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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white to pale yellow powder (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 181.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 302.00 to 303.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 250.00 °F. TCC ( 120.90 °C. ) (est)
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| logP (o/w): | 1.610 |
| Soluble in: |
| | alcohol | | | ether | | | water, 1 part to 2100-2150 parts water | | | water, 500 mg/L @ 14C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 > 800 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 196, Pg. 478, 1976.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for veratric acid usage levels up to: | | | not for fragrance use.
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| Recommendation for veratric acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoic acid, 3,4-dimethoxy- | | 3,4- | dimethoxy-benzoic acid | | 3,4- | dimethoxybenzoic acid | | 3,4- | dimethoxybenzoicacid | | 3,4- | dimethyl protocatechuic acid | | 3,4- | dimethylprotocatechuic acid | | (±)-m- | methoxymandelic acid |
Articles:
| PubMed: | Veratric acid inhibits iNOS expression through the regulation of PI3K activation and histone acetylation in LPS-stimulated RAW264.7 cells. |
| PubMed: | Studies on the Biotransformation of Veratric Acid, a Human Metabolite of Mebeverine, by Using the Incubated Hen's Egg. |
| PubMed: | Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis. |
| PubMed: | Inhibitory effect of aqueous extracts from Miracle Fruit leaves on mutation and oxidative damage. |
| PubMed: | Protective effect of veratric acid on lipopolysaccharide-induced acute lung injury in mice. |
| PubMed: | Distribution of Two bioactive compounds in flowers of Trollius chinensis. |
| PubMed: | Crabgrass (Digitaria sanguinalis) allelochemicals that interfere with crop growth and the soil microbial community. |
| PubMed: | Antagonist effects of veratric acid against UVB-induced cell damages. |
| PubMed: | The regulatory effect of veratric acid on NO production in LPS-stimulated RAW264.7 macrophage cells. |
| PubMed: | Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli. |
| PubMed: | Investigation of the substrate range of CYP199A4: modification of the partition between hydroxylation and desaturation activities by substrate and protein engineering. |
| PubMed: | The wood rot ascomycete Xylaria polymorpha produces a novel GH78 glycoside hydrolase that exhibits α-L-rhamnosidase and feruloyl esterase activities and releases hydroxycinnamic acids from lignocelluloses. |
| PubMed: | Veratric acid ameliorates hyperlipidemia and oxidative stress in Wistar rats fed an atherogenic diet. |
| PubMed: | Effect of veratric acid on the cardiovascular risk of L-NAME-induced hypertensive rats. |
| PubMed: | Nonlinear changes in the activity of the oxygen-dependent demethylase system in Rhodococcus erythropolis cells in the presence of low and very low doses of formaldehyde. |
| PubMed: | Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats. |
| PubMed: | Synthesis of homoveratric acid-imprinted polymers and their evaluation as selective separation materials. |
| PubMed: | Photoenhanced degradation of veratraldehyde upon the heterogeneous ozone reactions. |
| PubMed: | Selective oxidative demethylation of veratric acid to vanillic acid by CYP199A4 from Rhodopseudomonas palustris HaA2. |
| PubMed: | [Spectroscopic investigation on the interaction of protocatechuic acid and veratric acid with biomacromolecules]. |
| PubMed: | Influence of very low doses of mediators on fungal laccase activity - nonlinearity beyond imagination. |
| PubMed: | Hansch analysis of veratric acid derivatives as antimicrobial agents. |
| PubMed: | Assessment of the genotoxicity of olive mill waste water (OMWW) with the Vicia faba micronucleus test. |
| PubMed: | Isolation and characterization of Streptomyces sp. NL15-2K capable of degrading lignin-related aromatic compounds. |
| PubMed: | Molecular cloning of streptomyces genes encoding vanillate demethylase. |
| PubMed: | Metabolism of isovanillate, vanillate, and veratrate by Comamonas testosteroni strain BR6020. |
| PubMed: | Investigative implications of the instability and metabolism of mebeverine. |
| PubMed: | Regulation of Laccase Gene Transcription in Trametes versicolor. |
| PubMed: | Involvement of lipid peroxidation in the degradation of a non-phenolic lignin model compound by manganese peroxidase of the litter-decomposing fungus Stropharia coronilla. |
| PubMed: | Production of laccase by immobilized cells of Agaricus sp.: induction effect of xylan and lignin derivatives. |
| PubMed: | Biotransformation of lignin polymers derived from beech wood pulping by Sporobolomyces roseus isolated from leafy material. |
| PubMed: | [Phenyl pyrazolones--novel oxidoreductase redox-mediators for degradation of xenobiotics]. |
| PubMed: | Acylated flavone C-glycosides from Trollius ledebouri. |
| PubMed: | Trollioside, a new compound from the flowers of Trollius chinensis. |
| PubMed: | Tyrosinase inhibitor from black rice bran. |
| PubMed: | Enzyme production by Mycena galopus mycelium in artificial media and in Picea sitchensis F1 horizon needle litter. |
| PubMed: | Mechanistic features of lignin peroxidase-catalyzed oxidation of substituted phenols and 1,2-dimethoxyarenes. |
| PubMed: | Relationship of demethylation processes to veratric acid concentration and cell density in cultures of Rhodococcus erythropolis. |
| PubMed: | [A study on chemical constituents in the herb of Mentha spicata]. |
| PubMed: | Lignin degradation in a compost environment by the deuteromycete Paecilomyces inflatus. |
| PubMed: | Induction of laccase activity in the edible straw mushroom, Volvariella volvacea. |
| PubMed: | Influence of aromatic compounds on biodegradation of [14C]-labeled xylan and mannan by the white-rot fungus Phlebia radiata. |
| PubMed: | Identification of mebeverine acid as the main circulating metabolite of mebeverine in man. |
| PubMed: | Kinetic model for phenolic compound oxidation by Fenton's reagent. |
| PubMed: | The antispasmodic drug mebeverine leads to positive amphetamine results by fluorescence polarization immunoassay (FPIA)--studies on the toxicological analysis of urine by FPIA and GC-MS. |
| PubMed: | Differential regulation of laccase gene expression in Pleurotus sajor-caju. |
| PubMed: | Demethylation of [14C]-labelled veratric acid and oxidation of methanol and formaldehyde by the white-rot fungus Phlebia radiata. |
| PubMed: | Multiple respiratory bursts as a response to veratrate stress in Rhodococcus erythropolis cells. |
| PubMed: | On the metabolism of the amphetamine-derived antispasmodic drug mebeverine: gas chromatography-mass spectrometry studies on rat liver microsomes and on human urine. |
| PubMed: | Relationships between demethylase activity, formaldehyde and oxygen during incubation of Rhodococcus erythropolis with veratrate. |
| PubMed: | Genetics of ferulic acid bioconversion to protocatechuic acid in plant-growth-promoting Pseudomonas putida WCS358. |
| PubMed: | Lack of bioavailability of mebeverine even after pretreatment with pyridostigmine. |
| PubMed: | Comparison of the Efficacies of Chloromethane, Methionine, and S-Adenosylmethionine as Methyl Precursors in the Biosynthesis of Veratryl Alcohol and Related Compounds in Phanerochaete chrysosporium. |
| PubMed: | Decoloration of azo dyes by three whiterot fungi: influence of carbon source. |
| PubMed: | Anisaldehyde and Veratraldehyde Acting as Redox Cycling Agents for H(2)O(2) Production by Pleurotus eryngii. |
| PubMed: | The metabolism of mebeverine in man: identification of urinary metabolites by gas chromatography/mass spectrometry. |
| PubMed: | Degradation of non-phenolic beta-o-4 lignin substructure model compounds by Acinetobacter sp. |
| PubMed: | Facile hydrolysis of mebeverine in vitro and in vivo: negligible circulating concentrations of the drug after oral administration. |
| PubMed: | Formation and Action of Lignin-Modifying Enzymes in Cultures of Phlebia radiata Supplemented with Veratric Acid. |
| PubMed: | Degradation of labelled lignins and veratrylglycerol-beta-guaiacyl ether by Acinetobacter sp. |
| PubMed: | Regulation of the production of hemicellulolytic and cellulolytic enzymes by a Streptomyces sp. growing on lignocellulose. |
| PubMed: | Metabolism of Lignin Model Compounds of the Arylglycerol-beta-Aryl Ether Type by Pseudomonas acidovorans D(3). |
| PubMed: | The action of mebeverine and metabolites on mammalian non-myelinated nerve fibres. |
| PubMed: | Antimicrobial properties of aromatic compounds of plant origin. |
| PubMed: | Variation of melatonin and serotonin content in rat pineal gland with sex and oestrous phase difference determined by high-performance liquid chromatography with fluorimetric detection. |
| PubMed: | Substrate-induction of veratric acid O-demethylase in Nocardia sp. |
| PubMed: | Aerobic and Anaerobic Catabolism of Vanillic Acid and Some Other Methoxy-Aromatic Compounds by Pseudomonas sp. Strain PN-1. |
| PubMed: | New compounds: Reissert compound studies XXXII: facile synthesis of 3-azapapaverine. |
| PubMed: | [O-Demethylation of benzoic acids in wheat seedlings]. |
| PubMed: | Degradation of methoxylated benzoic acids by a Nocardia from a lignin-rich environment: significance to lignin degradation and effect of chloro substituents. |
| PubMed: | A note on the synthesis of veratric acid. |
| PubMed: | Studies in detoxication; the metabolism of veratraldehyde and veratric acid in the rabbit. |
| PubMed: | Studies in detoxication: 14. The metabolism of veratraldehyde and veratric acid in the rabbit. |
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