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5'-S-methyl-5'-thioadenosine
Notes:
5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. It is produced from S-adenosylmethionine mainly through the polyamine biosynthetic pathway, where it behaves as a powerful inhibitory product. MTA is metabolized solely by MTA-phosphorylase, to yield 5-methylthioribose-1-phosphate and adenine, a crucial step in the methionine and purine salvage pathways, respectively. Evidence suggests that MTA can affect cellular processes in many ways. For instance, MTA has been shown to influence regulation of gene expression, proliferation, differentiation and apoptosis (PMID 15313459). 5-Methylthioadenosine can be found in human urine. Elevated excretion appears in children with severe combined immunodeficiency syndrome (PMID 3987052) [HMDB]
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| CAS Number: | 2457-80-9 |  3D/inchi
|
| FDA UNII: | 634Z2VK3UQ | |
| Nikkaji Web: | J419.054H | |
| Beilstein Number: | 0042420 | |
| MDL: | MFCD00010533 | |
| XlogP3-AA: | -0.30 (est) | |
| Molecular Weight: | 297.33815000 | |
| Formula: | C11 H15 N5 O3 S | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Soluble in: | |
| water, 3607 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
skin conditioning |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| 5'-S-Methyl-5'-thioadenosine 0.98
Odor: characteristic Use: Methylthioadenosine, also known as MTA and 5'-Methylthioadenosine, is a naturally occurring sulfur-containing nucleoside present in all mammalian tissues. |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | cosmetic ingredient for skin conditioning | ||
| Recommendation for methylthioadenosine usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for methylthioadenosine flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 439176 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | |
| Chemidplus: | 0002457809 |
| RTECS: | AU7410000 for cas# 2457-80-9 |
References:
| (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 439176 |
| Pubchem (sid): | 135056035 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| KEGG (GenomeNet): | C00170 |
| HMDB (The Human Metabolome Database): | HMDB01173 |
| FooDB: | FDB022465 |
| YMDB (Yeast Metabolome Database): | YMDB00178 |
| Export Tariff Code: | 2934.90.5000 |
| ChemSpider: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| adenosine thiomethylpentose | |
| adenosine, 5'-S-methyl-5'-thio- | |
| (2R,3R,4S,5S)-2-(6- | aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol |
| 5- | deoxy-5-(methyl thio) adenosine |
| methyl thioadenosine | |
| 5'-S- | methyl-5'-thioadenosine |
| vitamin L2 |