Articles:
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2,4-diaminohypoxanthine
Notes:
2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective inhibitor of GTP cyclohydrolase I (GTPCH) that restricts the de novo synthesis of tetrahydrobiopterin (BH4) or the BH4 precursor in vascular smooth muscle cells (VSMC). (PMID 12883322)
2,4-Diamino-6-hydroxypyrimidine also inhibits nitric oxide (NO) in both Interferon-gamma (IFN-gamma) and antigen (Ag)/IgE (Ag/IgE) systems, increasing Mast cells (MC) degranulation. (PMID 14514683)
Sepiapterin, a precursor to tetrahydrobiopterin in the salvage pathway, completely reverses the effect of 2,4-diamino-6-hydroxypyrimidine on neuronal NO-synthase (nNOS) ubiquitylation. (PMID 16216381) [HMDB]
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Beijing Lys Chemicals Co, LTD. From Grams to Tons Fine chemical high-tech company which contains R&D, production, and sales. BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services. Email: Mr. Jia Email: Mr. Guo Voice: 86-10-68418738 Fax: 86-10-68418739 Mr. Guo 86-10-68483445 Mr. Guo 86-10-68418739 News Product(s): 30091 2,4-Diamino-6-hydroxypyrimidine
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| CAS Number: | 56-06-4 |  3D/inchi
|
| Other(deleted CASRN): | 40306-60-3 | |
| ECHA EINECS - REACH Pre-Reg: | 200-254-4 | |
| FDA UNII: | EDH7CNS75I | |
| Nikkaji Web: | J41.153A | |
| Beilstein Number: | 125006 | |
| MDL: | MFCD00006098 | |
| XlogP3-AA: | -1.80 (est) | |
| Molecular Weight: | 126.11902000 | |
| Formula: | C4 H6 N4 O | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| DG SANTE Food Contact Materials: | 2,4-diamino-6-hydroxypyrimidine |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Soluble in: | |
| water, 8.585e+005 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Beijing Lys Chemicals |
| 2,4-Diamino-6-hydroxypyrimidine |
| BOC Sciences |
| For experimental / research use only. |
| 2,4-Diamino-6-hydroxypyrimidine ≥99%
Odor: characteristic Use: 2,4-Diamino-6-hydroxypyrimidine has been found to be a GCH1 inhibitor and coul |
| EMD Millipore |
| For experimental / research use only. |
| 2,4-Diamino-6-hydroxypyrimidine |
| Matrix Scientific |
| For experimental / research use only. |
| 2,4-Diamino-6-hydroxypyrimidine, 95+% |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 2,4-Diamino-6-hydroxypyrimidine ≥98% |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 2,4-Diamino-6-hydroxypyrimidine 96% |
| TCI AMERICA |
| For experimental / research use only. |
| 2,4-Diamino-6-hydroxypyrimidine >98.0%(HPLC)(T) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | indirect food additives: adhesives and components of coatings | ||
| Recommendation for 2,4-diamino-6-hydroxypyrimidine usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for 2,4-diamino-6-hydroxypyrimidine flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| European Food Safety Authority (EFSA) reference(s): | |
| Scientific Opinion on the safety evaluation of the substance, 2,4-diamino-6-hydroxypyrimidine, CAS No. 56-06-4, for use in food contact materials View page or View pdf | |
| EPI System: | View |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 56-06-4 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 2944 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| 2,6-diamino-1H-pyrimidin-4-one | |
| Chemidplus: | 0000056064 |
References:
| 2,6-diamino-1H-pyrimidin-4-one | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 56-06-4 |
| Pubchem (cid): | 2944 |
| Pubchem (sid): | 135021950 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | HMDB02128 |
| FooDB: | FDB022857 |
| Export Tariff Code: | 2933.59.9500 |
| ChemSpider: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| 2- | aminoisocytosine |
| 2,6- | diamino-1H-pyrimidin-4-one |
| 2,6- | diamino-4(1H)-pyrimidinone |
| 2,4- | diaminohypoxanthine |
| 4(3H)- | pyrimidinone, 2,6-diamino- |