5-methoxysalicylic acid
benzoic acid, 2-hydroxy-5-methoxy-
 
Notes:
enhances intestinal absorption of insulin in rats. Isol. from Primula veris (cowslip) 5-Methoxysalicylic acid is an aminosalicylic acid that has been found to; enhance intestinal absorption of insulin in rats and insulin uptake into human red blood cells (PMID 6319944)
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      2612-02-4 2-Hydroxy-5-methoxybenzoic acid 98%
       
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      Product(s):
      M1254 5-Methoxysalicylic Acid >98.0%(HPLC)(T)
       
Synonyms   Articles   Notes   Search
CAS Number: 2612-02-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 220-037-8
Nikkaji Web: J26.970K
Beilstein Number: 2209647
MDL: MFCD00002459
XlogP3: 2.50 (est)
Molecular Weight: 168.14856000
Formula: C8 H8 O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 347.00 °C. @ 760.00 mm Hg (est)
Flash Point: 296.00 °F. TCC ( 146.50 °C. ) (est)
logP (o/w): 2.100 (est)
Soluble in:
 water, 2463 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
2-Hydroxy-5-methoxybenzoic acid 98%
Carbosynth
For experimental / research use only.
2-Hydroxy-5-methoxybenzoic Acid
EMD Millipore
For experimental / research use only.
2-Hydroxy-5-methoxybenzoic Acid
Santa Cruz Biotechnology
For experimental / research use only.
2-Hydroxy-5-methoxybenzoic acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
2-Hydroxy-5-methoxybenzoic acid 98%
TCI AMERICA
For experimental / research use only.
5-Methoxysalicylic Acid >98.0%(HPLC)(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for 5-methoxysalicylic acid usage levels up to:
 not for fragrance use.
 
Recommendation for 5-methoxysalicylic acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 2612-02-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 75787
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2-hydroxy-5-methoxybenzoic acid
Chemidplus: 0002612024
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References:
 2-hydroxy-5-methoxybenzoic acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 75787
Pubchem (sid): 135033644
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB01868
FooDB: FDB011959
Export Tariff Code: 2918.99.4700
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 castoreum
Search  PMC Picture
 primula veris
Search Trop  Picture
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Synonyms:
m-anisic acid, 6-hydroxy-
 benzoic acid, 2-hydroxy-5-methoxy-
2-hydroxy-5-methoxybenzoic acid
5-methoxy-2-hydroxybenzoic acid
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Articles:
PubMed: 5-Methoxysalicylic Acid Matrix for Ganglioside Analysis with Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.
PubMed: A thiophene-containing compound as a matrix for matrix-assisted laser desorption/ ionization mass spectrometry and the electrical conductivity of matrix crystals.
PubMed: In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations.
PubMed: DFT, FT-Raman and FT-IR investigations of 5-methoxysalicylic acid.
PubMed: Biochemical assays of immobilized oligonucleotides with mass spectrometry.
PubMed: Laser spectroscopic investigation of salicylic acids hydrogen bonded with water in supersonic jets: Microsolvation effects for excited state proton dislocation.
PubMed: Fast excited-state intramolecular proton transfer and subnanosecond dynamic stokes shift of time-resolved fluorescence spectra of the 5-methoxysalicylic acid/diethyl ether complex.
PubMed: Structural characterization of Mycobacterium tuberculosis lipoarabinomannans by the combination of capillary electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
PubMed: 5-Methoxysalicylic acid and spermine: a new matrix for the matrix-assisted laser desorption/ionization mass spectrometry analysis of oligonucleotides.
PubMed: Direct quantitative analysis of peptides using matrix assisted laser desorption ionization.
PubMed: Metabolism of Hydroxydibenzofurans, Methoxydibenzofurans, Acetoxydibenzofurans, and Nitrodibenzofurans by Sphingomonas sp. Strain HH69.
PubMed: Tryptic mapping of recombinant proteins by matrix-assisted laser desorption/ionization mass spectrometry.
PubMed: Pheromonal activity of single castoreum constituents in beaver,Castor canadensis.
PubMed: [Intestinal absorption of insulin with a new telemetric shuttle in dogs].
PubMed: Effects of sodium 5-methoxysalicylate on macromolecule absorption and mucosal morphology in a vascularly perfused rat gut preparation in vivo.
PubMed: Inhibition of gluconeogenesis by salicylate and 5-methoxysalicylate in liver of normal and alloxan-diabetic rats.
PubMed: High-performance liquid chromatographic determination of certain salicylates and their major metabolites in plasma following topical administration of a liniment to healthy subjects.
PubMed: Lymphatic transport of sodium cefoxitin in the presence of sodium 5-methoxysalicylate after injection into rat rectal connective tissue, femoral muscle and femoral vein.
PubMed: Effect of adjuvants on the rectal absorption and lymphatic uptake of pepleomycin in rats.
PubMed: Possible mechanism of uptake for several compounds in ionized form through human erythrocyte membrane.
PubMed: Salicylate-promoted permeation of cefoxitin, insulin and phenylalanine across red cell membrane. Possible mechanism.
PubMed: Enhancement of rectal absorption of insulin using salicylates in dogs.
PubMed: Enhanced small intestinal absorption of cefmetazole and cefoxitin in rats in the presence of non-surfactant adjuvants.
PubMed: Enhanced rectal bioavailability of polypeptides using sodium 5-methoxysalicylate as an absorption promoter.
PubMed: Enhanced intestinal absorption of insulin in rats in the presence of sodium 5-methoxysalicylate.
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