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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 145.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 300.00 °C. @ 760.00 mm Hg
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| Soluble in: |
| | water, 3190 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for 2,4,5-trimethoxybenzoic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for 2,4,5-trimethoxybenzoic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzoic acid, 2,4,5-trimethoxy- |
Articles:
| PubMed: | [Chemical constituents from traditional Chinese medicine Siegesbeckia pubescens]. |
| PubMed: | Supramolecular association in proton-transfer adducts containing benzamidinium cations. III. Three molecular salts of 3-methoxy-, 4-methoxy- and 3,4,5-trimethoxybenzoates with benzamidine. |
| PubMed: | Hexanuclear and undecanuclear iron(III) carboxylates as catalyst precursors for cyclohexane oxidation. |
| PubMed: | Gypenosides induce apoptosis by ca2+ overload mediated by endoplasmic-reticulum and store-operated ca2+ channels in human hepatoma cells. |
| PubMed: | A case of trimebutine-induced anaphylaxis. |
| PubMed: | Inhibitory effects of constituents from Euphorbia lunulata on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells. |
| PubMed: | The novel potent multidrug resistance inhibitors N,N-bis(cyclohexanol)amine aryl esters are devoid of vascular effects. |
| PubMed: | Regulation of renin release by connexin 43 in As 4.1 cell line. |
| PubMed: | A role for the Val291 residue within the transmembrane domain 2 in diltiazem- and TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester]-mediated 5-hydroxytryptamine type 3A receptor regulations. |
| PubMed: | Chemical constituents from leaves of Palicourea coriacea (Rubiaceae). |
| PubMed: | Thermally assisted hydrolysis and methylation of purified tannins from plants. |
| PubMed: | DdAlix, an Alix/AIP1 homolog in Dictyostelium discoideum, is required for multicellular development under low Ca2+ conditions. |
| PubMed: | Trypanocidal tetrahydrofuran lignans from inflorescences of Piper solmsianum. |
| PubMed: | Involvement of calcium/calmodulin signaling in cercosporin toxin biosynthesis by Cercospora nicotianae. |
| PubMed: | Role of PKC and calcium in modulation of effects of angiotensin II on sodium transport in proximal tubule. |
| PubMed: | Quantitative determination of trimebutine maleate and its three metabolites in human plasma by liquid chromatography-tandem mass spectrometry. |
| PubMed: | New flavonol-phenylbutadiene adducts from the leaves of Alpinia flabellata. |
| PubMed: | Regulation of nitric oxide production by murine peritoneal macrophages treated in vitro with chemokine monocyte chemoattractant protein 1. |
| PubMed: | Endothelin-1 decreases glutamate uptake in primary cultured rat astrocytes. |
| PubMed: | Biodegradation of synthetic and naturally occuring mixtures of mono-cyclic aromatic compounds present in olive mill wastewaters by two aerobic bacteria. |
| PubMed: | Ca++ regulation of paracellular permeability in the middle intestine of the eel, Anguilla anguilla. |
| PubMed: | Tumor necrosis factor-alpha induces distinctive NF-kappa B signaling within human dermal fibroblasts. |
| PubMed: | Insulin enhances the bradykinin response in L8 rat skeletal myoblasts. |
| PubMed: | Antimicrobial activity of Mitracarpus scaber extract and isolated constituents. |
| PubMed: | Differential acetylcholine release mechanisms in the ischemic and non-ischemic myocardium. |
| PubMed: | Hypoxia/aglycemia increases endothelial permeability: role of second messengers and cytoskeleton. |
| PubMed: | Effect of 3,4,5-trimethoxybenzoic acid 8-diethylamino-octyl ester (TMB-8) on neuronal calcium homeostasis, protein synthesis, and energy metabolism. |
| PubMed: | Very low density lipoprotein-mediated signal transduction and plasminogen activator inhibitor type 1 in cultured HepG2 cells. |
| PubMed: | Characterization of interaction of 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester with Torpedo californica nicotinic acetylcholine receptor and 5-hydroxytryptamine3 receptor. |
| PubMed: | Calcium recruitment in renal vasculature: NE effects on blood flow and cytosolic calcium concentration. |
| PubMed: | Mibefradil-induced inhibition of proliferation of human peripheral blood mononuclear cells. |
| PubMed: | Trimebutine: mechanism of action, effects on gastrointestinal function and clinical results. |
| PubMed: | Different mechanisms mediate development and expression of tolerance and dependence for peripheral mu-opioid antinociception in rat. |
| PubMed: | Granulocyte colony-stimulating factor-induced activation of protein kinase-C in myeloid cells. |
| PubMed: | Effect of oxidative stress on cellular functions and cytosolic free calcium of rat pancreatic acinar cells. |
| PubMed: | Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors. |
| PubMed: | Involvement of intracellular or extracellular calcium in activation of tyrosine hydroxylase gene expression in PC12 cells. |
| PubMed: | The "calcium antagonist" TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester] is a potent, non-competitive, functional antagonist at diverse nicotinic acetylcholine receptor subtypes. |
| PubMed: | The effects of calcium antagonists on anthrone skin tumor promotion and promoter-related effects in SENCAR mice. |
| PubMed: | Glyburide attenuates calmodulin antagonist-stimulated renin release from isolated mouse juxtaglomerular cells. |
| PubMed: | Influence of Ca2+ channel modulators on [3H]purine release from rat cultured glial cells. |
| PubMed: | Role of calcium ion in platelet serotonin uptake regulation. |
| PubMed: | Lysophosphatidylcholine causes Ca2+ influx, enhanced DNA synthesis and cytotoxicity in cultured vascular smooth muscle cells. |
| PubMed: | Ca2+ mobilization by caffeine in single smooth muscle cells of the rat tail artery. |
| PubMed: | Angiotensin II-dependent proximal tubule sodium transport is mediated by cAMP modulation of phospholipase C. |
| PubMed: | Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells. |
| PubMed: | ATP inhibits the hydrosmotic effect of AVP in rabbit CCT: evidence for a nucleotide P2u receptor. |
| PubMed: | Characterization of low pH-induced catecholamine secretion in the rat adrenal medulla. |
| PubMed: | Calcium channel blockers inhibit hydrogen peroxide-induced proliferation of cultured rat mesangial cells. |
| PubMed: | Interrelationship between cell pH and cell calcium in rat inner medullary collecting duct cells. |
| PubMed: | Dynamics of intracellular free Mg2+ changes in a vascular smooth muscle cell line. |
| PubMed: | Cytosolic free calcium regulation in response to acute changes in intracellular pH in vascular smooth muscle. |
| PubMed: | Microbore liquid chromatography with electrochemical detection for the control of phenolic antioxidants in drugs and foods. |
| PubMed: | Effects of modulators of cytosolic Ca2+ on phytohemagglutin-dependent Ca2+ response and interleukin-2 production in Jurkat cells. |
| PubMed: | Neurally mediated actions of leukotrienes on ion transport in guinea pig distal colon. |
| PubMed: | Modulation by intracellular calcium pool of arginine vasopressin-induced cellular cyclic AMP production in rat renal papillary collecting tubule cells in culture. |
| PubMed: | Involvement of the Y-1 receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats. |
| PubMed: | Calcium current and charge movement of mammalian muscle: action of amyotrophic lateral sclerosis immunoglobulins. |
| PubMed: | Characterization of bradykinin mediating pertussis toxin-insensitive biphasic response in circular muscle of the isolated guinea pig ileum. |
| PubMed: | Effect of intracellular pH on cytosolic free [Ca2+] in human epidermoid A-431 cells. |
| PubMed: | Bradykinin induces elevations of cytosolic calcium through mobilisation of intracellular and extracellular pools in bovine aortic endothelial cells. |
| PubMed: | Calcium-dependent natural killer and calcium-independent natural cytotoxic activities in an IL-2-dependent killer cell line. |
| PubMed: | Integrated autonomic and behavioral responses to L/N Ca2(+)-channel blocker omega-conotoxin in conscious rats. |
| PubMed: | Chloride efflux in cyclic AMP-induced configurational change of bovine pulmonary artery endothelial cells. |
| PubMed: | Occult intracellular calcium pools: relevance to neutrophil oxidant production. |
| PubMed: | Arginine vasopressin promotes growth of rat glomerular mesangial cells in culture. |
| PubMed: | Does protein kinase C activation mediate thrombin-induced arachidonate release in human platelets? |
| PubMed: | Leukotriene B4 triggers highly characteristic and specific functional responses in neutrophils: studies of stimulus specific mechanisms. |
| PubMed: | Prostanoid formation in primary astroglial cell cultures: Ca(2+)-dependency and stimulation by A 23187, melittin and phospholipases A(2) and C. |
| PubMed: | Enhancement of the expression of a rat neutrophil-specific cell surface antigen by activation with phorbol myristate acetate and concanavalin A. |
| PubMed: | Influence of calcium and other divalent cations on protein turnover in rat skeletal muscle. |
| PubMed: | A pertussis toxin-sensitive GTP-binding protein in the human neutrophil regulates multiple receptors, calcium mobilization, and lectin-induced capping. |
| PubMed: | ATP-dependent [3H]Met-enkephalin uptake by bovine adrenal chromaffin granule membrane. |
| PubMed: | Studies on the mechanism of phorbol ester-induced inhibition of intercellular junctional communication. |
| PubMed: | Induction of methotrexate release from rat hepatocytes in suspension by alpha-adrenergic agents: involvement of calcium and metabolic energy. |
| PubMed: | [Synthesis and the study of the effect of new 3,4,5-trimethoxybenzoic acid derivatives on the central nervous system]. |
| PubMed: | The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia. |
| PubMed: | Aerobic and Anaerobic Catabolism of Vanillic Acid and Some Other Methoxy-Aromatic Compounds by Pseudomonas sp. Strain PN-1. |
| PubMed: | Bacterial degradation of 3,4,5-trimethoxycinnamic acid with production of methanol. |
| PubMed: | The search for new antiarrhythmics in the group of chirally 1,2-aminoalcohols. I. 3',4',5'-trimethoxybenzoic acid esters of optically active N,N'-dimethyl-N,N'-bis-(1-hydroxybutyl-2) ethylenediamines. |
| PubMed: | Investigations of anthelminthic activity and synthesis of new derivatives of perhydroazepine, perhydro-1,4-diazepine, perhydro-1,4-oxazepine and perhydro-1,5-oxazocine. |
| PubMed: | Catabolism of 2,4,5-trimethyoxybenzoic acid and 3-methoxycrotonic acid. |
| PubMed: | Biotransformation of trithiozine. III - Isolation and identification of further metabolites in rat urine. |
| PubMed: | Weak electrolyte transfer in the guinea pig jejunum: secretion of trimethoxybenzoic acid. |
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