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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 342.59 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 281.00 °F. TCC ( 138.60 °C. ) (est)
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| logP (o/w): | 2.680 |
| Soluble in: |
| | water, 717.7 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD > 1300 mg/kg BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: REGIDITY
BEHAVIORAL: ATAXIA Indian Journal of Pharmaceutical Sciences. Vol. 49, Pg. 77, 1987.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for 4-methoxycinnamic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for 4-methoxycinnamic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cinnamic acid, 4-methoxy- | | | cinnamic acid, p-methoxy- | | 4- | methoxy cinnamic acid | | p- | methoxycinnamic acid | | para- | methoxycinnamic acid | | | methoxycinnamic acid, para | | 3-(4- | methoxyphenyl)-2-propenoic acid | | 3-(4- | methoxyphenyl)acrylic acid | | 3-(4- | methoxyphenyl)prop-2-enoic acid | | 2- | propenoic acid, 3-(4-methoxyphenyl)- |
Articles:
| PubMed: | [Chemical constituents from the aerial part of Sibiraea angustata]. |
| PubMed: | Protective effect of p-methoxycinnamic acid, an active phenolic acid against 1,2-dimethylhydrazine-induced colon carcinogenesis: modulating biotransforming bacterial enzymes and xenobiotic metabolizing enzymes. |
| PubMed: | Eco-friendly methodology for efficient synthesis and scale-up of 2-ethylhexyl-p-methoxycinnamate using Rhizopus oryzae lipase and its biological evaluation. |
| PubMed: | Quantification of phenolic acids and their methylates, glucuronides, sulfates and lactones metabolites in human plasma by LC-MS/MS after oral ingestion of soluble coffee. |
| PubMed: | Effects of four commonly used UV filters on the growth, cell viability and oxidative stress responses of the Tetrahymena thermophila. |
| PubMed: | Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads. |
| PubMed: | In vitro evaluation of caffeoyl and cinnamoyl derivatives as potential prolyl oligopeptidase inhibitors. |
| PubMed: | Anticholinesterase activity of phenolic acids and their derivatives. |
| PubMed: | Four new antioxidant phenylpropanoid glycosides from Microlepia pilosissima. |
| PubMed: | Potential antiarrhythmic effect of methyl 3,4,5-trimethoxycinnamate, a bioactive substance from roots of polygalae radix: suppression of triggered activities in rabbit myocytes. |
| PubMed: | New flavane gallates isolated from the leaves of Plicosepalus curviflorus and their hypoglycemic activity. |
| PubMed: | The modulatory influence of p-methoxycinnamic acid, an active rice bran phenolic acid, against 1,2-dimethylhydrazine-induced lipid peroxidation, antioxidant status and aberrant crypt foci in rat colon carcinogenesis. |
| PubMed: | Energetics and structural properties, in the gas phase, of trans-hydroxycinnamic acids. |
| PubMed: | Mechanisms of p-methoxycinnamic acid-induced increase in insulin secretion. |
| PubMed: | Evaluation of antioxidant activity of isoferulic acid in vitro. |
| PubMed: | Synthesis and evaluation of novel tetrapropoxycalix[4]arene enones and cinnamates for protection from ultraviolet radiation. |
| PubMed: | Chemical constituents of Polygala tenuifolia roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia. |
| PubMed: | Natural products modulate Shigella-host-cell interaction. |
| PubMed: | [Chemical constituents from aerial part of Atractylodes macrocephala]. |
| PubMed: | A comparison of skin delivery of ferulic acid and its derivatives: evaluation of their efficacy and safety. |
| PubMed: | The genome-wide expression profile of Scrophularia ningpoensis-treated thapsigargin-stimulated U-87MG cells. |
| PubMed: | [Studies on chemical constituents in roots and rhizomes of Notopterygium incisum]. |
| PubMed: | Insulin-releasing properties of a series of cinnamic acid derivatives in vitro and in vivo. |
| PubMed: | Glyceridic esters of p-methoxycinnamic acid. A new sunscreen of the cinnamate class. |
| PubMed: | Insulin-secretagogue activity of p-methoxycinnamic acid in rats, perfused rat pancreas and pancreatic beta-cell line. |
| PubMed: | 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. |
| PubMed: | Antimicrobial phenolic derivatives from Dendranthema zawadskii var. latilobum Kitamura (Asteraceae). |
| PubMed: | Simultaneous determination of four active constituents in the roots of Scrophularia buergeriana by HPLC-DAD and LC-ESI-MS. |
| PubMed: | Production of stilbenoids and phenolic acids by the peanut plant at early stages of growth. |
| PubMed: | Enzymatic synthesis of cinnamic acid derivatives. |
| PubMed: | Synthesis and cosmetic whitening effect of glycosides derived from several phenylpropanoids. |
| PubMed: | Bioassay-guided isolation of a vasorelaxant active compound from Kaempferia galanga L. |
| PubMed: | Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and streptozotocin-induced diabetic rats. |
| PubMed: | Ferulic acid dimer inhibits lipopolysaccharide-stimulated cyclooxygenase-2 expression in macrophages. |
| PubMed: | A new sunscreen of the cinnamate class: synthesis and enzymatic hydrolysis evaluation of glyceryl esters of p-methoxycinnamic acid. |
| PubMed: | Quantitative changes of secondary metabolites of Matricaria chamomilla by abiotic stress. |
| PubMed: | E- and Z-p-methoxycinnamic acid from Aquilegia vulgaris. |
| PubMed: | Spectroscopic evidence of silica-lignin complexes: implications for treatment of non-wood pulp wastewater. |
| PubMed: | Anti-amnestic activity of E-p-methoxycinnamic acid from Scrophularia buergeriana. |
| PubMed: | Cytotoxic and xenoestrogenic effects via biotransformation of trans-anethole on isolated rat hepatocytes and cultured MCF-7 human breast cancer cells. |
| PubMed: | Molecular markers of anthropogenic activity in sediments of the Havel and Spree Rivers (Germany). |
| PubMed: | Catalytic hunsdiecker reaction of alpha,beta-unsaturated carboxylic acids: how efficient is the catalyst? |
| PubMed: | A practical procedure for the large-scale preparation of methyl (2R,3S)-3-(4-methoxyphenyl)glycidate, a key intermediate for diltiazem. |
| PubMed: | Hepatoprotective phenylpropanoids from Scrophularia buergeriana roots against CCl(4)-induced toxicity: action mechanism and structure-activity relationship. |
| PubMed: | Photosensitive dermatitis due to sunscreen allergy in a child. |
| PubMed: | Tyrosinase inhibitors of Pulsatilla cernua root-derived materials. |
| PubMed: | E-p-methoxycinnamic acid protects cultured neuronal cells against neurotoxicity induced by glutamate. |
| PubMed: | Saponins-mediated potentiation of cisplatin accumulation and cytotoxicity in human colon cancer cells. |
| PubMed: | Selective growth inhibitor toward human intestinal bacteria derived from Pulsatilla cernua root. |
| PubMed: | Synthesis of 1,7-bis(4-hydroxypenyl)-4-hydroxy-1,3-heptadiene-5-one, an antiplatelet diarylheptanoid from Alpinia blepharocalyx K. schum. |
| PubMed: | Neuroprotective phenylpropanoid esters of rhamnose isolated from roots of Scrophularia buergeriana. |
| PubMed: | A strategy for the asymmetric aminohomologation of alpha, beta-dihydroxy aldehydes: application to the synthesis of the southwest tripeptide segment of echinocandin B. |
| PubMed: | Induction of histone acetylation and growth regulation in eryrthroleukemia cells by 4-phenylbutyrate and structural analogs. |
| PubMed: | Immunochemical identification of hepatic protein adducts derived from estragole. |
| PubMed: | Polyamine levels in various tissues of rats treated with 3-hydroxy-4-methoxycinnamic acid and 3,4-dimethoxycinnamic acid. |
| PubMed: | Studies on the constituents of Ailanthus integrifolia. |
| PubMed: | Oligosaccharide microscale analysis by circular dichroic spectroscopy: reference spectra for chromophoric D-fructofuranoside derivatives. |
| PubMed: | Determination of plasma homovanillic acid by liquid chromatography with electrochemical detection. |
| PubMed: | Phenylpropanoid Metabolism in Suspension Cultures of Vanilla planifolia Andr. : III. Conversion of 4-Methoxycinnamic Acids into 4-Hydroxybenzoic Acids. |
| PubMed: | Oligosaccharide microanalysis by c.d. spectroscopy. Reference curves for D-mannose derivatives. |
| PubMed: | Chronic actinic dermatitis. Study of the spectrum of chronic photosensitivity in 12 patients. |
| PubMed: | The changing role of ultraviolet spectroscopy in drug analysis. |
| PubMed: | Substantivity of sunscreens: an appraisal of some quaternary ammonium sunscreens. |
| PubMed: | Chloroperoxidase-catalyzed halogenation of trans-cinnamic acid and its derivatives. |
| PubMed: | [Biliary excretion of choleretically active cinnamic acid derivatives in the rat]. |
| PubMed: | Some properties of p-coumarate decarboxylase from Cladosporium phlei. |
| PubMed: | Synthesis and pharmacology of p-methoxycinnamic acid derivatives. |
| PubMed: | [Light protective effects of esters & amides of p-methoxycinnamic acid. 2. Light-protective effects of alkyl esters of p-methoxycinnamic acid & of p-acylamino- and alkoxyphenylacylpyridinium salts]. |
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