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Category: cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 296.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 588.34 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 615.00 °F. TCC ( 323.70 °C. ) (est)
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| logP (o/w): | 5.498 (est) |
| Soluble in: |
| | water, 0.01138 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 308 mg/kg Drugs in Japan Vol. -, Pg. 319, 1990.
intravenous-mouse LD50 56 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02067
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| Dermal Toxicity: |
subcutaneous-mouse LD50 518 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 5, Pg. 98, 1963.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic ingredient for skin conditioning |
| Recommendation for 18-beta-glycyrrhetinic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for 18-beta-glycyrrhetinic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 471-53-4 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 10114 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid |
| Chemidplus: | 0000471534 |
| RTECS: | RK0180000 for cas# 471-53-4 |
References:
| | (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 10114 |
| Pubchem (sid): | 134975336 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | arthrodont | | | biosone | | | BX-1 | | | enoloxone | | | enoxolone | | | enoxolonum | | 18b- | glycyrrhetinic acid | | 18beta- | glycyrrhetinic acid | | | hidermart | | (3b,20b)-3- | hydroxy-11-oxoolean-12-en-29-oic acid | | 3b- | hydroxy-11-oxoolean-12-en-30-oic acid | | (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10- | hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid | | | rhetinic acid | | | uralenic acid |
Articles:
| PubMed: | 18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity. |
| PubMed: | Glycyrrhetinic Acid Suppressed NF-κB Activation in TNF-α-Induced Hepatocytes. |
| PubMed: | Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes. |
| PubMed: | Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. |
| PubMed: | Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. |
| PubMed: | Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation. |
| PubMed: | Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions. |
| PubMed: | In vitro and in vivo pharmacokinetics of two novel 1,3-cyclic propanyl phosphate ester prodrugs of 18β-glycyrrhetic acid in rats. |
| PubMed: | Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation. |
| PubMed: | Inhibition of human renin activity by saponins. |
| PubMed: | Determination of glycyrrhetic acid after consumption of liquorice and application to a fatality. |
| PubMed: | Licorice: a sweet alternative to prevent hyperkalemia in dialysis patients? |
| PubMed: | Glycyrrhetinic acid food supplementation lowers serum potassium concentration in chronic hemodialysis patients. |
| PubMed: | Glycyrrhizin and licorice significantly affect the pharmacokinetics of methotrexate in rats. |
| PubMed: | Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway. |
| PubMed: | Effect of the extracts from Glycyrrhiza uralensis Fisch on the growth characteristics of human cell lines: Anti-tumor and immune activation activities. |
| PubMed: | [Hypertension due to liquorice and liquorice tea consumption]. |
| PubMed: | Effects of 11beta-hydroxysteroid dehydrogenase inhibitor on body weight and glucose tolerance in Sprague-Dawley rats fed with a high-fat diet. |
| PubMed: | Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. |
| PubMed: | Simultaneous quantification of flavonoids and triterpenoids in licorice using HPLC. |
| PubMed: | Simultaneous HPLC analysis, with isocratic elution, of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products. |
| PubMed: | The old lady who liked liquorice: hypertension due to chronic intoxication in a memory-impaired patient. |
| PubMed: | Severe hypokalaemic paralysis and rhabdomyolysis due to ingestion of liquorice. |
| PubMed: | Different responsiveness in body weight and hepatic 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 mrna to 11beta-HSD inhibition by glycyrrhetinic acid treatment in obese and lean zucker rats. |
| PubMed: | Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats. |
| PubMed: | Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide. |
| PubMed: | Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation. |
| PubMed: | [Immunological study on the antitumor effects of fungus polysaccharides compounds]. |
| PubMed: | Efficient method for determining the glycyrrhizin content of fresh and dried roots, and root extracts, of Glycyrrhiza species. |
| PubMed: | The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling. |
| PubMed: | Isolation and identification of main constituents in an enzymatically hydrolysed licorice extract sweetener. |
| PubMed: | A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid. |
| PubMed: | Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling. |
| PubMed: | Localization of enzymes involved in metabolism of glycyrrhizin in contents of rat gastrointestinal tract. |
| PubMed: | Glycyrrhizic acid in liquorice--evaluation of health hazard. |
| PubMed: | Inhibition of mutagenicity in Salmonella typhimurium and skin tumor initiating and tumor promoting activities in SENCAR mice by glycyrrhetinic acid: comparison of 18 alpha- and 18 beta-stereoisomers. |
| PubMed: | The determination of glycyrrhizin in selected UK liquorice products. |
| PubMed: | Teratogenicity study of ammonium glycyrrhizinate in the Sprague-Dawley rat. |
| PubMed: | [Estimation of daily intake of glycyrrhizic acid according to the market basket studies in Japan (I)]. |
| PubMed: | [Glycyrrhizin levels in various food stuffs]. |
| PubMed: | Tests for mutagenic effects of ammoniated glycyrrhizin, butylated hydroxytoluene, and gum Arabic in rodent germ cells. |
| PubMed: | Tumorigenicity study of disodium glycyrrhizinate administered orally to mice. |
| PubMed: | Effects of carbenoxolone on gastric release of prostaglandin (PG)E2 in patients with peptic ulcer disease. |
| PubMed: | Effect of carbenoxolone on gastric prostaglandin E2 levels in patients with peptic ulcer disease following vagal and pentagastrin stimulation. |
| PubMed: | [STudies on the likelihood of growth of Streptococcus faecium following thermal treatment in meat suspensions (author's transl)]. |
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