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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 42.00 to 44.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 317.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 317.00 to 318.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 302.00 °F. TCC ( 150.00 °C. )
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| logP (o/w): | 1.880 |
| Soluble in: |
| | alcohol | | | water, 1317 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
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| Flavor Type: bitter |
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| | bitter musty |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 475 mg/kg Journal of Medicinal Chemistry. Vol. 14, Pg. 551, 1971.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for 2-benzoyl pyridine usage levels up to: | | | not for fragrance use.
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| Recommendation for 2-benzoyl pyridine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | benzoylpyridine | | | ketone, phenyl 2-pyridyl | | | methanone, phenyl-2-pyridinyl- | | | phenyl (pyridin-2-yl) methanone | | | phenyl 2-pyridyl ketone | | | phenyl pyridin-2-yl ketone | | | phenyl-2-pyridinylmethanone | | | phenyl-a-pyridylketone | | | phenyl-pyridin-2-yl-methanone | | | phenyl(pyridin-2-yl)methanone | | | pyridine, 2-benzoyl- | | 2- | pyridyl phenyl ketone |
Articles:
| US Patents: | 3,952,024 - Furfurylthioacetone |
| PubMed: | Structural studies and antileishmanial activity of 2-acetylpyridine and 2-benzoylpyridine nitroimidazole-derived hydrazones |
| US Patents: | Certain 2,5-dimethyl-3-thiopyrazines |
| PubMed: | 2-Benzoylpyridine Ligand Complexation with Gold Critical for Propargyl Ester-Based Protein Labeling |
| PubMed: | Rhodium (II) complex with 2-benzoylpyridine, a novel potential chemotherapeutic drug, induces cell cycle arrest and apoptosis in HepG2 cells |
| PubMed: | [Ag(L)NO(3)] Complexes with 2-Benzoylpyridine-Derived Hydrazones: Cytotoxic Activity and Interaction with Biomolecules |
| PubMed: | Interesting copper(ii)-assisted transformations of 2-acetylpyridine and 2-benzoylpyridine |
| PubMed: | 2-Acetylpyridine- and 2-benzoylpyridine-derived hydrazones and their gallium(III) complexes are highly cytotoxic to glioma cells |
| PubMed: | Anticancer Activity of Platinum (II) Complex with 2-Benzoylpyridine by Induction of DNA Damage, S-Phase Arrest, and Apoptosis |
| PubMed: | 2-Benzoylpyridine thiosemicarbazone as a novel reagent for the single pot synthesis of dinuclear Cu(I)-Cu(II) complexes: formation of stable copper(II)-iodide bonds |
| PubMed: | Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity |
| PubMed: | Antimony(III) complexes with 2-benzoylpyridine-derived thiosemicarbazones: cytotoxicity against human leukemia cell lines |
| PubMed: | Bismuth(III) complexes with 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones: Antimicrobial and cytotoxic activities and effects on the clonogenic survival of human solid tumor cells |
| PubMed: | Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance |
| PubMed: | Less toxic zinc(ii), diorganotin(iv), gallium(iii) and cadmium(ii) complexes derived from 2-benzoylpyridine N,N-dimethylthiosemicarbazone: synthesis, crystal structures, cytotoxicity and investigations of |
| PubMed: | Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinas |
| PubMed: | Synthesis, anti-bacterial evaluation, DFT study and molecular docking as a potential 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2 inhibitors of a novel Schiff bases |
| PubMed: | Correction to [Ag(L)NO(3)] Complexes with 2-Benzoylpyridine-Derived Hydrazones: Cytotoxic Activity and Interaction with Biomolecules |
| PubMed: | Synthesis, crystal structures, and biological evaluation of Cu(II) and Zn(II) complexes of 2-benzoylpyridine Schiff bases derived from S-methyl- and S-phenyldithiocarbazates |
| PubMed: | Oxidovanadium(IV) and dioxidovanadium(V) complexes of hydrazones of 2-benzoylpyridine and their catalytic applications |
| PubMed: | Syntheses and Structures of the Complexes cis-[M(C(6)F(5))(2)(N&arcraise;X)] (M = Pd, Pt; N&arcraise;X = 2-Iodoaniline, 2-Benzoylpyridine) Containing N&arcraise;X Acting as a Didentate Chelating Ligand and |
| PubMed: | Unravelling the reaction mechanism for the fast photocyclisation of 2-benzoylpyridine in aqueous solvent by time-resolved spectroscopy and density functional theory calculations |
| PubMed: | Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation |
| PubMed: | Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: structure-activity relationship studies on their anti-proliferative and iron chelation efficacy |
| PubMed: | Structure-activity studies of 4-phenyl-substituted 2'-benzoylpyridine thiosemicarbazones with potent and selective anti-tumour activity |
| PubMed: | Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligan |
| PubMed: | The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonuc |
| PubMed: | Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: novel structure-activity relationships underpinning their anti-proliferative and chelation efficacy |
| PubMed: | 2-Benzoylpyridine-N(4)-tolyl thiosemicarbazones and their palladium(II) complexes: cytotoxicity against leukemia cells |
| PubMed: | Carbon-Phosphorus Coupling from C^N Cyclometalated Au(III) Complexes |
| PubMed: | Cytotoxicity and structure-activity relationships of four alpha-N-heterocyclic thiosemicarbazone derivatives crystal structure of 2-acetylpyrazine thiosemicarbazone |
| PubMed: | Flame AAS and UV-VIS determination of cobalt, nickel and palladium using the synergetic effect of 2-benzoylpyridine-2-pyridylhydrazone and thiocyanate ions |
| PubMed: | Palladium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones: spectral characterization, structural studies and cytotoxic activity |
| PubMed: | Ruthenium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones with cytotoxic activity against human tumor cell lines |
| PubMed: | Excited electronic states and Raman spectra of 2-benzoylpyridine |
| PubMed: | Ruthenium(II) complexes containing 2-pyridineformamide- and 2-benzoylpyridine-derived thiosemicarbazones and PPh3: NMR and electrochemical studies of cis-trans-isomerization |
| PubMed: | Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes |
| PubMed: | Rhodium-Catalyzed Pyridine N-Oxide Assisted Suzuki-Miyaura Coupling Reaction via C(O)-C Bond Activation |
| PubMed: | Multifunctional Reactive MALDI Matrix Enabling High-Lateral Resolution Dual Polarity MS Imaging and Lipid CÍC Position-Resolved MS(2) Imaging |
| PubMed: | 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity |
| PubMed: | Towards blue emitting monocyclometalated gold(iii) complexes - synthesis, characterization and photophysical investigations |
| PubMed: | Synthesis, structure and reactivity of rare-earth metallacarborane alkyls [?(1):?(5)-O(CH2)2C2B9H9]Ln(ĺ:?(1)-CH2C6H4-o-NMe2)(THF)2 |
| PubMed: | Multiple Cycloaddition Reactions of Ketones with a ?-Diketiminate Al Compound |
| PubMed: | Cyclometalated Au(III) Complexes for Cysteine Arylation in Zinc Finger Protein Domains: towards Controlled Reductive Elimination |
| PubMed: | Spectral characterization and crystal structure of 2-benzoylpyridine nicotinoyl hydrazone |
| PubMed: | Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor ag |
| PubMed: | Benchmarking Water Oxidation Catalysts Based on Iridium Complexes: Clues and Doubts on the Nature of Active Species |
| PubMed: | Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: synthesis, characterization, X-ray crystal structures and antitumor comparison |
| PubMed: | Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous admini |
| PubMed: | Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes |
| PubMed: | Concentration-dependent surface-enhanced Raman scattering of 2-benzoylpyridine adsorbed on colloidal silver particles |
| PubMed: | Two azido-bridged homospin Fe(ii)/Co(ii) coordination polymers featuring single-chain magnet behavior |
| PubMed: | Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers |
| PubMed: | The medicinal chemistry of novel iron chelators for the treatment of cancer |
| PubMed: | LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT |
| PubMed: | Design and characterization of Cu(II) complexes from 2-benzoylpyridine benzhydrazone: crystallographic evidence for coordination versatility |
| PubMed: | Antifungal and antitumor activity of heterocyclic thiosemicarbazones and their metal complexes: current status |
| PubMed: | Synthesis and spectral characterization of mono- and binuclear copper(II) complexes derived from 2-benzoylpyridine-N?-methyl-3-thiosemicarbazone: crystal structure of a novel sulfur bridged copper(II) box- |
| PubMed: | Gold(I) complexes with thiosemicarbazones: cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity |
| PubMed: | Reaction of ?-diketiminate tin(II) dimethylamide LSnNMe? [L = HC(CMeNAr)?; Ar = 2,6-iPr?C?H?] with ketones and alkynes |
| PubMed: | Four Cu(ii) complexes based on antitumor chelators: synthesis, structure, DNA binding/damage, HSA interaction and enhanced cytotoxicity |
| PubMed: | Application of the deford and hume method modified for quasi-reversible and irreversible processes to the chelates of Bi(III) with azomethine derivatives of 2-benzoylpyridine |
| PubMed: | Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents |
| PubMed: | Beckmann rearrangement of the oximes of phenyl 2-pyridyl ketone (2-benzoylpyridine) |
| PubMed: | Synthesis, cytotoxic and antimalarial activities of benzoyl thiosemicarbazone analogs of isoquinoline and related compounds |
| PubMed: | Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism |
| PubMed: | Spectral characterization of iron(III) complexes of 2-benzoylpyridine N(4)-substituted thiosemicarbazones |
| PubMed: | In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites |
| PubMed: | Substituted pyridines: nonsteroidal inhibitors of human placental aromatase cytochrome P-450 |
| PubMed: | Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy |
| PubMed: | Multidrug Delivery Systems Based on Human Serum Albumin for Combination Therapy with Three Anticancer Agents |
| PubMed: | Drug metabolizing enzyme induction by simple diaryl pyridines; 2-substituted isomers selectively increase only conjugation enzyme activities, 4-substituted isomers also induce cytochrome P450 |
| PubMed: | Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents |
| PubMed: | Transformation of a Cp*-iridium(III) precatalyst for water oxidation when exposed to oxidative stress |
| PubMed: | Synthesis and solid state characterisation of mononuclear 2-benzoylpyridine N-methyl-N-phenylhydrazone palladium(II) complexes |
| PubMed: | Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells |
| PubMed: | Compositional and structural variety of diphenyllead(IV) complexes obtained by reaction of diphenyllead dichloride with thiosemicarbazones |
| PubMed: | ROS-mediated cytotoxic effect of copper(II) hydrazone complexes against human glioma cells |
| PubMed: | Aggregation tendency and reactivity toward AgX of cationic half-sandwich ruthenium(II) complexes bearing neutral N,O-ligands |
| PubMed: | Exploring the effect of the ligand design on the interactions between [Ru(?(5)-C5H5)(PPh3)(N,O)][CF3SO3] complexes and human serum albumin |
| PubMed: | Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer |
| PubMed: | Pyridine-derived thiosemicarbazones and their tin(IV) complexes with antifungal activity against Candida spp |
| PubMed: | Electrospray ionization mass spectrometry in the structural characterization of some diphenyllead(IV) thiosemicarbazonates |
| PubMed: | [Tridentate N-N-N chelating systems as potential antitumor agents] |
| PubMed: | Variable-Valent Re&tbd1;NAr Species. A Family of Re(VI)NAr Amide Complexes and Their Re(V)NAr Imine Precursors Related by Oxygen Atom Transfer |
| PubMed: | Simultaneous determination of the novel thiosemicarbazone anti-cancer agent, Bp4eT, and its main phase I metabolites in plasma: application to a pilot pharmacokinetic study in rats |
| PubMed: | Development of an LC-MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT |
| PubMed: | In situ tetrazole templated chair-like decanuclear azido-cobalt(II) SMM containing both tetra- and octa-hedral Co(II) ions |
| PubMed: | Carbonyl reductase activity exhibited by pig testicular 20 beta-hydroxysteroid dehydrogenase |
| PubMed: | Remote functionalisation via sodium alkylamidozincate intermediates: access to unusual fluorenone and pyridyl ketone reactivity patterns |
| PubMed: | Indirect determination of free cyanide in industrial waste effluent by atomic absorption spectrometry |
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