Articles:
| None found yet. Try the PubMed Search. |
7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Notes:
a theophylline derivative with broncho- and vasodilator properties. it is used in the treatment of asthma, cardiac dyspnea, and bronchitis.
-
BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 479-18-5 Dyphylline >98% Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor
-
| CAS Number: | 479-18-5 |  3D/inchi
|
| Other(deleted CASRN): | 52756-53-3 | |
| ECHA EINECS - REACH Pre-Reg: | 207-526-1 | |
| FDA UNII: | 263T0E9RR9 | |
| Nikkaji Web: | J2.054K | |
| Beilstein Number: | 0284563 | |
| MDL: | MFCD00005759 | |
| XlogP3: | -1.80 (est) | |
| Molecular Weight: | 254.24638000 | |
| Formula: | C10 H14 N4 O4 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Appearance: | white solid (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 161.50 °C. @ 760.00 mm Hg |
| Boiling Point: | 589.60 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 591.00 °F. TCC ( 310.40 °C. ) (est) |
| logP (o/w): | -1.100 (est) |
| Soluble in: | |
| water, 3.33E+05 mg/L @ 25 °C (exp) | |
| water, 1.93e+004 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
skin conditioning |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Dyphylline >98%
Odor: characteristic Use: Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It acts as an adenosine receptor antagonist and phosphodiesterase inhibitor |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| 7-(2,3-Dihydroxypropyl)theophylline |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-mouse LD50 195 mg/kg Strahlentherapie. Vol. 127, Pg. 245, 1965. intravenous-mouse LD50 1080 mg/kg Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 288, 1970. oral-mouse LD50 1954 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 343, 1956. oral-rat LD > 400 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 35, Pg. 266, 1946. intravenous-rat LD50 860 mg/kg Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 1052 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 601, 1956. subcutaneous-rat LD50 1253 mg/kg Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | cosmetic ingredient for skin conditioning | ||
| Recommendation for dyphylline usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for dyphylline flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 479-18-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 3182 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione | |
| Chemidplus: | 0000479185 |
| RTECS: | XH5100000 for cas# 479-18-5 |
References:
| 7-(2,3-dihydroxypropyl)-1,3-dimethylpurine-2,6-dione | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 3182 |
| Pubchem (sid): | 134974003 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | D00691 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2933.90.9500 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •tablets (200 mg), elixir (100 mg15 ml), & ampuls (500 mg2 ml) are avail. •oral: elixir 100 mg15 ml; tablets 200 mg; tablets (timed-release) 400 mg. elixir 160 mg15 ml; tablets 200 & 400 mg. injection: soln 250 mgml in 2 & 10 ml containers. | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| aristophyllin | |
| asthmolysin | |
| astmamasit | |
| astrophyllin | |
| circain | |
| circair | |
| coronal | |
| coronarin | |
| corphyllin | |
| (1,2- | dihydroxy-3-propyl)thiophyllin |
| dihydroxypropyl theophylline | |
| 7-(2,3- | dihydroxypropyl)-1,3-dimethylpurine-2,6-dione |
| 7-(2,3- | dihydroxypropyl)-1,3-dimethylxanthine |
| 7-(2,3- | dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione |
| 7-(2,3- | dihydroxypropyl)theophylline |
| 7-(beta,gamma- | dihydroxypropyl)theophylline |
| dilor-400 | |
| 1,3- | dimethyl-7-(2,3-dihydroxypropyl)xanthine |
| 7-(2,3- | dioxypropyl)theophylline |
| diphyllin | |
| diphylline | |
| diprofillin | |
| diprofilline | |
| diprophyllin | |
| diprophylline | |
| diprophyllinum | |
| dipropylline | |
| droxine | |
| dyflex | |
| glyfyllin | |
| glyphyllin | |
| glyphylline | |
| glyphyllinum | |
| hiphyllin | |
| hyphylline | |
| liactemin | |
| lufyllin | |
| neophyl | |
| neophyllin | |
| neophyllin M | |
| neophylline | |
| neostenovasan | |
| neothylline | |
| neutrafil | |
| neutraphyllin | |
| neutraphylline | |
| propyphyllin | |
| protheophylline | |
| purifilin | |
| 1H- | purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl |
| 1H- | purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-, (+-)- |
| silbephyllin | |
| silbephylline | |
| solufilin | |
| solufyllin | |
| soluphyllin | |
| synthophylline | |
| tefilan | |
| teofen | |
| tesfen | |
| theal | |
| thefylan | |
| theophylline, 7-(2,3-dihydroxypropyl)- |