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Category: antimicrobial agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 164.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 283.34 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 275.00 °F. TCC ( 134.90 °C. ) (est)
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| logP (o/w): | 3.850 |
| Soluble in: |
| | water, 28 mg/L @ 25 °C (exp) | | | water, 28.94 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 242 mg/kg BLOOD: HEMORRHAGE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES BG Chemie: Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals. Vol. 5, Pg. 29, 1993.
oral-mouse LD50 568 mg/kg PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
BLOOD: HEMORRHAGE
BEHAVIORAL: TREMOR BG Chemie: Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals. Vol. 5, Pg. 29, 1993.
intravenous-rat LD50 > 200 mg/kg BG Chemie: Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals. Vol. 5, Pg. 29, 1993.
oral-rat LD50 473 mg/kg BEHAVIORAL: ATAXIA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BG Chemie: Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals. Vol. 5, Pg. 29, 1993.
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| Dermal Toxicity: |
skin-rabbit LD50 > 900 mg/kg BG Chemie: Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals. Vol. 5, Pg. 29, 1993.
skin-rat LD50 300 mg/kg BG Chemie: Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals. Vol. 5, Pg. 29, 1993.
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| Inhalation Toxicity: |
inhalation-rat LC50 > 1900 mg/m3/4H United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0382-0440S
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Safety in Use Information:
| Category: | antimicrobial agents |
| Recommendation for 4-tert-butyl benzoic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for 4-tert-butyl benzoic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoic acid, 4- (1,1-dimethylethyl)- | | | benzoic acid, 4-(1,1-dimethylethyl)- | | | benzoic acid, 4-(tert-butyl)- | | | benzoic acid, 4-t-butyl- | | | benzoic acid, 4-tert-butyl- | | | benzoic acid, p-tert-butyl- | | 4-tert- | butyl-benzoic acid | | 4-tert- | butyl-benzoicacid | | 4-(tert- | butyl)benzoic acid | | 4-tert- | butylbenzoic acid | | p-tert- | butylbenzoic acid | | 4-tert- | butylbenzoicacid | | 4-(1,1- | dimethylethyl)benzoic acid | | 4-(2- | methyl-2-propanyl)benzoic acid | | | TBBA |
Articles:
| PubMed: | Evaluation of benzoic acid derivatives as sirtuin inhibitors. |
| PubMed: | Multilayered textile coating based on a β-cyclodextrin polyelectrolyte for the controlled release of drugs. |
| PubMed: | Programed nebulizing-gas pressure mode for quantitative capillary electrophoresis-mass spectrometry analysis of endocrine disruptors in honey. |
| PubMed: | Characterization of the antibacterial activity and the chemical components of the volatile oil of the leaves of Rubus parvifolius L. |
| PubMed: | Novel Bradykinin Analogues Modified in the N-Terminal Part of the Molecule with a Variety of Acyl Substituents. |
| PubMed: | Tetra-kis(μ-4-tert-butyl-benzoato)-κO:O,O';κO,O':O';κO:O'-bis-[aqua-bis-(4-tert-butyl-benzoato-κO,O')(4-tert-butyl-benzoic acid-κO)praseodymium(III)]. |
| PubMed: | FT-IR, FT-Raman, NMR and UV-vis spectra, vibrational assignments and DFT calculations of 4-butyl benzoic acid. |
| PubMed: | Tetra-kis(μ-4-tert-butyl-benzoato)-κO:O';κO,O':O';κO:O,O'-bis-[aqua-(4-tert-butyl-benzoato-κO,O')(4-tert-butyl-benzoic acid-κO)neodymium(III)]. |
| PubMed: | Determination of endocrine disruptors in honey by CZE-MS using restricted access materials for matrix cleanup. |
| PubMed: | A confirmatory method for the determination of phenolic endocrine disruptors in honey using restricted-access material-liquid chromatography-tandem mass spectrometry. |
| PubMed: | 4-tert-Butyl-amino-3-nitro-benzoic acid. |
| PubMed: | Binding of alkylphenols and alkylated non-phenolics to rainbow trout (Oncorhynchus mykiss) hepatic estrogen receptors. |
| PubMed: | Determination of endocrine-disrupting compounds in cereals by pressurized liquid extraction and liquid chromatography-mass spectrometry. Study of background contamination. |
| PubMed: | Determination of weakly acidic endocrine-disrupting compounds by liquid chromatography-mass spectrometry with post-column base addition. |
| PubMed: | Host-guest assembly of ligand systems for metal ion complexation. Synergistic solvent extraction of copper(II) and silver(I) by 1,4,8,11-tetrabenzyl-1,4,8,11-tetraazacyclodecane in combination with carboxylic acids. |
| PubMed: | Self-assembly directed by NH...O hydrogen bonding: new layered molecular arrays derived from 4-tert- butylbenzoic acid and aliphatic diamines. |
| PubMed: | Determination of endocrine disruptors in water after derivatization with N-methyl-N-(tert.-butyldimethyltrifluoroacetamide) using gas chromatography with mass spectrometric detection. |
| PubMed: | Hypoglycemic prodrugs of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid. |
| PubMed: | Micellar acid-base potentiometric titrations of weak acidic and/or insoluble drugs. |
| PubMed: | Effects of selenite on O2 consumption, glutathione oxidation and NADPH levels in isolated hepatocytes and the role of redox changes in selenite toxicity. |
| PubMed: | Inhibition of hepatic gluconeogenesis and lipogenesis by benzoic acid, p-tert.-butylbenzoic acid, and a structurally related hypolipidemic agent SC-33459. |
| PubMed: | Testicular function of men occupationally exposed to para-tertiary butyl benzoic acid. |
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