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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 114.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 308.00 to 309.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000384 mmHg @ 25.00 °C. (est) |
| Flash Point: | 248.00 °F. TCC ( 119.90 °C. ) (est)
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| logP (o/w): | 0.970 |
| Soluble in: |
| | alcohol | | | water, 1.102e+004 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-rat LD50 1276 mg/kg Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 243, Pg. 609, 1956.
intravenous-dog LDLo 1470 mg/kg Annales Pharmaceutiques Francaises. Vol. 14, Pg. 456, 1956.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for isovanillin usage levels up to: | | | not for fragrance use.
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| Recommendation for isovanillin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| p- | anisaldehyde, 3-hydroxy- | | 5- | formyl guaiacol | | 5- | formylguaiacol | | 3- | hydroxy-4-methoxybenzaldehyde | | 3- | hydroxy-p-anisaldehyde | | 3- | hydroxy-para-anisaldehyde |
Articles:
| Google Patents: | Process for the preparation of isovanillin |
| PubMed: | [New facts about the molecular background of isovanilline-type sweeteners]. |
| PubMed: | Phenolic composition of vinegars over an accelerated aging process using different wood species (acacia, cherry, chestnut, and oak): effect of wood toasting. |
| PubMed: | Isovanillin derived N-(un)substituted hydroxylamines possessing an ortho-allylic group: valuable precursors to bioactive N-heterocycles. |
| PubMed: | Solubilization in mixed micelles studied by molecular dynamics simulations and COSMOmic. |
| PubMed: | Three new ursane-type triterpenoids from the stems of Saprosma merrillii. |
| PubMed: | Molecular dynamics simulation of SDS and CTAB micellization and prediction of partition equilibria with COSMOmic. |
| PubMed: | [Phenolic compounds from Jatropha curcas]. |
| PubMed: | Synthesis and biological evaluation of combretastatin A-4 and three combretastatin-based hybrids. |
| PubMed: | Pd(II)-mediated cyclization of o-allylbenzaldehydes in water: a novel synthesis of isocoumarins. |
| PubMed: | [Antioxidant constituents from Smilax riparia]. |
| PubMed: | Vanillin and isovanillin: comparative vibrational spectroscopic studies, conformational stability and NLO properties by density functional theory calculations. |
| PubMed: | [Study on the chemical constituents from Fructus Toosendan (III)]. |
| PubMed: | Approaches to Iodinated Derivatives of Vanillin and Isovanillin. |
| PubMed: | Antioxidant phenolic compounds of cassava (Manihot esculenta) from Hainan. |
| PubMed: | 4',5'-Dichloro-2',7'-dimethoxy-5(6)-carboxyfluorescein (JOE): synthesis and spectral properties of oligonucleotide conjugates. |
| PubMed: | Novel 5, 6-Dihydropyrrolo[2,1-a]isoquinolines as Scaffolds for Synthesis of Lamellarin Analogues. |
| PubMed: | Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans. |
| PubMed: | Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. |
| PubMed: | Vanilloid derivatives as tyrosinase inhibitors driven by virtual screening-based QSAR models. |
| PubMed: | [Chemical constituents of rhizomes of Zingiber officinale]. |
| PubMed: | Transport and metabolism of the antitumour drug candidate 2'-benzoyloxycinnamaldehyde in Caco-2 cells. |
| PubMed: | [Chemical constituents from herb of Solanum lyratum]. |
| PubMed: | [Studies on chemical constituents in fruit of Alpinia oxyphylla]. |
| PubMed: | [Studies on chemical constituents of roots of Linum usitatissimum]. |
| PubMed: | [Analysis of chemical constituents of the volatile oil from flowers of Oyster Rhoeo by GC/MS]. |
| PubMed: | Allelochemicals and activities in a replanted Chinese fir (Cunninghamia lanceolata (Lamb.) Hook) tree ecosystem. |
| PubMed: | Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation. |
| PubMed: | [Chemical constituents from root barks of Periploca sepium]. |
| PubMed: | Synthesis of santiagonamine. |
| PubMed: | Stereocontrolled synthesis of (-)-galanthamine. |
| PubMed: | Contribution of aldehyde oxidizing enzymes on the metabolism of 3,4-dimethoxy-2-phenylethylamine to 3,4-dimethoxyphenylacetic acid by guinea pig liver slices. |
| PubMed: | Phenylacetaldehyde oxidation by freshly prepared and cryopreserved guinea pig liver slices: the role of aldehyde oxidase. |
| PubMed: | Metabolism of homovanillamine to homovanillic acid in guinea pig liver slices. |
| PubMed: | Biotransformation of benzaldehyde-type and acetophenone-type derivatives by Pharbitis nil hairy roots. |
| PubMed: | Synthesis of the beta-hydroxydopa-gamma-hydroxy-delta-sulfinylnorvaline component of ustiloxins A and B. |
| PubMed: | Enzymatic oxidation of vanillin, isovanillin and protocatechuic aldehyde with freshly prepared Guinea pig liver slices. |
| PubMed: | Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety. |
| PubMed: | Metabolism of 2-phenylethylamine to phenylacetic acid, via the intermediate phenylacetaldehyde, by freshly prepared and cryopreserved guinea pig liver slices. |
| PubMed: | Metabolism of isovanillin by aldehyde oxidase, xanthine oxidase, aldehyde dehydrogenase and liver slices. |
| PubMed: | Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin. |
| PubMed: | Contribution of aldehyde oxidase, xanthine oxidase, and aldehyde dehydrogenase on the oxidation of aromatic aldehydes. |
| PubMed: | A benzenoid from the stem of Acanthopanax senticosus. |
| PubMed: | Metabolism of 2-phenylethylamine and phenylacetaldehyde by precision-cut guinea pig fresh liver slices. |
| PubMed: | Xanthine oxidase-catalyzed metabolism of 2-nitrofluorene, a carcinogenic air pollutant, in rat skin. |
| PubMed: | Antioxidant and free-radical scavenging activity of constituents of the leaves of Tachigalia paniculata. |
| PubMed: | [Studies on chemical constituents of Stelmatocrypton khasianum (Benth.) H. Bail]. |
| PubMed: | Antineoplastic agents 463. Synthesis of combretastatin A-3 diphosphate prodrugs. |
| PubMed: | Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey: in vitro/in vivo correlation and the role of aldehyde oxidase. |
| PubMed: | Chemical constituents from Asparagus dumosus. |
| PubMed: | Thalprzewalskiinone, a new oxobenzylisoquinoline alkaloid from thalictrum przewalskii |
| PubMed: | Preclinical evaluation of 5-iodo-2-pyrimidinone-2'-deoxyribose as a prodrug for 5-iodo-2'-deoxyuridine-mediated radiosensitization in mouse and human tissues. |
| PubMed: | New p-quinonoid aporphine alkaloids and antiplatelet aggregation constituents of Hernandia sonora. |
| PubMed: | Role of aldehyde oxidase in the in vitro conversion of famciclovir to penciclovir in human liver. |
| PubMed: | A chemical model of catechol-O-methyltransferase. Methylation of 3,4-dihydroxybenzaldehyde in aqueous solution. |
| PubMed: | 3,3',5'-Tri-O-methylpiceatannol and 4,3',5'-tri-O-methylpiceatannol: improvements over piceatannol in bioactivity. |
| PubMed: | Synthesis and identification of the major metabolites of prazosin formed in dog and rat. |
| PubMed: | The metabolism of vanillin and isovanillin in the rat. |
| PubMed: | [Chromatographic separation and identification of 3-hydroxy,4-methoxymandelic (iso-VMa) and 4-hydroxy,3-methoxymandelic (VMA) acids in the form of their periodic oxidation derivatives: isovanillin and vanillin. Presence of 3-hydroxy,4-methoxymandelic acid in human urine]. |
| PubMed: | [Choleretic activity of isovanillin and ethylisovanillin in dogs]. |
| PubMed: | Azlactones and phenylacetic acids derived from the 2-nitro-derivatives of vanillin, isovanillin, and veratraldehyde. |
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