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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Refractive Index: | 1.57500 @ 20.00 °C.
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| Melting Point: | 36.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 253.20 °C. @ 760.00 mm Hg (est)
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| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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| logP (o/w): | 1.990 (est) |
| Soluble in: |
| | water, 3060 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 2647 mg/kg SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: ATAXIA National Technical Information Service. Vol. OTS0540641
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for 4-chromanone usage levels up to: | | | not for fragrance use.
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| Recommendation for 4-chromanone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 2,3-dihydro- | | | chroman-4-one | | 2,3- | dihydrochromen-4-one |
Articles:
| PubMed: | Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin a and derivatives. |
| PubMed: | Design, synthesis and biological evaluation of 4-chromanone derivatives as IKr inhibitors. |
| PubMed: | Synthesis and in vitro cytotoxic activity of novel chalcone-like agents. |
| PubMed: | Prospects for flavonoid and related phytochemicals as nature-inspired treatments for Clostridium difficile infection. |
| PubMed: | Rhodium catalyzed oxidative coupling of salicylaldehydes with diazabicyclic olefins: a one pot strategy involving aldehyde C-H cleavage and π-allyl chemistry towards the synthesis of fused ring chromanones. |
| PubMed: | Cyclic chalcone analogue KRP6 as a potent modulator of cell proliferation: an in vitro study in HUVECs. |
| PubMed: | 3-Bromo-chroman-4-one. |
| PubMed: | Synthesis, in vitro antifungal evaluation and in silico study of 3-azolyl-4-chromanone phenylhydrazones. |
| PubMed: | Enantiomeric scaffolding of α-tetralone and related scaffolds by EKR (enzymatic kinetic resolution) and stereoselective ketoreduction with ketoreductases. |
| PubMed: | Anti-inflammatory activities of selected synthetic homoisoflavanones. |
| PubMed: | Highly efficient construction of spirocyclic chromanone-pyrrolidines via Cu(I)/TF-BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition. |
| PubMed: | A chromanone alkaloid from Derris ovalifolia stem. |
| PubMed: | Modulation of expression of IL-8 gene in bronchial epithelial cells by 5-methoxypsoralen. |
| PubMed: | Isolation and immunomodulatory effect of homoisoflavones and flavones from Agave sisalana Perrine ex Engelm. |
| PubMed: | [Chemical constitutents in fermental mycelium of Xylaria nigripes]. |
| PubMed: | Apralactone A and a New Stereochemical Class of Curvularins from the Marine-Derived Fungus Curvularia sp. |
| PubMed: | Carbonyl emissions from gasoline and diesel motor vehicles. |
| PubMed: | Bioactive alkenylphenols from Piper obliquum. |
| PubMed: | Protective effect of icariin on DNA against radical-induced oxidative damage. |
| PubMed: | Homoisoflavanones from Pseudoprospero firmifolium of the monotypic tribe Pseudoprospereae (Hyacinthaceae: Hyacinthoideae). |
| PubMed: | (+)-Silybin, a pharmacologically active constituent of Silybum marianum: fragmentation studies by atmospheric pressure chemical ionization quadrupole time-of-flight tandem mass spectrometry. |
| PubMed: | The hydrogenation/transfer hydrogenation network: asymmetric hydrogenation of ketones with chiral eta6-arene/N-Tosylethylenediamine-ruthenium(II) catalysts. |
| PubMed: | Synthesis and immunosuppressive activity of L-rhamnopyranosyl flavonoids. |
| PubMed: | Icariin: a special antioxidant to protect linoleic acid against free-radical-induced peroxidation in micelles. |
| PubMed: | Two unusual rotenoid derivatives, 7a-O-methyl-12a-hydroxydeguelol and spiro-13-homo-13-oxaelliptone, from the seeds of Derris trifoliata. |
| PubMed: | Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants. |
| PubMed: | Binding model construction of antifungal 2-aryl-4-chromanones using CoMFA, CoMSIA, and QSAR analyses. |
| PubMed: | The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis. |
| PubMed: | Concise synthesis of anti-HIV-1 active (+)-inophyllum B and (+)-calanolide A by application of (-)-quinine-catalyzed intramolecular oxo-Michael addition. |
| PubMed: | Crystal structure of the 4-chromanone derivative. |
| PubMed: | In vitro antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Aegle marmelos Correa. |
| PubMed: | Homoisoflavonoids and xanthones from the tubers of wild and in vitro regenerated Ledebouria graminifolia and cytotoxic activities of some of the homoisoflavonoids. |
| PubMed: | Development of novel pesticides based on phytoalexins: Part 2. Quantitative structure-activity relationships of 2-heteroaryl-4-chromanone derivatives. |
| PubMed: | Flavonoids and stilbenoids with COX-1 and COX-2 inhibitory activity from Dracaena loureiri. |
| PubMed: | Carbanion-induced base-catalyzed synthesis of 1H-isothiochromenes, benzo[c]thiochromenes through ring-transformation reactions of 6-aryl-2H-pyran-2-ones. |
| PubMed: | Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity. |
| PubMed: | Synthesis and pharmacological profile of novel N-substituted N-[5H-[1]benzopyrano[4,3-d]pyrimidin-2-YL]-N-methylglycinamides. |
| PubMed: | Potent inhibitors of acyl-CoA:cholesterol acyltransferase. Structure-activity relationships of novel N-(4-oxochroman-8-yl)amides. |
| PubMed: | Screening of unsubstituted cyclic compounds as inhibitors of monoamine oxidases. |
| PubMed: | Microbiological transformation of chromone, chromanone, and ring A hydroxyflavones. |
| PubMed: | Cycloaddition of dichloroketene to N,N-disubstituted 3-aminomethylene-5-hydroxy-2,2-dimethyl-7-pentyl-4-chromanone: synthesis of 2H,5H-pyrano[3,2-c][1]benzopyran derivatives. |
| PubMed: | Fragmentation of 3-oximino-4-chromanone. |
| PubMed: | 3-amino-4-chromanone hydrochlorides. |
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