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Category: cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 171.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 320.50 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 298.00 °F. TCC ( 147.60 °C. ) (est)
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| logP (o/w): | 3.090 |
| Soluble in: |
| | water, 1.00E+04 mg/L @ 20 °C (exp) | | | water, 522.2 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LDLo 250 mg/kg "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 792, 1955.
oral-rat LD50 250 mg/kg Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 9, Pg. 164, 1973.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic ingredient for skin conditioning |
| Recommendation for 5-chlorosalicylic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for 5-chlorosalicylic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoic acid, 5-chloro-2-hydroxy- | | 5- | chloro salicylic acid | | 5- | chloro-2-hydroxybenzoic acid | | 5- | chloro-2-hydroxybenzoicacid | | 5- | chlorosalicyclic acid | | | chlorosalicylic acid | | 5- | chlorosalicylicacid | | 2- | hydroxy-5-chlorobenzoic acid | | | salicylic acid, 5-chloro- |
Articles:
| PubMed: | Salicylic acid and some of its derivatives as antibacterial agents for viscose fabric. |
| PubMed: | Effect of biological confinement on the photophysics and dynamics of a proton-transfer phototautomer: an exploration of excitation and emission wavelength-dependent photophysics of the protein-bound drug. |
| PubMed: | Fluorescence-based high-throughput screening assay for drug interactions with UGT1A6. |
| PubMed: | On the photophysics of 3,5,6-Trichlorosalicylic acid: spectroscopic study combined with Hartree-Fock and Density Functional Theory calculations. |
| PubMed: | Bismuth(III) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori. |
| PubMed: | Deciphering the photophysics of 5-chlorosalicylic acid: evidence for excited-state intramolecular proton transfer. |
| PubMed: | In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. |
| PubMed: | Transport evaluation of salicylic acid and structurally related compounds across Caco-2 cell monolayers and artificial PAMPA membranes. |
| PubMed: | Two angular dioxygenases contribute to the metabolic versatility of dibenzofuran-degrading Rhodococcus sp. strain HA01. |
| PubMed: | Guest-controlling effects on ER behaviors of beta-cyclodextrin polymer. |
| PubMed: | Effect of ion-exchange fiber structure on the binding and release of model salicylates. |
| PubMed: | New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1. |
| PubMed: | Degradation of chlorinated dibenzofurans and dibenzo-p-dioxins by two types of bacteria having angular dioxygenases with different features. |
| PubMed: | Synthesis and biological activity of new diarylalkenes. |
| PubMed: | Biodegradation pathway of 2-chlorodibenzo-p-dioxin and 2-chlorodibenzofuran in the biphenyl-utilising strain JB1. |
| PubMed: | Defense Responses in Infected and Elicited Cucumber (Cucumis sativus L.) Hypocotyl Segments Exhibiting Acquired Resistance. |
| PubMed: | Pretreatment of Parsley (Petroselinum crispum L.) Suspension Cultures with Methyl Jasmonate Enhances Elicitation of Activated Oxygen Species. |
| PubMed: | Structure-activity studies in E. coli strains on ochratoxin A (OTA) and its analogues implicate a genotoxic free radical and a cytotoxic thiol derivative as reactive metabolites. |
| PubMed: | Conditioning of Parsley (Petroselinum crispum L.) Suspension Cells Increases Elicitor-Induced Incorporation of Cell Wall Phenolics. |
| PubMed: | Mutagenic activity of 2-chloro-4-nitroaniline and 5-chlorosalicylic acid in Salmonella typhimurium: two possible metabolites of niclosamide. |
| PubMed: | Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action. |
| PubMed: | Microbial metabolism of chlorosalicylates: effect of prolonged subcultivation on constructed strains. |
| PubMed: | Microbial metabolism of chlorosalicylates: accelerated evolution by natural genetic exchange. |
| PubMed: | Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats. |
| PubMed: | Meseclazone, 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation. |
| PubMed: | Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models. |
| PubMed: | [Chronic toxicity of 4-chloroanilide of 5-chlorosalicylic acid (Arylide)]. |
| PubMed: | Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation. |
| PubMed: | Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats. |
| PubMed: | Absorption, distribution, and metabolic fate of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one in rats, dogs, and humans. |
| PubMed: | [Bactericidal effect of streptomycin on acid-fast bacilli in the presence of 4-chloroanilid of 5-chlorosalicylic acid]. |
| PubMed: | [Some pharmacological properties of 4-chloroanilide of 5-chlorosalicylic acid]. |
| PubMed: | [Binding of 4-chloroanilide of 5-chlorosalicylic acid by blood serum proteins and other protein substances. I. Qualitative methods for determination of the binding of arylid by protein substances]. |
| PubMed: | Structural studies on complexes. IV. Crystal structure of a 1:1 5-chlorosalicylic acid and theophylline complex. |
| PubMed: | [Toxicity of 4-chloroanilid of 5-chlorosalicylic acid (arylid) for various species of laboratory animals]. |
| PubMed: | [Effect of 5-chlorosalicylic acid, 4-chloroanilide on tubercle bacilli]. |
| PubMed: | [Effect of 4-chloroanilid of 5-chlorosalicylic acid on the viability of tubercle bacilli in vitro]. |
| PubMed: | [Effect of 4-chloroanilid of 5-chlorosalicylic acid on experimental tuberculosis in guinea pigs]. |
| PubMed: | [Effect of the 4-chloroanilide of 5-chlorosalicylic acid on the respiration of tubercle bacilli]. |
| PubMed: | [Effect of 4-chloroanilide of 5-chlorosalicylic acid in experimental tuberculosis of white mice]. |
| PubMed: | [EFFECT OF 4-CHLOROANILIDE OF 5-CHLOROSALICYLIC ACID ON MYCOBACTERIUM TUBERCULOSIS IN VITRO]. |
| PubMed: | [Treatment of epidermophytosis with the 2'-chloroanilide of 5-chlorosalicylic acid]. |
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