Articles:
| None found yet. Try the PubMed Search. |
Notes:
Alpha-Hydroxyisobutyric acid is a metabolite of methyl tert-butyl ether (MTBE). MTBE may be obtained through environmental exposure. MTBE is rapidly eliminated from the body, mainly through expired air as the unchanged compound. MTBE is to some extent metabolised to t-butyl alcohol (TBA) and formaldehyde and oxidised to 2-methyl-1,2-propanediol and a-hydroxy isobuturic acid. Alpha-Hydroxyisobutyric acid has been used as an arial bactericide. [HMDB]
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| CAS Number: | 594-61-6 |  3D/inchi
|
| Other(deleted CASRN): | 27909-95-1 | |
| ECHA EINECS - REACH Pre-Reg: | 209-848-8 | |
| FDA UNII: | DMW250U2HF | |
| Beilstein Number: | 1744739 | |
| MDL: | MFCD00004459 | |
| XlogP3: | -0.40 (est) | |
| Molecular Weight: | 104.10536000 | |
| Formula: | C4 H8 O3 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 82.50 °C. @ 760.00 mm Hg |
| Boiling Point: | 212.00 °C. @ 760.00 mm Hg |
| logP (o/w): | -0.360 |
| Soluble in: | |
| water, 1e+006 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
fragrance |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| a-Hydroxyisobutyric acid 98% |
| Carbosynth |
| For experimental / research use only. |
| Hydroxyisobutyric acid |
| EMD Millipore |
| For experimental / research use only. |
| 2-Hydroxyisobutyric Acid |
| Penta International |
| 2-HYDROXYISOBUTYRIC ACID |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 2-Hydroxyisobutyric Acid |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| a-Hydroxyisobutyric acid 99% |
| TCI AMERICA |
| For experimental / research use only. |
| 2-Hydroxyisobutyric Acid >98.0%(T) |
| Universal Preserv-A-Chem Inc. |
| 2-HYDROXY ISOBUTYRIC ACID 99%
Odor: characteristic Use: Used as a paint and ink additive. For cosmetics it is used as a base, a thickening agent, a pigment wetting agent, a dispersant, a solvent and an emollient in skin and eye make-up and in lipstick. Thickening agent, skin conditioning agent and emollient in skin care products. Used as a lubricant for plastics. Procesing agent for rubber and it is also used as an oiling agent for textiles. |
| Universal Preserv-A-Chem Inc. |
| 2-HYDROXY ISOBUTYRIC ACID
Odor: characteristic Use: Used as a paint and ink additive. For Cosmetics it is used as a Base, a Thickening Agent, a Pigment Wetting Agent, a Dispersant, a Solvent and an Emollient in Skin and Eye Make-Up and in Lipstick. Thickening Agent, Skin Conditioning Agent and Emollient in Skin Care Products. Used as a Lubricant for Plastics. Procesing agent for rubber. Oiling agent for textiles. |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | cosmetic agents | ||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for 2-hydroxyisobutyric acid flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 594-61-6 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 11671 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 2-hydroxy-2-methylpropanoic acid | |
| Chemidplus: | 0000594616 |
References:
| 2-hydroxy-2-methylpropanoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 594-61-6 |
| Pubchem (cid): | 11671 |
| Pubchem (sid): | 134978460 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| UM BBD: | Search |
| HMDB (The Human Metabolome Database): | HMDB00729 |
| FooDB: | FDB022207 |
| Export Tariff Code: | 2918.19.9000 |
| ChemSpider: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| acetonic acid | |
| 2- | hydroxy-2-methyl-propanoic acid |
| 2- | hydroxy-2-methyl-propionic acid |
| 2- | hydroxy-2-methylpropanoic acid |
| 2- | hydroxy-2-methylpropanoicacid |
| 2- | hydroxy-2-methylpropionic acid |
| a- | hydroxy-a-methylpropanoic acid |
| alpha- | hydroxy-alpha-methylpropanoic acid |
| alpha- | hydroxy-alpha-methylpropionic acid |
| alpha- | hydroxy-isobutyric acid |
| .alpha.- | hydroxyisobutanoic acid |
| a- | hydroxyisobutanoic acid |
| alpha- | hydroxyisobutanoic acid |
| .alpha.- | hydroxyisobutyric acid |
| alpha- | hydroxyisobutyric acid |
| lactic acid, 2-methyl- | |
| 2- | methyl lactic acid |
| 2- | methyl-2-hydroxypropanoic acid |
| 2- | methyllactic acid |
| propanoic acid, 2-hydroxy-2-methyl- |