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Category: herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.32200 @ 25.00 °C.
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| Boiling Point: | 213.00 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.200000 mmHg @ 20.00 °C. (est) |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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| logP (o/w): | -0.760 (est) |
| Soluble in: |
| | water, 1.00E+06 mg/L @ 20 °C (exp) | | | water, 3.06e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-bird - wild LD50 23700 ug/kg Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
oral-mammal (species unspecified) LD50 82 mg/kg BEHAVIORAL: GENERAL ANESTHETIC
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE Annals of Applied Biology. Vol. 113, Pg. 307, 1988.
intraperitoneal-mouse LD50 73 mg/kg Journal of Medicinal Chemistry. Vol. 18, Pg. 116, 1975.
oral-mouse LD50 160 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS AMA Archives of Industrial Health. Vol. 14, Pg. 250, 1956.
oral-rat LD50 26 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) International Pest Control. Vol. 24, Pg. 20, 1982.
intraperitoneal-rat LDLo 10 mg/kg National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 9, 1953.
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| Dermal Toxicity: |
skin-rabbit LD50 800 uL/kg SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
BEHAVIORAL: ATAXIA
BEHAVIORAL: TREMOR National Technical Information Service. Vol. OTS0543607
skin-rat LD50 1057 mg/kg BEHAVIORAL: TREMOR
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
BEHAVIORAL: ATAXIA National Technical Information Service. Vol. OTS0543607
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| Inhalation Toxicity: |
inhalation-mouse LC50 > 90 ppm/4H GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE AMA Archives of Industrial Health. Vol. 14, Pg. 250, 1956.
inhalation-rat LCLo 125 ppm/4H Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 343, 1949.
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Safety in Use Information:
| Category: | herbicides / pesticides |
| Recommendation for 3-chloro-1,2-propane diol usage levels up to: | | | not for fragrance use.
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| Recommendation for 3-chloro-1,2-propane diol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Report of ESCO WG on non-plastic Food Contact Materials View page or View pdf |
Analysis of occurrence of 3-monochloropropane-1,2-diol (3-MCPD) in food in Europe in the years 2009-2011 and preliminary exposure assessment View page or View pdf |
Development and validation of analytical methods for the analysis of 3-MCPD (both in free and ester form) and glycidyl esters in various food matrices and performance of an ad-hoc survey on specific food groups in support to a scientific opinion on comprehensive risk assessment on the presence of 3-MCPD and glycidyl esters in food View page or View pdf |
Risks for human health related to the presence of 3- and 2-monochloropropanediol (MCPD), and their fatty acid esters, and glycidyl fatty acid esters in food View page or View pdf |
Update of the risk assessment on 3-monochloropropane diol and its fatty acid esters View page or View pdf |
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 96-24-2 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 7290 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | 3-chloropropane-1,2-diol |
| Chemidplus: | 0000096242 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | TY4025000 for cas# 96-24-2 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1- | chloro-1-deoxyglycerol | | 3- | chloro-1,2-dihydroxypropane | | (±)-3- | chloro-1,2-propanediol | | 3- | chloro-1,2-propanediol | | 3- | chloro-1,2-propylene glycol | | 1- | chloro-2,3-dihydroxypropane | | 1- | chloro-2,3-propanediol | | a- | chlorohydrin | | a-mono | chlorohydrin | | a- | chlorohydrine | | 3- | chloropropane-1,2-diol | | 3-mono | chloropropane-1,2-diol | | 1- | chloropropane-2,3-diol | | 3- | chloropropylene glycol | | 3- | chlorpropan-1,2-diol | | (±)-2,3- | dihydroxychloropropane | | 2,3- | dihydroxypropyl chloride | | | glycerin a-monochlorhydrin | | | glycerin epichlorohydrin | | | glycerine a-monochlorohydrin | | | glycerol 3-chlorohydrin | | | glycerol a-monochlorohydrin | | | glycerol a-monochlorohydrin [UN2689] [Keep away from food] | | | glycerol chlorohydrin | | a- | glycerol chlorohydrin | | | glyceryl a-chlorohydrin | | | glyceryl-a-chlorohydrin | | 1,2- | propanediol, 3-chloro- |
Articles:
| PubMed: | A novel approach of periodate oxidation coupled with HPLC-FLD for the quantitative determination of 3-chloro-1,2-propanediol in water and vegetable oil. |
| PubMed: | Metabonomic analysis of urine from rats after low-dose exposure to 3-chloro-1,2-propanediol using UPLC-MS. |
| PubMed: | A new, direct analytical method using LC-MS/MS for fatty acid esters of 3-chloro-1,2-propanediol (3-MCPD esters) in edible oils. |
| PubMed: | Absorption and metabolism of the food contaminant 3-chloro-1,2-propanediol (3-MCPD) and its fatty acid esters by human intestinal Caco-2 cells. |
| PubMed: | Migration studies of 3-chloro-1,2-propanediol (3-MCPD) in polyethylene extrusion-coated paperboard food packaging. |
| PubMed: | Carcinogenicity study of 3-monochloropropane-1, 2-diol (3-MCPD) administered by drinking water to B6C3F1 mice showed no carcinogenic potential. |
| PubMed: | Novel biomarkers of 3-chloro-1,2-propanediol exposure by ultra performance liquid chromatography/mass spectrometry based metabonomic analysis of rat urine. |
| PubMed: | Mixed sorbent phases for thick film open tubular traps. |
| PubMed: | Hydrolysis and H2O2-assisted UV photolysis of 3-chloro-1,2-propanediol. |
| PubMed: | Rational design of solid catalysts for the selective use of glycerol as a natural organic building block. |
| PubMed: | Occurrence of 3-MCPD fatty acid esters in human breast milk. |
| PubMed: | Esters of 3-chloro-1,2-propanediol (3-MCPD) in vegetable oils: significance in the formation of 3-MCPD. |
| PubMed: | A reinvestigation of the synthesis of arsonolipids (2,3-diacyloxypropylarsonic acids). |
| PubMed: | Evaluation of certain food additives and contaminants. |
| PubMed: | The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation. |
| PubMed: | [Study on elimination of 3-chloro-1,2-propanediol in hydrolyzed vegetable protein by capillary electrophoresis with electrochemical detection]. |
| PubMed: | Removal of 1,3-dichloro2-propanol and 3-chloro1,2-propanediol by the whole cell system of pseudomonas putida DSM 437. |
| PubMed: | Determination of rate constants and activation energy of 3-chloro-1,2-propanediol hydrolysis by capillary electrophoresis with electrochemical detection. |
| PubMed: | Biodegradation of 3-chloro-1,2-propanediol with Saccharomyces cerevisiae. |
| PubMed: | Model studies on the formation of monochloropropanediols in the presence of lipase. |
| PubMed: | [Study on the toxicological effect of chloropropanols on rats]. |
| PubMed: | Evaluation of certain food additives and contaminants. |
| PubMed: | Determination of 3-chloro-1,2-propanediol in foods and food ingredients by gas chromatography with mass spectrometric detection: collaborative study. |
| PubMed: | Conformational features of reduced and disulfide intact forms of hen egg white lysozyme in aqueous solution in presence of 3-chloro-1, 2-propanediol and dioxane: implications for protein folding intermediates. |
| PubMed: | Determination of halogenated mono-alcohols and diols in water by gas chromatography with electron-capture detection. |
| PubMed: | Analytical methods for the determination of 3-chloro-1,2-propandiol and 2-chloro-1,3-propandiol in hydrolysed vegetable protein, seasonings and food products using gas chromatography/ion trap tandem mass spectrometry. |
| PubMed: | Biochemical characterization of a haloalcohol dehalogenase from Arthrobacter erithii H10a. |
| PubMed: | The vicinal chloroalcohols 1,3-dichloro-2-propanol (DC2P), 3-chloro-1,2-propanediol (3CPD) and 2-chloro-1,3-propanediol (2CPD) are not genotoxic in vivo in the wing spot test of Drosophila melanogaster. |
| PubMed: | Antifertility potential of ornidazole analogues in rats. |
| PubMed: | Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo. |
| PubMed: | Purification and Characterization of Two Epoxide Hydrolases from Corynebacterium sp. Strain N-1074. |
| PubMed: | Utilization of a short-term male reproductive toxicity study design to examine effects of alpha-chlorohydrin (3-chloro-1,2-propanediol). |
| PubMed: | Production of (R)-3-Chloro-1,2-Propanediol from Prochiral 1,3-Dichloro-2-Propanol by Corynebacterium sp. Strain N-1074. |
| PubMed: | Resolution and some properties of enzymes involved in enantioselective transformation of 1,3-dichloro-2-propanol to (R)-3-chloro-1,2-propanediol by Corynebacterium sp. strain N-1074. |
| PubMed: | Identification and quantitative analysis of urinary metabolites of dichloropropanols in rats. |
| PubMed: | Purification and characterization of haloalcohol dehalogenase from Arthrobacter sp. strain AD2. |
| PubMed: | Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food. |
| PubMed: | NTP Toxicology and Carcinogenesis Studies of Glycidol (CAS No. 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies). |
| PubMed: | Genotoxicity, metabolism and blood kinetics of epichlorohydrin in mice. |
| PubMed: | The comparative effects of 1,2-dibromo-3-chloropropane (DBCP) and its metabolites, 3-chloro-1,2-propaneoxide (epichlorohydrin), 3-chloro-1,2-propanediol (alphachlorohydrin), and oxalic acid, on the urogenital system of male rats. |
| PubMed: | Mutagenicity of glycerol chlorohydrines and of their esters with higher fatty acids present in protein hydrolysates. |
| PubMed: | Measurement of Metabolites Associated with Nonaqueously Isolated Starch Granules from Immature Zea mays L. Endosperm. |
| PubMed: | A Nonaqueous Procedure for Isolating Starch Granules with Associated Metabolites from Maize (Zea mays L.) Endosperm. |
| PubMed: | Antifertility activity of alpha-chlorohydrin (3-chloro-1, 2 propanediol, U-5897) on the female rats. |
| PubMed: | Effect of alpha-chlorohydrin on the male reproductive organs of the Indian langur. |
| PubMed: | DNA synthesis in HeLa cell nuclei isolated in a non-aqueous medium. |
| PubMed: | Chemical sterilization: effects of a single high dose of 3-chloro-1,2-propanediol on the testes and epididymides of dog. |
| PubMed: | Biochemical changes in the female genital tract of the hedgehog following 3-chloro-1,2-propanediol administration. |
| PubMed: | Observations of the effects of 3-chloro-1,2-propanediol on the female reproductive tract and pituitary gonadotrophs of the gerbil (Meriones hurrianae). |
| PubMed: | Studies on the male anti-fertility drug 3-chloro-1,2-propanediol. |
| PubMed: | [Effect of 3-chloro-1,2-propanediol on the tests and seminal vesicles in rats. Histochemical study]. |
| PubMed: | New developments in contraceptive agents. |
| PubMed: | Bulk isolation in nonaqueous media of nuclei from lyophilized cells. |
| PubMed: | Antifertility activity of 3-chloro-1, 2-propanediol (U-5897) on male rats. |
| PubMed: | Nature and site of action of 3-chloro-1,2-propanediol--an oral antifertility agent for the male. |
| PubMed: | Possible mechanism of posttesticular antifertility action of 3-chloro-1,2-propanediol. |
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