4-pentynoic acid, 6089-09-4

Articles:

PubMed:	Effective PHIP labeling of bioactive peptides boosts the intensity of the NMR signal.
PubMed:	Synthesis and evaluation of 2-amino-5-(4-[(18)F]fluorophenyl)pent-4-ynoic acid ([(18)F]FPhPA): a novel (18)F-labeled amino acid for oncologic PET imaging.
PubMed:	An economical and safe procedure to synthesize 2-hydroxy-4-pentynoic acid: A precursor towards 'clickable' biodegradable polylactide.
PubMed:	Concise stereoselective total synthesis of (+)-muricatacin and (+)-epi-muricatacin.
PubMed:	Parahydrogen-induced polarization of carboxylic acids: a pilot study of valproic acid and related structures.
PubMed:	Synthesis of molecularly encoded oligomers using a chemoselective "AB + CD" iterative approach.
PubMed:	Versatile on-resin synthesis of high mannose glycosylated asparagine with functional handles.
PubMed:	Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner.
PubMed:	In situ assembly of porous Au-paper electrode and functionalization of magnetic silica nanoparticles with HRP via click chemistry for Microcystin-LR immunoassay.
PubMed:	Au(I)/Ag(I)-catalyzed cascade approach for the synthesis of benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones.
PubMed:	Enantioselective apoptosis induction in histiocytic lymphoma cells and acute promyelocytic leukemia cells.
PubMed:	Vanadium bromoperoxidase from Delisea pulchra: enzyme-catalyzed formation of bromofuranone and attendant disruption of quorum sensing.
PubMed:	Preparation of peptide and other biomolecular conjugates through chemoselective ligations.
PubMed:	Short-time gene expression response to valproic acid and valproic acid analogs in mouse embryonic stem cells.
PubMed:	Covalent immobilization of redox protein via click chemistry and carbodiimide reaction: direct electron transfer and biocatalysis.
PubMed:	Preparation, 99mTc-labeling and biodistribution studies of a PNA oligomer containing a new ligand derivative of 2,2'-dipicolylamine.
PubMed:	Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction.
PubMed:	Heterogeneous catalysis of a copper-coated atomic force microscopy tip for direct-write click chemistry.
PubMed:	Cu(I)-catalyzed intramolecular cyclization of alkynoic acids in aqueous media: a "click side reaction".
PubMed:	Multiple effects of pentyl-4-yn-VPA enantiomers: from toxicity to short-term memory enhancement.
PubMed:	S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite s-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mouse model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further valproic acid hydroxamates and amides.
PubMed:	Increased replication of human cytomegalovirus in retinal pigment epithelial cells by valproic acid depends on histone deacetylase inhibition.
PubMed:	Differential enantioselective effects of pentyl-4-yn-valproate on spatial learning in the rat, and neurite outgrowth and cyclin D3 expression in vitro.
PubMed:	Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods.
PubMed:	Pharmacological properties of YM-57029, a novel platelet glycoprotein IIb/IIIa antagonist.
PubMed:	Infrared and Raman Spectra of a Single Resin Bead for Analysis of Solid-Phase Reactions and Use in Encoding Combinatorial Libraries.
PubMed:	Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe.
PubMed:	Prediction of embryotoxic effects of valproic acid-derivatives with molecular in vitro methods.
PubMed:	5-[4-(3,3-Dimethylbutoxycarbonyl)phenyl]-4-pentynoic acid and its derivatives inhibit ionotropic gamma-aminobutyric acid receptors by binding to the 4'-ethynyl-4-n-propylbicycloorthobenzoate site.
PubMed:	Formation of gamma-glutamylpropargylglycylglycine from propargylglycine in human blood and erythrocytes.
PubMed:	Inhibition effect of propargylglycine on human fibrosarcoma HT-1080 cell invasiveness.
PubMed:	Studies on the teratogen pharmacophore of valproic acid analogues: evidence of interactions at a hydrophobic centre.
PubMed:	Evaluation of the Teratogenic Potential of Valproic Acid Analogues in Transgenic Dictyostelium discoideum Strains.
PubMed:	Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: Application to valproic acid and related analogues of varying potency.
PubMed:	Stereoselective dysmorphogenicity of the enantiomers of the valproic acid analogue 2-N-propyl-4-pentynoic acid (4-yn-VPA): cross-species evaluation in whole embryo culture.
PubMed:	A new metabolite of proglypargylglycine, gamma-glutamylpropargylglycylglycine, in liver of D,L-propargylglycine-administered rats.
PubMed:	In vivo detoxification of cyanide by cystathionase gamma-lyase.
PubMed:	Validation of an in vitro teratology system using chiral substances: stereoselective teratogenicity of 4-yn-valproic acid in cultured mouse embryos.
PubMed:	Mechanisms of interaction of Escherichia coli threonine synthase with substrates and inhibitors.
PubMed:	The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice.
PubMed:	The enantioselective teratogenicity of 2-n-propyl-4-pentynoic acid (4-yn-VPA) is due to stereoselective intrinsic activity and not differences in pharmacokinetics.
PubMed:	Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms.
PubMed:	Determination of a new blood glucose-lowering agent in biological fluids by capillary gas chromatography using electron-capture detection.
PubMed:	On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic acid.
PubMed:	Hepatotoxic action of a poisonous mushroom, Amanita abrupta in mice and its toxic component.
PubMed:	Affinity labeling of D-amino acid oxidase with an acetylenic substrate.
PubMed:	Elevation of hepatic tyrosine 2-oxoglutarate aminotransferase in rats by 4-pentynoic acid, a hypoglycemic agent.
PubMed:	Antimetabolites produced by microorganisms. II. L-2-amino-4-pentynoic acid.
PubMed:	[Data on acetylenic carboxylic acids. XI. Unsaturated lactones of thio-4-pentynoic acid].