4-hydroxypyridine
4-pyridone
 
Notes:
None found
  • BOC Sciences
    • BOC Sciences
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      Product(s):
      626-64-2 4-Hydroxypyridine
       
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    • TCI AMERICA
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      Product(s):
      H0332 4-Hydroxypyridine >99.0%(GC)
       
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CAS Number: 626-64-2Picture of molecule3D/inchi
Other(deleted CASRN): 811801-35-1
ECHA EINECS - REACH Pre-Reg: 210-958-3
FDA UNII: 3P2MV07G53
Nikkaji Web: J94.859D
Beilstein Number: 0105800
MDL: MFCD00040458
XlogP3: -1.30 (est)
Molecular Weight: 95.10105000
Formula: C5 H5 N O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 149.80 °C. @ 760.00 mm Hg
Boiling Point: 380.61 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.396000 mmHg @ 20.00 °C.
Flash Point: 360.00 °F. TCC ( 182.30 °C. ) (est)
logP (o/w): -1.300 (est)
Soluble in:
 water, 1.00E+06 mg/L @ 20 °C (exp)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
4-Hydroxypyridine
Santa Cruz Biotechnology
For experimental / research use only.
4-Hydroxypyridine
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-Hydroxypyridine 95%
TCI AMERICA
For experimental / research use only.
4-Hydroxypyridine >99.0%(GC)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  923 mg/kg
Toxicon. Vol. 23, Pg. 815, 1985.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
Recommendation for 4-hydroxypyridine usage levels up to:
 not for fragrance use.
 
Recommendation for 4-hydroxypyridine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 626-64-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 12290
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 1H-pyridin-4-one
Chemidplus: 0000626642
RTECS: UU7701450 for cas# 626-64-2
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References:
 1H-pyridin-4-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 12290
Pubchem (sid): 135025432
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
UM BBD: Search
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2933.39.9100
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
gamma-hydroxypyridine
 pyridin-4-ol
1H-pyridin-4-one
4-pyridinol
4-pyridone
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Articles:
PubMed: Synthesis, characterization and binding affinities of rhenium(I) thiosemicarbazone complexes for the estrogen receptor (α/β).
PubMed: The role of substrate strain in the mechanism of the carbon-carbon lyases.
PubMed: Switching the conductance of a molecular junction using a proton transfer reaction.
PubMed: The Flögel-three-component reaction with dicarboxylic acids - an approach to bis(β-alkoxy-β-ketoenamides) for the synthesis of complex pyridine and pyrimidine derivatives.
PubMed: An experimental and theoretical approach of spectroscopic and structural properties of a new chelidamate copper (II) complex.
PubMed: Syntheses, structures, properties and DFT study of hybrid inorganic-organic architectures constructed from trinuclear lanthanide frameworks and Keggin-type polyoxometalates.
PubMed: catena-Poly[[di-μ2-aqua-hexaaquabis(μ3-4-oxidopyridine-2,6-dicarboxylato)trimanganese(II)] trihydrate]: a new one-dimensional coordination polymer based on a trinuclear Mn(II) complex of chelidamic acid.
PubMed: Synthesis, structure and characterization of a helical seven-coordinated pyridine-2,6-dicarboxylate-bridged cadmium(II) complex.
PubMed: Synthesis of trans-(4-hydroxypyridine)(ammine)dichloroplatinum(II) and its activity in the human ovarian tumour models.
PubMed: Pseudopolymorphs of chelidamic acid and its dimethyl ester.
PubMed: Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.
PubMed: Simplified bicyclic pyridinol analogues protect mitochondrial function.
PubMed: 4-Pyridone-terephthalic acid-water (2/1/2) and bis(3-hydroxypyridinium) terephthalate.
PubMed: Decaaquabis(μ3-4-hydroxypyridine-2,6-dicarboxylato)bis(4-hydroxypyridine-2,6-dicarboxylato)tetramanganese(II) 3.34-hydrate: a new three-dimensional open metal-organic framework based on a tetranuclear Mn(II) complex of chelidamic acid and undecameric stitching water clusters.
PubMed: A practical two-step procedure for the preparation of enantiopure pyridines: Multicomponent reactions of alkoxyallenes, nitriles and carboxylic acids followed by a cyclocondensation reaction.
PubMed: A zeolitic porous lithium-organic framework constructed from cubane clusters.
PubMed: A three-component synthesis of beta-alkoxy-beta-keto-enamides--flexible precursors for 4-hydroxypyridine derivatives and their palladium-catalysed reactions.
PubMed: The effects of tautomerism on the nature of molecules in the solid state.
PubMed: Three-component synthesis of perfluoroalkyl- or perfluoroaryl-substituted 4-hydroxypyridine derivatives and their palladium-catalyzed coupling reactions.
PubMed: Studies on the synthesis and activity of three tripalladium complexes containing planaramine ligands.
PubMed: Synthesis, activity and binding with DNA of [{trans-PtCl(NH(3))(2)}(2)micro-{trans-Pd(4-hydroxypyridine) (2) (H(2)N(CH(2))(6)NH(2))(2)]Cl(4) (TH8).
PubMed: A new and flexible synthesis of 4-hydroxypyridines: rapid access to caerulomycins A, E and functionalized terpyridines.
PubMed: Coordination polymers with pyridine-2,4,6-tricarboxylic acid and alkaline-earth/lanthanide/transition metals: synthesis and X-ray structures.
PubMed: Construction of subphthalocyanine-porphyrin and subphthalocyanine-phthalocyanine heterodyads through axial coordination.
PubMed: Characterization of subdomain IIA binding site of human serum albumin in its native, unfolded, and refolded states using small molecular probes.
PubMed: Saccharide recognition-induced transformation of pyridine-pyridone alternate oligomers from self-dimer to helical complex.
PubMed: Sequential treatment with SN-38 followed by 5-fluorouracil shows synergistic cytotoxic activity in small cell lung cancer cells.
PubMed: A study on the inhibition of adenosine deaminase.
PubMed: Gas-phase tautomeric equilibrium of 4-hydroxypyrimidine with its ketonic forms: a free jet millimeterwave spectroscopy study.
PubMed: Studies on the activity of three palladium(II) compounds of the form: trans-PdL2Cl2 where L=2-hydroxypyridine, 3-hydroxypyridine, and 4-hydroxypyridine.
PubMed: Aminoacrylate intermediates in the reaction of Citrobacter freundii tyrosine phenol-lyase.
PubMed: Synthesis and characterization of metal-organic frameworks based on 4-hydroxypyridine-2,6-dicarboxylic acid and pyridine-2,6-dicarboxylic acid ligands.
PubMed: Reaction paths of tautomerization between hydroxypyridines and pyridones.
PubMed: Mn(II) staircase structures stitched by water clusters to a 3D metal-organic open framework: X-ray structural and magnetic studies.
PubMed: Synthesis, characterization and binding with DNA of four planaramineplatinum(II) complexes of the forms: trans-PtL2Cl2 and [PtL3Cl]Cl, where L = 3-hydroxypyridine, 4-hydroxypyridine and imidazo(1,2-alpha)pyridine.
PubMed: Synthesis and characterization of hydrogen-bonded assemblies of W6S8L6 clusters.
PubMed: Metal-ligand induced supramolecular polymerization: a route to responsive materials.
PubMed: Multistimuli, multiresponsive metallo-supramolecular polymers.
PubMed: Piericidins C5 and C6: new 4-pyridinol compounds produced by Streptomyces sp. and Nocardioides sp.
PubMed: 4-Hydroxypyridine-2,6-dicarboxylatodioxovanadate(V) complexes: solid state and aqueous chemistry.
PubMed: Calixarenes as scaffolds: introduction of tridentate rare earth metal binding units into calix[4]arene.
PubMed: Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm).
PubMed: Chemoenzymatic synthesis of isogalactofagomine.
PubMed: Comparative induction of CYP1A1 expression by pyridine and its metabolites.
PubMed: Ethylenediamine-palladium(II) complexes with pyridine and its derivatives: synthesis, molecular structure and initial antitumor studies.
PubMed: Persistent induction of apoptosis and suppression of mitosis as the basis for curative therapy with S-1, an oral 5-fluorouracil prodrug in a colorectal tumor model.
PubMed: Comparison of the effects of pyridine and its metabolites on rat liver and kidney.
PubMed: Effect of haloperidol and its metabolites on dopamine and noradrenaline uptake in rat brain slices.
PubMed: Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia.
PubMed: Binding of phenol and analogues to alanine complexes of tyrosine phenol-lyase from Citrobacter freundii: implications for the mechanisms of alpha,beta-elimination and alanine racemization.
PubMed: Validation of whole chick embryo cultures, whole rat embryo cultures and aggregating embryonic brain cell cultures using six pairs of coded compounds.
PubMed: Potential for carboxylation-dehydroxylation of phenolic compounds by a methanogenic consortium.
PubMed: New 4-hydroxypyridine and 4-hydroxyquinoline derivatives as inhibitors of NADH-ubiquinone reductase in the respiratory chain.
PubMed: [Presynaptic effects of aminopyridines on the neuromuscular junction of vertebrates].
PubMed: Rapid liquid chromatographic determination of clopidol in chicken muscles.
PubMed: Tissue residues of clopidol (3,5-dichloro-2,6-dimethyl-4-pyridinol) in chickens in relation to withdrawal times.
PubMed: Increase in transmitter release from motor nerve terminals induced by some pyridine derivatives.
PubMed: Synthesis of potential anticancer agents. Pyrido[4,3-b][1,4]oxazines and pyrido[4,3-b][1,4]thiazines.
PubMed: New broad-spectrum cephalosporins with anti-pseudomonal activity. II. Synthesis and antibacterial activity of 7 beta-[2-acylamino-2-(4-hydroxyphenyl)acetamido]-3-[ (1-methyl-1H-tetrazol-5-yl)thiomethyl]ceph-3-em-4-carboxylic acids.
PubMed: New broad-spectrum cephalosporins with anti-pseudomonal activity. I. Synthesis and antibacterial activity of 7 beta-[D-2-[(4-hydroxy-1,5-naphthyridine-3-carbonylamino)- and (4-hydroxypyridine-3-carbonylamino)]-2-(4-hydoxyphenyl)acetamido] cephalosporins.
PubMed: Metabolism of carcinogenic and non-carcinogenic N-nitroso-N-methylaminopyridines. II. Investigations in vivo.
PubMed: Vitamin K-dependent carboxylase. Partial purification and properties of the enzyme-substrate complex.
PubMed: Metabolism of carcinogenic and non-carcinogenic N-nitroso-N-methylaminopyridines. I. Investigations in vitro.
PubMed: In vitro inhibition of vitamin K dependent carboxylation by tetrachloropyridinol and the imidazopyridines.
PubMed: Microbial metabolism of the pyridine ring. The metabolism of pyridine-3,4-diol (3,4-dihydroxypyridine) by Agrobacterium sp.
PubMed: Microbial metabolism of the pyridine ring. The hydroxylation of 4-hydroxypyridine to pyridine-3,4-diol (3,4-dihydroxypyridine) by 4-hydroxypyridine-3-hydroxylase.
PubMed: Synthesis and anticoccidial activity of 3-fluoro-5-chloro- and -bromo-2,6-dimethyl-4-pyridinol.
PubMed: Microbial metabolism of the pyridine ring. Formation of pyridinediols (dihydroxypyridines) as intermediates in the degradation of pyridine compounds by micro-organisms.
PubMed: Antimalarial activity of clopidol, 3,5-dichloro-2,6-dimethyl-4-pyridinol, and its esters, carbonates, and sulfonates.
PubMed: Potency and coagulation factor effects of 2,3,5,6-tetrachloro-4-pyridinol compared to warfarin and its antagonism by vitamin K.
PubMed: 2,3,5,6-tetrachloro-4-pyridinol: a new chemical structure for anticoagulant activity.
PubMed: Inhibition of carotenoid synthesis as a mechanism of action of amitrole, dichlormate, and pyriclor.
PubMed: The metabolism of 4-hydroxypyridine by Agrobacterium sp.: a new ring cleavage of the pyridine nucleus.
PubMed: [Nitration of 2-methyl-4-hydroxypyridine and 2-methyl-4-ethoxypyridine].
PubMed: Fluorescence studies on some hydroxypyridines including compounds of the vitamin B6 group.
PubMed: [Synthesis of heterocyclic compounds with nitrogen. 98. Reaction of alpha-halogenated ketones with 3-nitro-4-hydroxypyridine and with 3-amino-4-hydroxypyridine].
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