Articles:
o-trans-coumaric acid
Notes:
Occurs in many plants e.g. Melilotus officinalis (sweet clover)
Coumaric acid is a hydroxycinnamic acid, an organic compound that is a hydroxy derivative of cinnamic acid. There are three isomers, o-coumaric acid, m-coumaric acid, and p-coumaric acid, that differ by the position of the hydroxy substitution of the phenyl group. p-Coumaric acid is the most abundant isomer of the three in nature. (Wikipedia)
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 614-60-8 2-Hydroxycinnamic acid
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Chemical sources Association Inc Exchange of knowledge Need This Item for Flavor? You can contact the Chemical Sources Association. Events Links Product(s):
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Jiangyin Healthway International Trade Co., Ltd Independent Ingredients Supplier We provide custom synthesis and contract manufacturing from milligrams to metric tonnes. Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals. Email: Info Email: Sales Voice: 86-510-86023169 Fax: 86-510-86023170 Mobile 0086-13093133011 Services Biochemical Natural Food Colour New functional food ingredients Product(s): HLK093 2-Hydroxycinnamic acid Natural98%
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 03-49700 ORTHO-TRANS-COMARIC ACID
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): C0394 trans-o-Coumaric Acid >98.0%(GC)(T)
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| CAS Number: | 614-60-8 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 210-386-4 | |
| FDA UNII: | 23AU5FZB9C | |
| Nikkaji Web: | J55.415D | |
| Beilstein Number: | 1100900 | |
| MDL: | MFCD00004379 | |
| XlogP3: | 1.50 (est) | |
| Molecular Weight: | 164.16036000 | |
| Formula: | C9 H8 O3 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FEMA Number: | 4700 o-trans-coumaric acid |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 614-60-8 ; O-TRANS-COUMARIC ACID |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 348.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000019 mmHg @ 25.00 °C. (est) |
| Flash Point: | 353.00 °F. TCC ( 178.50 °C. ) (est) |
| logP (o/w): | 2.430 (est) |
| Soluble in: | |
| alcohol | |
| water, 2.709e+004 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| 2-Hydroxycinnamic acid |
| EMD Millipore |
| For experimental / research use only. |
| 2-Hydroxycinnamic Acid |
| ExtraSynthese |
| For experimental / research use only. |
| 2-Coumaric Acid (HPLC) ≥90% |
| Jiangyin Healthway |
| 2-Hydroxycinnamic acid Natural98% |
| New functional food ingredients |
| Penta International |
| ORTHO-TRANS-COMARIC ACID |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 2-Hydroxycinnamic acid, predominantly trans |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 2-Hydroxycinnamic acid, predominantly trans 97% |
| TCI AMERICA |
| For experimental / research use only. |
| trans-o-Coumaric Acid >98.0%(GC)(T) |
| Chemical Sources Association |
| Need This Item for Flavor/Food?: You can contact the CSA |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-mouse LD50 180 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02587 | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | antioxidants | ||
| Recommendation for (E)-ortho-coumaric acid usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 25 | |||
| Click here to view publication 25 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 20.00000 | 30.00000 | |
| beverages(nonalcoholic): | 10.00000 | 30.00000 | |
| beverages(alcoholic): | 10.00000 | 30.00000 | |
| breakfast cereal: | 20.00000 | 30.00000 | |
| cheese: | - | - | |
| chewing gum: | 20.00000 | 50.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | 10.00000 | 30.00000 | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | 10.00000 | 30.00000 | |
| fruit ices: | 10.00000 | 30.00000 | |
| gelatins / puddings: | 10.00000 | 30.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | 10.00000 | 30.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | 10.00000 | 30.00000 | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | 5.00000 | 20.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | 10.00000 | 30.00000 | |
| soups: | 10.00000 | 20.00000 | |
| sugar substitutes: | 10.00000 | 30.00000 | |
| sweet sauces: | - | - | |
Safety References:
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 614-60-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 637540 |
| National Institute of Allergy and Infectious Diseases: | Data |
| (E)-3-(2-hydroxyphenyl)prop-2-enoic acid | |
| Chemidplus: | 0000614608 |
| RTECS: | GD9090000 for cas# 614-60-8 |
References:
| (E)-3-(2-hydroxyphenyl)prop-2-enoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 637540 |
| Pubchem (sid): | 134977103 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C01772 |
| HMDB (The Human Metabolome Database): | HMDB02641 |
| FooDB: | FDB002589 |
| Export Tariff Code: | 2918.29.7500 |
| FDA Listing of Food Additive Status: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| coffee Search PMC Picture | |
| mikania laevigata shultz bip. ex baker Search Trop Picture |
Synonyms:
| cinnamic acid, o-hydroxy-, (E)- | |
| (E)-o- | coumaric acid |
| o-trans- | coumaric acid |
| trans-2- | coumaric acid |
| trans-o- | coumaric acid |
| trans-ortho- | coumaric acid |
| (E)-2- | hydroxycinnamic acid |
| (E)-o- | hydroxycinnamic acid |
| (E)-ortho- | hydroxycinnamic acid |
| trans-2- | hydroxycinnamic acid |
| trans-o- | hydroxycinnamic acid |
| trans-ortho- | hydroxycinnamic acid |
| 2- | hydroxycinnamic acid (predominantly trans) |
| 2- | hydroxycinnamic acid, (E)- |
| 2- | hydroxycinnamic acid, predominantly trans |
| (2E)-3-(2- | hydroxyphenyl)-2-propenoic acid |
| (E)-3-(2- | hydroxyphenyl)-2-propenoic acid |
| trans-3-(2- | hydroxyphenyl)-2-propenoic acid |
| (2E)-3-(2- | hydroxyphenyl)acrylic acid |
| (E)-3-(2- | hydroxyphenyl)acrylic acid |
| (2E)-3-(2- | hydroxyphenyl)prop-2-enoic acid |
| (E)-3-(2- | hydroxyphenyl)prop-2-enoic acid |
| trans-3-(2- | hydroxyphenyl)prop-2-enoic acid |
| 2- | propenoic acid, 3-(2-hydroxyphenyl)-, (2E)- |
| 2- | propenoic acid, 3-(2-hydroxyphenyl)-, (E)- |