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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.99300 @ 25.00 °C.
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| Boiling Point: | 206.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.050000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 205.00 °F. TCC ( 96.11 °C. )
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| logP (o/w): | 1.097 (est) |
| Soluble in: |
| | water, 3.937e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-mouse LD50 310 mg/kg Experientia. Vol. 28, Pg. 1198, 1972.
oral-mouse LD50 640 mg/kg Experientia. Vol. 28, Pg. 1198, 1972.
intravenous-rat LD50 310 mg/kg Experientia. Vol. 28, Pg. 1198, 1972.
oral-rat LD50 534 mg/kg Experientia. Vol. 28, Pg. 1198, 1972.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for 4-methyl pyrazole usage levels up to: | | | not for fragrance use.
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| Recommendation for 4-methyl pyrazole flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | antizol | | | fomepizole | | 4- | methyl-1H-pyrazole | | 4- | methylpyrazole | | 4- | MP | | 1H- | pyrazole, 4-methyl- |
Articles:
| PubMed: | Identification of trans,trans-2,4-decadienal metabolites in mouse and human cells using liquid chromatography-mass spectrometry. |
| PubMed: | The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults. |
| PubMed: | The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. |
| PubMed: | The endogenous cannabinoid 2-arachidonoylglycerol is intravenously self-administered by squirrel monkeys. |
| PubMed: | Para-nitrophenol hydroxylation by fish liver microsomes: kinetics and effect of selective cytochrome P450 inhibitors. |
| PubMed: | In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken, and pigs. |
| PubMed: | Effect of lycopene on caspase-3 enzyme activation in liver of methanol-intoxicated rats: comparison with fomepizole. |
| PubMed: | [Application in veterinary and human clinical toxicology]. |
| PubMed: | Fomepizole: a critical assessment of current dosing recommendations. |
| PubMed: | Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21. |
| PubMed: | Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide. |
| PubMed: | Endocannabinoids link feeding state and auditory perception-related gene expression. |
| PubMed: | Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats. |
| PubMed: | Antidote review: fomepizole for methanol poisoning. |
| PubMed: | A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. |
| PubMed: | Pretreatment of CD-1 mice with 4-methylpyrazole blocks toxicity from the gamma-hydroxybutyrate precursor, 1,4-butanediol. |
| PubMed: | Reversal of delta 9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine. |
| PubMed: | Treatment of the alcohol intoxications: ethylene glycol, methanol and isopropanol. |
| PubMed: | The role of alcohols as solvents in the genotoxicity testing of alpha,beta-unsaturated ketones in the SOS chromotest. |
| PubMed: | Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice. |
| PubMed: | American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee. |
| PubMed: | Retinoic acid reverses ethanol-induced cardiovascular abnormalities in quail embryos. |
| PubMed: | Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology. |
| PubMed: | Ethyl carbamate metabolism: in vivo inhibitors and in vitro enzymatic systems. |
| PubMed: | In vivo inhibition of N-nitrosodimethylamine metabolism by 4-methylpyrazole: a model for endogenous nitrosation. |
| PubMed: | Acute inhibition by ethanol of intestinal absorption of glucose and hepatic glycogen synthesis on glucose refeeding after starvation in the rat. |
| PubMed: | An experimental model of self-intoxication in C57 mice. |
| PubMed: | Voluntary consumption of ethanol and its consequences in C57 mice treated with 4-methylpyrazole. |
| PubMed: | Uninterrupted prolonged ethanol oxidation as a main pathogenetic factor of alcoholic liver damage: evidence from a new liquid diet animal model. |
| PubMed: | Aldehyde dehydrogenase inhibitors and voluntary ethanol drinking by rats. |
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