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Category: herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 159.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 347.20 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 4.400000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 375.00 °F. TCC ( 190.70 °C. ) (est)
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| logP (o/w): | -0.860 |
| Soluble in: |
| | water, 2.80E+05 mg/L @ 25 °C (exp) | | | water, 8.649e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| 3-Amino-1,2,4-triazole
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| Charkit Chemical |
| AMINO-1,2,4-TRIAZOLE, 3-
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| Glentham Life Sciences |
| 3-Amino-1,2,4-triazole
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 3-Amino-1,2,4-triazole ≥95%
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| Sigma-Aldrich |
| For experimental / research use only. |
| Amitrole PESTANAL®, analytical standard
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| TCI AMERICA |
| For experimental / research use only. |
| 3-Amino-1,2,4-triazole >98.0%(GC)(T)
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Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 200 mg/kg National Technical Information Service. Vol. AD277-689
intravenous-mouse LD50 > 5000 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 597, 1977.
oral-mouse LD50 14700 mg/kg Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 33, 1966.
oral-quail LD50 > 316 mg/kg Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.
oral-rat LD50 1100 mg/kg Residue Reviews. Vol. 10, Pg. 97, 1965.
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| Dermal Toxicity: |
skin-rat LD50 > 10000 mg/kg World Review of Pest Control. Vol. 9, Pg. 119, 1970.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | herbicides / pesticides |
| Recommendation for amitrole usage levels up to: | | | not for fragrance use.
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| Recommendation for amitrole flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Conclusion on the peer review of the pesticide risk assessment of the active substance amitrole View page or View pdf |
Protocol for the evaluation of data concerning the necessity of the application of herbicide active substances to control a serious danger to plant health which cannot be contained by other available means, including non-chemical methods View page or View pdf |
| EPI System: | View |
| NIOSH International Chemical Safety Cards: | search |
| NIOSH Pocket Guide: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 61-82-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 1639 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| | 1H-1,2,4-triazol-5-amine |
| Chemidplus: | 0000061825 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 61-82-5 |
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| KEGG (GenomeNet): | C11261 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2933.99.8500 |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations: •amizine is trade name for mixture of amitrole & simazine and fenamine refers to combination of amitrole, fenac & atrazine.
•kleer-lot (mixture of amitrole & linuron) .
•amino triazole weedkiller 90 is dry soluble powder formulation containing 90% active ingredient. cytrol amitrole-t liquid weedkiller is water soluble formulation containing 2 lbs amino triazole plus 19% ammonium thiocyanategal.
•pure, technical grades
•amizine is a mixture of amitrole & princep; diurol 5030 is amitrole with diuron; fenamine is amitrole with fenac & atrazine; fenavar liq is amitrole with bromacil & ammonium thiocyanate; simazol is a mixture of simazine & amitrole; ustilan nk, ustilan t, ustinex are amitrole in combination with different herbicides. farmco amizine-aa contains 320 gl amitrole, 320 gl atrazine; farmco amitrol-t is 250 gl amitrole, 220 gl ammonium thiocyanate. mixtures
•soluble powder, soluble concentrate, suspension concentrate, water soluble, wettable powder, or flakes.
•discontinued trade names: amino triazole weed killer-90; amizine; at-90; at-liquid; cytrol amitrole-t; diurol; farmaco; herbixol; herbizole; kleer-lot; phoscatrol; uracom; ustilan gw; weedazol t
•the only available formulation for amitrole is a 90% wettable powder. the registrant voluntarily cancelled the 21.6% emulsifiable concentrate formulation in 1996.
•trade name: amitrole
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 3- | amino-1,2,4-triazole | | 2- | amino-1,3,4-triazole | | 3- | amino-1H-1,2,4-triazole | | 2- | aminotriazole | | | amitrol | | | amizol D | | | cytrole | | | diurol 5030 | | | emisol 50 | | | fenavar | | | herbidal total | | | herbizole | | | kleer-lot | | | orga-414 | | | radoxone TL | | | ramizol | | | simazol | | 1H-1,2,4- | triazol-3-ylamine | | 1H-1,2,4- | triazol-5-amine | | | vorox AA | | | weedar ADS | | | weedazin | | | weedazol | | | weedazol T | | | weedoclor | | | x-all liquid
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Articles:
| PubMed: | Rapid detection of pesticides not amenable to multi-residue methods by flow injection-tandem mass spectrometry. |
| PubMed: | Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice. |
| PubMed: | β-ODAP accumulation could be related to low levels of superoxide anion and hydrogen peroxide in Lathyrus sativus L. |
| PubMed: | Protective mechanism of quercetin and rutin using glutathione metabolism on HO-induced oxidative stress in HepG2 cells. |
| PubMed: | Determination of amitrole in environmental water samples with precolumn derivatization by high-performance liquid chromatography. |
| PubMed: | Oxidative alterations induced by D-aspartic acid in prepubertal rat testis in vitro: a mechanistic study. |
| PubMed: | [Effects of amitrole on thyroid hormone-associated gene transcription in FRTL-5 cells]. |
| PubMed: | Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. |
| PubMed: | Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus. |
| PubMed: | Acetylation of 5-amino-1H-[1,2,4]triazole revisited. |
| PubMed: | Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status. |
| PubMed: | Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants. |
| PubMed: | Pentachlorophenol-induced oxidative DNA damage in mouse liver and protective effect of antioxidants. |
| PubMed: | Effects of aminotriazole on ethanol, water, and food intake and on brain catalase in UChA and UChB rats. |
| PubMed: | A role for thyroid hormones in cold-induced elevation of blood pressure and cardiac hypertrophy. |
| PubMed: | Production of β-damascenone precursors in cell cultures of Vitis labruscana cv Concord grapes. |
| PubMed: | Effects of 3-amino-1,2,4-triazole on brain catalase in the mediation of ethanol consumption in mice. |
| PubMed: | Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum. |
| PubMed: | Response of the medullary thick ascending limb to hypothyroidism in the rat. |
| PubMed: | Kidney structure in hypothyroidism. |
| PubMed: | Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats. |
| PubMed: | Potential carcinogenicity of food additives and contaminants. |
| PubMed: | Absorption of herbicides by wheat as influenced by the phenoxy compound. |
| PubMed: | Insecticide inhibition of herbicide metabolism in leaf tissues. |
| PubMed: | Extraction of 3-amino-1,2,4-triazole (amitrole) and 2,6-dichloro-4-nitroaniline (DCNA) from soils. |
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