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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 245.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 450.12 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 349.00 °F. TCC ( 176.30 °C. ) (est)
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| logP (o/w): | 3.620 |
| Soluble in: |
| | water, 84.55 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for 7-hydroxyflavone usage levels up to: | | | not for fragrance use.
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| Recommendation for 7-hydroxyflavone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 7-hydroxy-2-phenyl- | | | flavone, 7-hydroxy- | | 7- | hydroxy flavone | | 7- | hydroxy-2-phenyl-4-benzopyrone | | 7- | hydroxy-2-phenyl-4H-chromen-4-one | | 7- | hydroxy-2-phenyl-chromen-4-one | | 7- | hydroxy-2-phenylchromen-4-one | | 7- | hydroxy-2-phenylchromone | | 7- | hydroxy-flavone |
Articles:
| PubMed: | Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells. |
| PubMed: | Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. |
| PubMed: | 7-hydroxyflavone revisited: spectral, acid-base properties, and interplay of the protolytic forms in the ground and excited states. |
| PubMed: | Inhibition of Enterovirus 71 replication by 7-hydroxyflavone and diisopropyl-flavon7-yl Phosphate. |
| PubMed: | Differences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagens. |
| PubMed: | Natural potential therapeutic agents of neurodegenerative diseases from the traditional herbal medicine Chinese dragon's blood. |
| PubMed: | Simultaneous quantitation of 5- and 7-hydroxyflavone antioxidants and their binding constants with BSA using dual chiral capillary electrophoresis (dCCE) and HPLC with fluorescent detection. |
| PubMed: | Urease inhibitory constituents from Daphne retusa. |
| PubMed: | Identification of a novel flavonoid glycoside sulfotransferase in Arabidopsis thaliana. |
| PubMed: | Evaluation of estrogenic potential of flavonoids using a recombinant yeast strain and MCF7/BUS cell proliferation assay. |
| PubMed: | Mutual regioselective inhibition of human UGT1A1-mediated glucuronidation of four flavonoids. |
| PubMed: | Identification and characterization of a novel kaempferol sulfotransferase from Arabidopsis thaliana. |
| PubMed: | Summation solute hydrogen bonding acidity values for hydroxyl substituted flavones determined by NMR spectroscopy. |
| PubMed: | Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition. |
| PubMed: | Influences of glucose on the dietary hydroxyflavonoid-plasma protein interaction. |
| PubMed: | Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. |
| PubMed: | Iron reduction potentiates hydroxyl radical formation only in flavonols. |
| PubMed: | Inhibitory effects and underlying mechanism of 7-hydroxyflavone phosphate ester in HeLa cells. |
| PubMed: | Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test. |
| PubMed: | Spectroscopic study of solvent effects on the electronic absorption spectra of flavone and 7-hydroxyflavone in neat and binary solvent mixtures. |
| PubMed: | Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. |
| PubMed: | Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison. |
| PubMed: | Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. |
| PubMed: | Comprehensive review of Clerodendrum phlomidis: a traditionally used bitter. |
| PubMed: | A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. |
| PubMed: | Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A. |
| PubMed: | Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. |
| PubMed: | Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites. |
| PubMed: | Mechanism of CYP2C9 inhibition by flavones and flavonols. |
| PubMed: | Ground and excited state proton transfer and antioxidant activity of 7-hydroxyflavone in model membranes: absorption and fluorescence spectroscopic studies. |
| PubMed: | Intestinal first-pass glucuronidation activities of selected dihydroxyflavones. |
| PubMed: | Protein engineering on biphenyl dioxygenase for conferring activity to convert 7-hydroxyflavone and 5,7-dihydroxyflavone (chrysin). |
| PubMed: | Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. |
| PubMed: | Empirically predicted 13C NMR chemical shifts for 8-hydroxyflavone starting from 7,8,4'-trihydroxyflavone and from 7,8-dihydroxyflavone. |
| PubMed: | [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60]. |
| PubMed: | Interaction of 7-hydroxyflavone with human serum albumin: a spectroscopic study. |
| PubMed: | A novel approach to the synthesis of 6-amino-7-hydroxy-flavone. |
| PubMed: | Antimetastatic potentials of flavones on oral cancer cell via an inhibition of matrix-degrading proteases. |
| PubMed: | Aromatase inhibition by bioavailable methylated flavones. |
| PubMed: | Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. |
| PubMed: | Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues. |
| PubMed: | Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1. |
| PubMed: | Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. |
| PubMed: | [Study on the non-covalent interaction of 7-hydroxy flavone and its phosphate with DNA by fluorescence method]. |
| PubMed: | Effect of different flavonoids on collagen synthesis in human fibroblasts. |
| PubMed: | Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones. |
| PubMed: | Characterization of polyphenols from plant materials through their silylation and 29Si NMR spectroscopy-line assignment through 29Si, 13C spin-spin couplings. |
| PubMed: | Anti-inflammatory inhibition of endothelial cell adhesion molecule expression by flavone derivatives. |
| PubMed: | Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. |
| PubMed: | Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. |
| PubMed: | The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. |
| PubMed: | Manganese-based complexes of radical scavengers as neuroprotective agents. |
| PubMed: | 7-OH-flavone is sulfated in the human liver and duodenum, whereas 5-OH-flavone and 3-OH-flavone are potent inhibitors of SULT1A1 activity and 7-OH-flavone sulfation rate. |
| PubMed: | Effect of simple phenolic compounds on azoxymethane-induced aberrant crypt foci in rat colon. |
| PubMed: | Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements. |
| PubMed: | Evaluation of 7-hydroxy-flavones as inhibitors of oestrone and oestradiol biosynthesis. |
| PubMed: | No evidence for the in vivo activity of aromatase-inhibiting flavonoids. |
| PubMed: | Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD) as potential agents for prostatic cancer. |
| PubMed: | Role of ATP sensitive potassium channel on 7-hydroxy flavone induced antinociception and possible association with changes in glycaemic status. |
| PubMed: | Effects of flavonoids on the growth and cell cycle of cancer cells. |
| PubMed: | Aromatase and 17beta-hydroxysteroid dehydrogenase inhibition by flavonoids. |
| PubMed: | Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids. |
| PubMed: | Effects of flavonoids on aromatase activity, an in vitro study. |
| PubMed: | A chalcone glycoside from Clerodendron phlomidis. |
| PubMed: | Biochemical studies of a new class of alcohol dehydrogenase inhibitors from Radix puerariae. |
| PubMed: | Aromatase inhibition by flavonoids. |
| PubMed: | Flavone mutagenicity in Salmonella typhimurium: dependence on the pKM101 plasmid and excision-repair deficiency. |
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