Articles:
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3-hydroxysalicylic acid
Notes:
Occurs in Gentiana lutea (yellow gentian)
2-Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma (PMID 16351159), and is normally found with increased levels after consumption of many nutrients and drugs, i.e.: cranberry juice (PMID 14733499), aspirin ingestion. (PMID 3342084) It has been found associated with idiopathic oro-facial pain due to stress (oxidative stress might enhance the production of free radicals); it has been suggested that OH radicals are responsible for the production of many systemic and local tissue injury diseases which may initially manifest as pain syndrome, and 2-Pyrocatechuic acid is a biological marker for the detection and quantification of OH radicals, and patients had significantly increased circulating levels of 2-Pyrocatechuic acid after aspirin ingestion than control subjects. (PMID 7748148)
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| CAS Number: | 303-38-8 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 206-139-5 | |
| FDA UNII: | 70D5FBB392 | |
| Nikkaji Web: | J79.590I | |
| Beilstein Number: | 2209117 | |
| MDL: | MFCD00002446 | |
| XlogP3: | 1.20 (est) | |
| Molecular Weight: | 153.11365000 | |
| Formula: | C7 H5 O4 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Appearance: | cream to pale brown powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 204.00 to 208.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 362.00 to 363.00 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 369.00 °F. TCC ( 187.20 °C. ) (est) |
| logP (o/w): | 1.200 |
| Soluble in: | |
| alcohol | |
| water, 2.612e+004 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| 2,3-Dihydroxybenzoic acid |
| ExtraSynthese |
| For experimental / research use only. |
| 2,3-Dihydroxybenzoic Acid (HPLC) ≥90% |
| Matrix Scientific |
| For experimental / research use only. |
| 2,3-Dihydroxybenzoic acid, 97% |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 2,3-Dihydroxybenzoic Acid |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 2,3-Dihydroxybenzoic Acid 99% |
| TCI AMERICA |
| For experimental / research use only. |
| 2,3-Dihydroxybenzoic Acid >98.0%(HPLC)(T) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-rabbit LD50 > 3000 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 196, Pg. 478, 1976. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | natural substances and extractives | ||
| Recommendation for 2,3-dihydroxybenzoic acid usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for 2,3-dihydroxybenzoic acid flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 19 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| 2,3-dihydroxybenzoic acid | |
| Chemidplus: | 0000303388 |
| RTECS: | DG8576490 for cas# 303-38-8 |
References:
| 2,3-dihydroxybenzoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 19 |
| Pubchem (sid): | 134973442 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00196 |
| HMDB (The Human Metabolome Database): | HMDB00397 |
| FooDB: | FDB012200 |
| Export Tariff Code: | 2918.29.7500 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| evening-primrose plant Search Trop Picture | |
| gentian yellow gentian Search Trop Picture |
Synonyms:
| benzoic acid, 2,3-dihydroxy- | |
| catechol-3-carboxylic acid | |
| catecholcarboxylic acid | |
| 2,3- | dihdroxybenzoic acid |
| 2,3- | dihydroxybenzoicacid |
| 3- | hydroxysalicylic acid |
| 2- | pyrocatechuic acid |