesevelam administration options with oral suspension formulation for patients with diabetes and hypercholesterolemia
PubMed: Colesevelam hydrochloride for the treatment of type 2 diabetes mellitus
PubMed: Adsorption of Wine Constituents on Functionalized Surfaces
PubMed: Magnetic separation technology: Functional group efficiency in the removal of haze-forming proteins from wines
PubMed: Recent and emerging therapeutic medications in type 2 diabetes mellitus: incretin-based, Pramlintide, Colesevelam, SGLT2 Inhibitors, Tagatose, Succinobucol
PubMed: Glucose and low-density lipoprotein cholesterol lowering in elderly patients with type 2 diabetes: focus on combination therapy with colesevelam HCl
PubMed: A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus
PubMed: Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence
PubMed: Modulating LDL cholesterol and glucose in patients with type 2 diabetes mellitus: targeting the bile acid pathway
PubMed: [Determination of isothiocyanates and related compounds in mustard extract and horseradish extract used as natural food additives]
PubMed: Comparative evaluation of in vitro efficacy of colesevelam hydrochloride tablets
PubMed: Impedimetric sensor for toxigenic Penicillium sclerotigenum detection in yam based on magnetite-poly(allylamine hydrochloride) composite
PubMed: Validated UPLC method for determination of unbound bile acids in colesevelam HCl tablets
PubMed: Layer-by-Layer Thin Film of Iron Phthalocyanine as a Simple and Fast Sensor for Polyphenol Determination in Tea Samples
PubMed: Characterization of products from the reaction of glucosinolate-derived isothiocyanates with cysteine and lysine derivatives formed in either model systems or broccoli sprouts
PubMed: An analysis of the impact of FDA's guidelines for addressing cardiovascular risk of drugs for type 2 diabetes on clinical development
PubMed: Dietary administration of colesevelam hydrochloride does not affect fertility or reproductive performance in rats
PubMed: From the Food and Drug Administration
PubMed: Polyamine-guided synthesis of anisotropic, multicompartment microparticles
PubMed: Modified insulator semiconductor electrode with functionalized nanoparticles for Proteus mirabilis bacteria biosensor development
PubMed: Use of Amphoteric Copolymer Films as Sacrificial Layers for Constructing Free-Standing Layer-by-Layer Films
PubMed: Microencapsulation of yeast cells and their use as a biocatalyst in organic solvents
PubMed: [Safety of animal husbandry products produced by using allyl isothiocyanate-preserved feeds]
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