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Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 199.00 to 200.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 406.00 to 407.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 417.00 °F. TCC ( 214.00 °C. ) (est)
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| logP (o/w): | 1.740 |
| Soluble in: |
| | alcohol | | | water, 5000 mg/L @ 5C (exp) |
| Insoluble in: |
| | water |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-rat LD50 3000 mg/kg Bollettino Chimico Farmaceutico. Vol. 112, Pg. 53, 1973.
oral-mouse LD50 4500 mg/kg British Journal of Pharmacology and Chemotherapy. Vol. 8, Pg. 30, 1953.
intravenous-mouse LD50 374 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 254, 1953.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic agents |
| Recommendation for 2,5-dihydroxybenzoic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for 2,5-dihydroxybenzoic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoic acid, 2,5-dihydroxy- | | 2,5- | dihydroxy benzoic acid | | 2,5- | dihydroxy-benzoic acid | | 2,5- | dihydroxybenzoicacid | | | gentisic acid | | | hydroquinonecarboxylic acid |
Articles:
| PubMed: | Hydroxybenzoic acid isomers and the cardiovascular system. |
| PubMed: | Antioxidant and anti-inflammatory activities of methanol extracts of Tremella fuciformis and its major phenolic acids. |
| PubMed: | Quality and characteristics of ginseng seed oil treated using different extraction methods. |
| PubMed: | Anticholinesterase activity of phenolic acids and their derivatives. |
| PubMed: | Application of ultraperformance liquid chromatography/mass spectrometry-based metabonomic techniques to analyze the joint toxic action of long-term low-level exposure to a mixture of organophosphate pesticides on rat urine profile. |
| PubMed: | Analysis of phenolic compounds in olive oil by solid-phase extraction and ultra high performance liquid chromatography-tandem mass spectrometry. |
| PubMed: | Screening for anti-nutritional compounds in complementary foods and food aid products for infants and young children. |
| PubMed: | Antioxidant activity of brazilian vegetables and its relation with phenolic composition. |
| PubMed: | Potential for food-drug interactions by dietary phenolic acids on human organic anion transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11). |
| PubMed: | Beer fingerprinting by Matrix-Assisted Laser Desorption-Ionisation-Time of Flight Mass Spectrometry. |
| PubMed: | Enhancement of soluble dietary fibre, polyphenols and antioxidant properties of chapatis prepared from whole wheat flour dough treated with amylases and xylanase. |
| PubMed: | Structure and function of the oxidation products of polyphenols and identification of potent lipoxygenase inhibitors from Fe-catalyzed oxidation of resveratrol. |
| PubMed: | Simultaneous analysis of acetaminophen, p-aminophenol and aspirin metabolites by hydrophilic interaction and strong anion exchange capillary liquid chromatography coupled to amperometric detection. |
| PubMed: | Antioxidant activities, total phenolics and HPLC analyses of the phenolic compounds of extracts from common Mediterranean plants. |
| PubMed: | Polyphenols of pseudostem of different banana cultivars and their antioxidant activities. |
| PubMed: | Analytical determination and pharmacokinetics of major metabolites of carbasalate calcium in broilers following oral administration. |
| PubMed: | Study of the polyphenolic composition and antioxidant activity of new sherry vinegar-derived products by maceration with fruits. |
| PubMed: | Characterization of bioactive compounds from raw and ripe Mangifera indica L. peel extracts. |
| PubMed: | Chemical composition of Solanum nigrum linn extract and induction of autophagy by leaf water extract and its major flavonoids in AU565 breast cancer cells. |
| PubMed: | Chemical profiling of lentil (Lens culinaris Medik.) Cultivars and isolation of compounds. |
| PubMed: | Extraction, quantification, and antioxidant activities of phenolics from pericarp and seeds of bitter melons (Momordica charantia) harvested at three maturity stages (immature, mature, and ripe). |
| PubMed: | Antioxidant activity and chemical difference in fruit of different Actinidia sp. |
| PubMed: | Analysis of melamine cyanurate in urine using matrix-assisted laser desorption/ionization mass spectrometry. |
| PubMed: | Blackcurrant seed press residue increases tocopherol concentrations in serum and stool whilst biomarkers in stool and urine indicate increased oxidative stress in human subjects. |
| PubMed: | MALDI-TOF/MS fingerprinting of triacylglycerols (TAGs) in olive oils produced in the Israeli Negev desert. |
| PubMed: | Determination of the antioxidant capacity of active food packagings by in situ gas-phase hydroxyl radical generation and high-performance liquid chromatography-fluorescence detection. |
| PubMed: | Antioxidant activity of indigenous edible mushrooms. |
| PubMed: | Rapid identification of betacyanins from Amaranthus tricolor, Gomphrena globosa, and Hylocereus polyrhizus by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight mass spectrometry (MALDI-QIT-TOF MS). |
| PubMed: | Modulation of hepatic phase II phenol sulfotransferase and antioxidant status by phenolic acids in rats. |
| PubMed: | Selective extraction of derivates of p-hydroxy-benzoic acid from plant material by using a molecularly imprinted polymer. |
| PubMed: | Induction of hepatic antioxidant enzymes by phenolic acids in rats is accompanied by increased levels of multidrug resistance-associated protein 3 mRNA expression. |
| PubMed: | Characterization of intact Penicillium spores by matrix-assisted laser desorption/ionization mass spectrometry. |
| PubMed: | Effect of vegetables on human phenolsulfotransferases in relation to their antioxidant activity and total phenolics. |
| PubMed: | Induction of phenolsulfotransferase expression by phenolic acids in human hepatoma HepG2 cells. |
| PubMed: | Evaluation of antioxidant capacity of cereal brans. |
| PubMed: | Synergistic effect of antioxidant phenolic acids on human phenolsulfotransferase activity. |
| PubMed: | Effects of phenolic acids on human phenolsulfotransferases in relation to their antioxidant activity. |
| PubMed: | Pathways for 3-chloro- and 4-chlorobenzoate degradation in Pseudomonas aeruginosa 3mT. |
| PubMed: | MALDI-TOF MS analysis of isoflavones in soy products. |
| PubMed: | MALDI-TOF MS quantification of coccidiostats in poultry feeds. |
| PubMed: | [Phenolic acid intake of adults in a Bavarian subgroup of the national food consumption survey]. |
| PubMed: | Detection of salicylate and its hydroxylated adducts 2,3- and 2,5-dihydroxybenzoic acids as possible indices for in vivo hydroxyl radical formation in combination with catechol- and indoleamines and their metabolites in cerebrospinal fluid and brain tissue. |
| PubMed: | Evaluation of hydroxyl radical-scavenging property of purpurogallin using high pressure liquid chromatography. |
| PubMed: | The blocking effect of phenolic acid on N-nitrosomorpholine formation in vitro. |
| PubMed: | Effect of different isomers of dihydroxybenzoic acids (DBA) on the rate of DL-dopa oxidation by mushroom tyrosinase. |
| PubMed: | [Breeding of a biotype of Myzus persicae sulzer on a synthetic medium. V- Influence of oxalic and gentisic acids on the nutritive value of a synthetic medium]. |
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