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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 396.39 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 305.00 °F. TCC ( 151.50 °C. ) (est)
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| logP (o/w): | 2.001 (est) |
| Soluble in: |
| | water, 3040 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| 3,4,5-Trimethoxycinnamic acid 98%
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| BOC Sciences |
| For experimental / research use only. |
| 3,4,5-Trimethoxycinnamic acid >95%
Odor: characteristic Use: 3,4,5-Trimethoxycinnamic acid is found in the heartwoods of Cassia garrettiana, it has anti-stress effect, prolonging the sleep |
| Penta International |
| 3,4,5-TRIMETHOXY CINNAMIC ACID
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 3,4,5-Trimethoxycinnamic acid
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| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 3,4,5-Trimethoxycinnamic acid 97%
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| TCI AMERICA |
| For experimental / research use only. |
| 3,4,5-Trimethoxycinnamic Acid >98.0%(GC)(T)
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Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-bird - wild LD50 422 mg/kg Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for 3,4,5-trimethoxycinnamic acid (predominantly trans) usage levels up to: | | | not for fragrance use.
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| Recommendation for 3,4,5-trimethoxycinnamic acid (predominantly trans) flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cinnamic acid, 3,4,5-trimethoxy- | | 2- | propenoic acid, 3-(3,4,5-trimethoxyphenyl)- | | 2- | propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, (2E)- | | | sinapic acid methyl ether | | 3,4,5- | trimethoxy cinnamic acid | | (E)-3-(3,4,5- | trimethoxy-phenyl)-acrylic acid | | 3-(3,4,5- | trimethoxy-phenyl)-acrylic acid | | 3,4,5- | trimethoxycinnamic acid | | 3,4,5- | trimethoxycinnamicacid | | 3-(3,4,5- | trimethoxyphenyl)-2-propenoic acid | | (2E)-3-(3,4,5- | trimethoxyphenyl)acrylic acid | | (E)-3-(3,4,5- | trimethoxyphenyl)acrylic acid | | 3-(3,4,5- | trimethoxyphenyl)acrylic acid | | (2E)-3-(3,4,5- | trimethoxyphenyl)prop-2-enoic acid | | (E)-3-(3,4,5- | trimethoxyphenyl)prop-2-enoic acid |
Articles:
| PubMed: | 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice. |
| PubMed: | Synthesis and biological evaluation of piperlongumine derivatives as potent anti-inflammatory agents. |
| PubMed: | In vitro immunocompetence of two compounds isolated from Polygala tenuifolia and development of resistance against grass carp reovirus (GCRV) and Dactylogyrus intermedius in respective host. |
| PubMed: | 3,4,5-Trimethoxycinnamin acid ameliorates restraint stress-induced anxiety and depression. |
| PubMed: | 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. |
| PubMed: | Potential antiarrhythmic effect of methyl 3,4,5-trimethoxycinnamate, a bioactive substance from roots of polygalae radix: suppression of triggered activities in rabbit myocytes. |
| PubMed: | Synthesis and evaluation of a series of 3,4,5-trimethoxycinnamic acid derivatives as potential antinarcotic agents. |
| PubMed: | A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots and stems of Piper sarmentosum. |
| PubMed: | Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents. |
| PubMed: | Enantioselective sequential conjugate addition-allylation reactions: a concise total synthesis of (+)-podophyllotoxin. |
| PubMed: | BT-11 improves stress-induced memory impairments through increment of glucose utilization and total neural cell adhesion molecule levels in rat brains. |
| PubMed: | Antiplatelet activities of newly synthesized derivatives of piperlongumine. |
| PubMed: | Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). |
| PubMed: | Biosynthesis of podophyllotoxin in Linum album cell cultures. |
| PubMed: | Phenylpropanoid Metabolism in Suspension Cultures of Vanilla planifolia Andr. : III. Conversion of 4-Methoxycinnamic Acids into 4-Hydroxybenzoic Acids. |
| PubMed: | Aerobic and Anaerobic Catabolism of Vanillic Acid and Some Other Methoxy-Aromatic Compounds by Pseudomonas sp. Strain PN-1. |
| PubMed: | [Biliary excretion of choleretically active cinnamic acid derivatives in the rat]. |
| PubMed: | Bacterial degradation of 3,4,5-trimethoxycinnamic acid with production of methanol. |
| PubMed: | 3,4,5-trimethoxycinnamic acid and related compounds. II. Metabolism in the rat. |
| PubMed: | 3,4,5-trimethoxycinnamic acid and related compounds. I. Metabolism by the rat intestinal microflora. |
| PubMed: | Metabolism of sinapic acid and related compounds in the rat. |
| PubMed: | [Simple synthetic models of rescinnamine: basic esters and amides of 3,4,5-trimethoxycinnamic acid. Note II]. |
| PubMed: | [Simple synthetic models of rescinnamine: basic esters and amides of 3,4,5-trimethoxycinnamic acid. Note I]. |
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