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Category: indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white to pale yellow solid (est) |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 54.30 °C. @ 760.00 mm Hg
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| Boiling Point: | 285.00 to 286.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.002000 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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| logP (o/w): | 2.606 (est) |
| Soluble in: |
| | alcohol | | | water, 2000 mg/L @ 25 °C (exp) |
| Insoluble in: |
| | water |
Organoleptic Properties:
Odor Description: at 10.00 % in dipropylene glycol. | phenolic |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| 4-tert-Butylcatechol solution
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| Charkit Chemical |
| BUTYL CATECHOL,4-TERTIARY- 85% IN METHANOL
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| Charkit Chemical |
| BUTYL CATECHOL,4-TERTIARY-
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| Connect Chemicals |
| TBC (solid and methanol solution)
Odor: characteristic Use: TBC (tert-butyl catechol) polymerization inhibitor for monomers such as: styrene, vinyl toluene, vinyl acetate, vinyl chloride, butadiene, isoprene, chloroprene and several others. |
| OQEMA |
| 4-tert-Butyl Catechol
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| OQEMA |
| 4-tert-Butylcatechol 44% in toluene
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| Penta International |
| P-TERT-BUTYL CATECHOL 85% IN METHANOL
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| Penta International |
| P-TERT-BUTYL CATECHOL 85% IN WATER
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| Penta International |
| p-tert-BUTYL CATECHOL
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 4-tert-Butylcatechol
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| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 4-tert-Butylcatechol ≥98.0% (HPLC)
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| Silver Fern Chemical |
| tert-Butylcatechol (TBC)
Odor: characteristic Use: Tert-Butylcatechol (TBC) It is added as a stabilizer and an inhibitor of polymerization to butadiene, styrene, vinyl acetate and other reactive monomer streams. It can also be used as a stabilizer in the manufacture of polyurethane foam. |
| TCI AMERICA |
| For experimental / research use only. |
| 4-tert-Butylcatechol >98.0%(GC)
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| Vigon International |
| Butyl Catechol Para Tertiary
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Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | C N - Corrosive, Dangerous for the environment. |
R 21/22 - Harmful in contact with skin and if swallowed. R 34 - Causes burns. R 43 - May cause sensitisation by skin contact. R 51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. S 01/02 - Keep locked up and out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately. S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 2820 mg/kg AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
intravenous-mouse LD50 32 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07874
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| Dermal Toxicity: |
skin-rabbit LD50 630 ul/kg AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
skin-rat LDLo 2000 mg/kg SKIN AND APPENDAGES (SKIN): HAIR: OTHER
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) National Technical Information Service. Vol. OTS0571349
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | indirect food additives: adhesives and components of coatings |
| Recommendation for 4-tert-butyl catechol usage levels up to: | | | not for fragrance use.
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| Recommendation for 4-tert-butyl catechol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzene-1,2-diol, 4-t-butyl- | | 1,2- | benzenediol, 4-(1,1-dimethylethyl)- | | p-tert- | butyl catechol | | 4-tert- | butyl pyrocatechol | | 4-tert- | butyl-1,2-benzenediol | | 4-tert- | butyl-1,2-dihydroxybenzene | | 4-tert- | butyl-benzene-1,2-diol | | 4-tert- | butyl-pyrocatechol | | 4-(tert- | butyl)benzene-1,2-diol | | 4-tert- | butylbenzene-1,2-diol | | 4-tert- | butylcatechin | | 4-t- | butylcatechol | | 4-tert- | butylcatechol | | p-tert- | butylcatechol | | 4-t- | butylpyrocatechol | | 4-tert- | butylpyrocatechol | | p-t- | butylpyrocatechol | | p-tert- | butylpyrocatechol | | | catechol, 4-tert-butyl- | | 1,2- | dihydroxy-4-tert-butylbenzene | | 4-(1,1- | dimethylethyl)-1,2-benzenediol | | 4-(2- | methyl-2-propanyl)-1,2-benzenediol | | 4-(2- | methyl-2-propanyl)-1,2-benzoldiol | | | pyrocatechol, 4-tert-butyl- | | 4- | TBC |
Articles:
| PubMed: | Synthesis of hydroxyphthioceranic acid using a traceless lithiation-borylation-protodeboronation strategy. |
| PubMed: | Deuterium isotope effect on the suicide inactivation of tyrosinase in its action on o-diphenols. |
| PubMed: | Indirect inactivation of tyrosinase in its action on 4-tert-butylphenol. |
| PubMed: | Air oxygenation chemistry of 4-TBC catalyzed by chloro bridged dinuclear copper(II) complexes of pyrazole based tridentate ligands: synthesis, structure, magnetic and computational studies. |
| PubMed: | Discovery of a metalloenzyme-like cooperative catalytic system of metal nanoclusters and catechol derivatives for the aerobic oxidation of amines. |
| PubMed: | Partial purification and characterization of polyphenoloxidase from culinary-medicinal Royal Sun mushroom (the Himematsutake), Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae). |
| PubMed: | A microfluidic device based on a screen-printed carbon electrode with electrodeposited gold nanoparticles for the detection of IgG anti-Trypanosoma cruzi antibodies. |
| PubMed: | Kinetic cooperativity of tyrosinase. A general mechanism. |
| PubMed: | Radical chain reduction of alkylboron compounds with catechols. |
| PubMed: | Isolation and characterization of 4-tert-butylphenol-utilizing Sphingobium fuliginis strains from Phragmites australis rhizosphere sediment. |
| PubMed: | Discovery of a new tyrosinase-like enzyme family lacking a C-terminally processed domain: production and characterization of an Aspergillus oryzae catechol oxidase. |
| PubMed: | Fine-tuning of catalytic properties of catechol 1,2-dioxygenase by active site tailoring. |
| PubMed: | Multienzymatic-rotating biosensor for total cholesterol determination in a FIA system. |
| PubMed: | Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: inhibition of microglial neurotoxicity. |
| PubMed: | Indirect oxidation of the antitumor agent procarbazine by tyrosinase--possible application in designing anti-melanoma prodrugs. |
| PubMed: | Integrated microfluidic systems with an immunosensor modified with carbon nanotubes for detection of prostate specific antigen (PSA) in human serum samples. |
| PubMed: | Purification and characterization of alkylcatechol 2,3-dioxygenase from butylphenol degradation pathway of Pseudomonas putida MT4. |
| PubMed: | Effects of the immobilization supports on the catalytic properties of immobilized mushroom tyrosinase: a comparative study using several substrates. |
| PubMed: | Enzymatic oxidation of tert-butylcatechol in the presence of sulfhydryl compounds: Application to the amperometric detection of penicillamine. |
| PubMed: | A green method for the electroorganic synthesis of new 1,3-Indandione derivatives. |
| PubMed: | Indirect oxidation of amino acid phenylhydrazides by mushroom tyrosinase. |
| PubMed: | Direct immobilization of tyrosinase enzyme from natural mushrooms (Agaricus bisporus) on D-sorbitol cinnamic ester. |
| PubMed: | Calculating molar absorptivities for quinones: application to the measurement of tyrosinase activity. |
| PubMed: | Isolation of a latent polyphenol oxidase from loquat fruit (Eriobotrya japonica Lindl.): kinetic characterization and comparison with the active form. |
| PubMed: | Polyphenol oxidase from Dominga table grape. |
| PubMed: | Inhibition of peroxidase-catalyzed oxidation of 3,3 ,5,5 -tetramethylbenzidine by aminophenols. |
| PubMed: | A dopaquinone model that mimics the water addition step of cofactor biogenesis in copper amine oxidases. |
| PubMed: | Quantitative structure-activity relationship for the cleavage of C3/C4-substituted catechols by a prototypal extradiol catechol dioxygenase with broad substrate specificity. |
| PubMed: | Tyrosinase inhibitory activity of cucumber compounds: enzymes responsible for browning in cucumber. |
| PubMed: | [Inhibition of peroxidase oxidation of aromatic amines by substituted phenols]. |
| PubMed: | Polymeric enzyme mimics: catalytic activity of ribose-containing polymers for a phosphate substrate. |
| PubMed: | Solvent deuterium isotope effect on the oxidation of o-diphenols by tyrosinase. |
| PubMed: | Partial purification of latent persimmon fruit polyphenol oxidase. |
| PubMed: | Low-molecular-weight contact allergens in p-tert-butylphenol-formaldehyde resin. |
| PubMed: | Sensitizing capacity of some trimers in p-tert-butylphenol-formaldehyde resin. |
| PubMed: | Mechanistic implications of variable stoichiometries of oxygen consumption during tyrosinase catalyzed oxidation of monophenols and o-diphenols. |
| PubMed: | Heterotrinuclear Oxo-Bridged Fe(III)ORu(IV)OFe(III) Complexes of Ruthenium Porphyrin and Borylated Low-Spin Iron Dioximes(1). |
| PubMed: | Biological production of optically active muconolactones by Rhodococcus rhodochrous. |
| PubMed: | Tyrosinase action on monophenols: evidence for direct enzymatic release of o-diphenol. |
| PubMed: | Chromium(VI) reduction by catechol(amine)s results in DNA cleavage in vitro: relevance to chromium genotoxicity. |
| PubMed: | Proteolytic activation of latent Paraguaya peach PPO. Characterization of monophenolase activity. |
| PubMed: | EPR studies of chromium(V) intermediates generated via reduction of chromium(VI) by DOPA and related catecholamines: potential role for oxidized amino acids in chromium-induced cancers. |
| PubMed: | Stopped-flow and steady-state study of the diphenolase activity of mushroom tyrosinase. |
| PubMed: | Reversible sodium dodecyl sulfate activation of latent peach polyphenol oxidase by cyclodextrins. |
| PubMed: | Tyrosinase-mediated formation of a reactive quinone from the depigmenting agents, 4-tert-butylphenol and 4-tert-butylcatechol. |
| PubMed: | Kinetics of activation of latent mushroom (Agaricus bisporus) tyrosinase by benzyl alcohol. |
| PubMed: | Oxidation of 4-tert-butylcatechol and dopamine by hydrogen peroxide catalysed by horseradish peroxidase. |
| PubMed: | Patch-test reactions to plastic and glue allergens. |
| PubMed: | Hydroperoxidase activity of lipoxygenase in the presence of cyclodextrins. |
| PubMed: | Effect of 3-hydroxyanthranilic acid on mushroom tyrosinase activity. |
| PubMed: | Kinetic study of the suicide inactivation of latent polyphenoloxidase from iceberg lettuce (Lactuca sativa) induced by 4-tert-butylcatechol in the presence of SDS. |
| PubMed: | Screening of depigmenting compounds for the development of an alternate method of branding beef cattle. |
| PubMed: | Kinetics study of the oxidation of 4-tert-butylphenol by tyrosinase. |
| PubMed: | Calibration of a Clark-Type oxygen electrode by tyrosinase-catalyzed oxidation of 4-tert-butylcatechol. |
| PubMed: | Determination of 4-tert.-butylphenol and 4-tert.-butylcatechol in cosmetic products by reversed-phase high-performance liquid chromatography. |
| PubMed: | The interaction of L-DOPA melanin with p-tert-butylcatechol. |
| PubMed: | Inhibition of tyrosinase activity by 4-tert-butylcatechol and other depigmenting agents. |
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