Articles:
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4,4'-diaminodiphenyl sulphone
Notes:
None found
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 80-08-0 Dapsone >98% Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and immunomodulatory effects.
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| CAS Number: | 80-08-0 |  3D/inchi
|
| Other(deleted CASRN): | 1246638-15-2 | |
| ECHA EINECS - REACH Pre-Reg: | 201-248-4 | |
| FDA UNII: | 8W5C518302 | |
| Nikkaji Web: | J4.247A | |
| Beilstein Number: | 0788055 | |
| MDL: | MFCD00007887 | |
| XlogP3-AA: | 1.00 (est) | |
| Molecular Weight: | 248.30504000 | |
| Formula: | C12 H12 N2 O2 S | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| DG SANTE Food Contact Materials: | 4,4'-diaminodiphenyl sulphone |
Physical Properties:
| Appearance: | white crystalline powder crystalline powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Soluble in: | |
| water, 380mg/L @ 37 °C (exp) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Dapsone >98%
Odor: characteristic Use: Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and immunomodulatory effects. |
| Glentham Life Sciences |
| Dapsone |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 4-Aminophenyl Sulfone 97% |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-cat LDLo 357 mg/kg Archives of Neurology and Psychiatry. Vol. 54, Pg. 319, 1945. oral-child TDLo 5 mg/kg LUNGS, THORAX, OR RESPIRATION: CYANOSIS Journal of Toxicology, Clinical Toxicology. Vol. 19, Pg. 1061, 1982/1983. oral-child TDLo 37500 ug/kg GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN LUNGS, THORAX, OR RESPIRATION: CYANOSIS Pediatric Emergency Care. Vol. 13, Pg. 127, 1997. oral-guinea pig LD50 300 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991. oral-human TDLo 18000 mg/kg/15Y KIDNEY, URETER, AND BLADDER: OTHER CHANGES MUSCULOSKELETAL: JOINTS British Medical Journal. Vol. 1, Pg. 78, 1978. unreported-mammal (species unspecified) LD50 1400 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 23, 1978. oral-man TDLo 36 mg/kg BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN Human Toxicology. Vol. 2, Pg. 507, 1983. intraperitoneal-mouse LD50 313 mg/kg Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 336, 1952. intravenous-mouse LD50 225 mg/kg Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 336, 1952. oral-mouse LD50 250 mg/kg American Review of Tuberculosis. Vol. 60, Pg. 62, 1949. intraperitoneal-rat LD50 196 mg/kg PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 183, Pg. 36, 1970. oral-rat LD50 1000 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 250 mg/kg American Review of Tuberculosis. Vol. 60, Pg. 62, 1949. skin-rabbit LD50 > 4000 mg/kg Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | indirect food additives: adhesives and components of coatings | ||
| Recommendation for 4-aminophenyl sulfone usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for 4-aminophenyl sulfone flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a 9th list of substances for food contact materials View page or View pdf | |
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA Substance Registry Services (TSCA): | 80-08-0 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 2955 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| 4-(4-aminophenyl)sulfonylaniline | |
| Chemidplus: | 0000080080 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | BY8925000 for cas# 80-08-0 |
References:
| 4-(4-aminophenyl)sulfonylaniline | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 80-08-0 |
| Pubchem (cid): | 2955 |
| Pubchem (sid): | 134971843 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C07666 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2921.42.7500 |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| 4-(4- | aminophenyl)sulfonylaniline |
| avlosulfone | |
| benzenamine, 4,4'-sulfonylbis- | |
| dapsone | |
| 4,4'- | diaminodiphenyl sulphone |
| 4,4'- | sulfonylbisbenzenamine |
| sumicure S |