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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 344.30 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 293.00 °F. TCC ( 145.20 °C. ) (est)
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| logP (o/w): | 1.350 (est) |
| Soluble in: |
| | water, 5708 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-rat LD50 2974 mg/kg Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 243, Pg. 609, 1956.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for isovanillic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for isovanillic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| p- | anisic acid, 3-hydroxy- | | | benzoic acid, 3-hydroxy-4-methoxy- | | 3- | hydroxy-4-methoxy benzoic acid | | 3- | hydroxy-4-methoxybenzoic acid | | 3- | hydroxy-4-methoxybenzoicacid | | 3- | hydroxy-p-anisic acid | | 3- | hydroxyanisic acid |
Articles:
| PubMed: | Studies on the Biotransformation of Veratric Acid, a Human Metabolite of Mebeverine, by Using the Incubated Hen's Egg. |
| PubMed: | [Chemical constituents from the roots of Ilex pubescens]. |
| PubMed: | Antifungal activity of compounds extracted from Cortex Pseudolaricis against Colletotrichum gloeosporioides. |
| PubMed: | Molecular markers of biomass burning in arctic aerosols. |
| PubMed: | [Study on chemical composition of ethylacetate fraction from Polygonum amplexicaule var. sinense]. |
| PubMed: | [Chemical constituents of Psammosilene tunicoides and bacteriostatic activity]. |
| PubMed: | [Non-anthraquinones constituents from the roots of Knoxia valerianoides]. |
| PubMed: | In vitro and in vivo metabolism of verproside in rats. |
| PubMed: | [Chemical constituents from Gueldenstaedtia stenophylla]. |
| PubMed: | [Study on the chemical constituents of Phryma leptostachya]. |
| PubMed: | Chemical constituents of Cichorium intybus and their inhibitory effects against urease and alpha-chymotrypsin enzymes. |
| PubMed: | Structure elucidation of two new unusual monoterpene glycosides from Euphorbia decipiens, by 1D and 2D NMR experiments. |
| PubMed: | Amides from the stem of Capsicum annuum. |
| PubMed: | [Studies on the chemical constituents from the antithrombus activity extract of Radix Aerio Fici Microcarpae]. |
| PubMed: | Photoenhanced degradation of veratraldehyde upon the heterogeneous ozone reactions. |
| PubMed: | [Chemical constituents from Aeschynanthus longicaullis]. |
| PubMed: | [Isolation and identification of chemical constituents from peels of Citrus changshan-huyou Y.B. Chang]. |
| PubMed: | Simultaneous analysis of catechol-O-methyl transferase activity, S-adenosylhomocysteine and adenosine. |
| PubMed: | Limazepines A-F, pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp. |
| PubMed: | [Chemical constituents in the leave of Rhizophora stylosa L and their biological activities]. |
| PubMed: | Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae). |
| PubMed: | Reactivity of hydroxybenzoic acids in the hydrogen-isotope exchange reaction. |
| PubMed: | [Studies on chemical constituents in roots of Rumex dentatus]. |
| PubMed: | Isolation and characterization of Streptomyces sp. NL15-2K capable of degrading lignin-related aromatic compounds. |
| PubMed: | Metabolism of isovanillate, vanillate, and veratrate by Comamonas testosteroni strain BR6020. |
| PubMed: | Determination of active ingredients of Ilex Purpurea Hassk and its medicinal preparations by capillary electrophoresis with electrochemical detection. |
| PubMed: | Determination of hydrogen peroxide scavenging activity of cinnamic and benzoic acids employing a highly sensitive peroxyoxalate chemiluminescence-based assay: structure-activity relationships. |
| PubMed: | Enzymatic oxidation of vanillin, isovanillin and protocatechuic aldehyde with freshly prepared Guinea pig liver slices. |
| PubMed: | Metabolism of isovanillin by aldehyde oxidase, xanthine oxidase, aldehyde dehydrogenase and liver slices. |
| PubMed: | (R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy. |
| PubMed: | Tyrosinase inhibitor from black rice bran. |
| PubMed: | First total synthesis of the neuronal cell protecting carbazole alkaloid carbazomadurin A by sequential transition metal-catalyzed reactions. |
| PubMed: | [Studies on chemical constituents of Stelmatocrypton khasianum (Benth.) H. Bail]. |
| PubMed: | New antimicrobial mono- and sesquiterpenes from Soroseris hookeriana subsp. erysimoides. |
| PubMed: | On the metabolism of the amphetamine-derived antispasmodic drug mebeverine: gas chromatography-mass spectrometry studies on rat liver microsomes and on human urine. |
| PubMed: | Identification of a phenolic 3-O-methyltransferase in the lignin-degrading fungus Phanerochaete chrysosporium. |
| PubMed: | Comparison of the Efficacies of Chloromethane, Methionine, and S-Adenosylmethionine as Methyl Precursors in the Biosynthesis of Veratryl Alcohol and Related Compounds in Phanerochaete chrysosporium. |
| PubMed: | Antibacterial activity of the phenolic acids fractions of Scrophularia frutescens and Scrophularia sambucifolia. |
| PubMed: | Application of a Sex Pheromone, Pheromone Analogs, and Verticillium lecanii for Management of Heterodera glycines. |
| PubMed: | Validation of assay of catechol-O-methyltransferase activity in human erythrocytes. |
| PubMed: | Improved assay of reaction products to quantitate catechol-O-methyltransferase activity by high-performance liquid chromatography with electrochemical detection. |
| PubMed: | O-demethylation by the homoacetogenic anaerobe Holophaga foetida studied by a new photometric methylation assay using electrochemically produced cob(I)alamin. |
| PubMed: | The metabolism of mebeverine in man: identification of urinary metabolites by gas chromatography/mass spectrometry. |
| PubMed: | New aspects of co-regulation of decarboxylation and demethylation activities in Nocardia. |
| PubMed: | Host plant utilization and iridoid glycoside sequestration byEuphydryas anicia (Lepidoptera: Nymphalidae). |
| PubMed: | Substrate-induction of veratric acid O-demethylase in Nocardia sp. |
| PubMed: | Aerobic and Anaerobic Catabolism of Vanillic Acid and Some Other Methoxy-Aromatic Compounds by Pseudomonas sp. Strain PN-1. |
| PubMed: | Identification of phenolic acids in human urine by ion monitoring. |
| PubMed: | Regional distribution of methionine adenosyltransferase in rat brain as measured by a rapid radiochemical method. |
| PubMed: | Studies in vitro on the involvement of O-sulphate esters in the formation of O-methylated 3,4-dihydroxybenzoic acid by rat liver. |
| PubMed: | [Fluorimetric assay of 3-o-methyldopamine and 4-0-methyldopamine in rat urine and o-methylation of dopamine]. |
| PubMed: | [O-Methylation of epinephrine, 3,4-dihydroxybenzoic acid and 6,7-dihydroxycoumarin in yeasts (author's transl)]. |
| PubMed: | The metabolism of vanillin and isovanillin in the rat. |
| PubMed: | The estimation of 3,4-dihydroxyphenylacetic acid, homovanillic acid and homo-isovanillic acid in nervous tissue by gas-liquid chromatography and electron capture detection. |
| PubMed: | Degradation of methoxylated benzoic acids by a Nocardia from a lignin-rich environment: significance to lignin degradation and effect of chloro substituents. |
| PubMed: | [4-O-Methylated catecholamines: 3-hydroxy, 4-methoxyphenylacetic acid (homo-isovanillic acid, iso-HVA) in biological media: urine, cerebrospinal fluid, and brain tissue]. |
| PubMed: | The metabolites of isovanillic acid in man, with special reference to the formation of 3,4-dimethoxybenzoic acid. |
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