p-phenylenediamine
4-phenylenediamine
 
Notes:
agent hair dye responsible for contact dermatitis.
  • ECSA Chemicals
    • ECSA Chemicals
      Human Chemistry
      ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide.
      ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators.
      Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials.
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      Product(s):
      MP-001679 P-PHENYLENEDIAMINE
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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      Product(s):
      P0170 p-Phenylenediamine >98.0%(GC)(T)
       
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CAS Number: 106-50-3Picture of molecule3D/inchi
Other(deleted CASRN): 56481-76-6
ECHA EINECS - REACH Pre-Reg: 203-404-7
FDA UNII: U770QIT64J
Nikkaji Web: J4.035E
Beilstein Number: 749029
MDL: MFCD00007901
XlogP3: -0.30 (est)
Molecular Weight: 108.14376000
Formula: C6 H8 N2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: hair dyeing agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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FDA Mainterm (IAUFC):106-50-3 ; P-PHENYLENEDIAMINE
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Physical Properties:
Appearance: white to purple crystalline solid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 146.00 °C. @ 760.00 mm Hg
Boiling Point: 267.00 °C. @ 760.00 mm Hg
Flash Point: > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): -0.300
Soluble in:
 water, 3.70E+04 mg/L @ 23C (exp)
 water, 1.99e+005 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: hair dyeing agents
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Suppliers:
ECSA Chemicals
P-PHENYLENEDIAMINE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
EMD Millipore
For experimental / research use only.
1,4-Phenylenediamine
Santa Cruz Biotechnology
For experimental / research use only.
1,4-Phenylenediamine
Sigma-Aldrich: Aldrich
For experimental / research use only.
p-Phenylenediamine sublimed, ≥99%
TCI AMERICA
For experimental / research use only.
p-Phenylenediamine >98.0%(GC)(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-bird - wild LD50  100 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

oral-cat LDLo  100 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

intravenous-dog LDLo  17 mg/kg
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

oral-guinea pig LD50  145 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(7), Pg. 62, 1988.

unreported-guinea pig LD50  145 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 46, 1987.

oral-man TDLo  71 mg/kg
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS
Human Toxicology. Vol. 8, Pg. 345, 1989.

intraperitoneal-mouse LD50  50 mg/kg
National Technical Information Service. Vol. AD277-689

unreported-mouse LD50  331 mg/kg
BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(6), Pg. 78, 1985.

oral-mouse LDLo  100 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 23(5), Pg. 14, 1958.

oral-quail LD50  100 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

intraperitoneal-rabbit LDLo  150 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928.

intravenous-rabbit LDLo  300 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Archives of Internal Medicine. Vol. 36, Pg. 724, 1925.

oral-rabbit LDLo  250 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

intraperitoneal-rat LD50  37 mg/kg
Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.

oral-rat LD50  80 mg/kg
Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.

unreported-rat LD50  133 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 46, 1987.

intravenous-rat LDLo  50 mg/kg
Bulletin de la Societe Royale des Sciences de Liege. Vol. 41, Pg. 302, 1972.

Dermal Toxicity:
subcutaneous-dog LDLo 100 mg/kg
BEHAVIORAL: COMA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: NAUSEA OR VOMITING
U.S. Public Health Service, Public Health Bulletin. Vol. 271, Pg. 40, 1941.

subcutaneous-mouse LDLo 140 mg/kg
Journal of the Society of Cosmetic Chemists. Vol. 12, Pg. 500, 1961.

skin-rabbit LDLo 5000 mg/kg
Journal of Toxicology and Environmental Health. Vol. 2, Pg. 657, 1977.

subcutaneous-rabbit LDLo 200 mg/kg
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

subcutaneous-rat LDLo 170 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Industrial Hygiene. Vol. 4, Pg. 386, 1923.

Inhalation Toxicity:
inhalation-rat LC50 920 mg/m3/4H
KIDNEY, URETER, AND BLADDER: HEMATURIA BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: NAUSEA OR VOMITING
National Technical Information Service. Vol. OTS0530403

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Safety in Use Information:
Category: hair dyeing agents
Recommendation for p-phenylenediamine usage levels up to:
 not for fragrance use.
 
Recommendation for p-phenylenediamine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Daily Med: search
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 106-50-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7814
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
WGK Germany: 3
 benzene-1,4-diamine
Chemidplus: 0000106503
EPA/NOAA CAMEO: hazardous materials
RTECS: 106-50-3
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References:
 benzene-1,4-diamine
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 106-50-3
Pubchem (cid): 7814
Pubchem (sid): 134971774
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C19499
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2921.51.5000
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
one technical grade of para-phenylenediamine available in the usa has the following specifications: purity, 99.2% minimum; moisture content, 0.1% maximum; ortho-phenylenediamine (1,2-diaminobenzene) content, 0.1% maximum; and iron content, 50 mgkg maximum.
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Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 hair dyeing agents 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
p-aminoaniline
 aminogen II
(4-aminophenyl)amine
4-aminophenylamine
 benzene-1,4-diamine
1,4-benzenediamine
p-benzenediamine
1,4-benzenediamine (9CI)
 benzofur D
 c.i. 76060
 C.I. developer 13
 C.I. oxidation base 10
 ci 76060
 developer 13
 developer PF
1,4-diaminobenzene
p-diaminobenzene
para-diaminobenzene
 durafur black R
p-fenylendiamin
 fouramine D
 fourrine 1
 fourrine D
 fur black 41867
 fur black R
 fur brown 41866
 fur yellow
 furro D
 futramine D
 nako H
 oxidation base 10
 pelagol D
 pelagol DR
 pelagol grey D
 peltol D
1,4-phenyldiamine
1,4-phenylene diamine
4-phenylene diamine
p-phenylene diamine
para-phenylene diamine (c.i. 76060)
 phenylenediamine
1,4-phenylenediamine
4-phenylenediamine
para-phenylenediamine
 phenylenediamine, para
 renal PF
 rodol D
 santoflex IC
 santoflex LC
 tertral D
 ursol D
 ursol-D
 vulkanox 4020
 zoba black D
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Oligomeric complexes of some heteroaromatic ligands and aromatic diamines with rhodium and molybdenum tetracarboxylates: (13) C and (15) N CPMAS NMR and density functional theory studies.
PubMed: Batchwise dyeing of bamboo cellulose fabric with reactive dye using ultrasonic energy.
PubMed: Application of mechanosynthesized azine-decorated zinc(II) metal-organic frameworks for highly efficient removal and extraction of some heavy-metal ions from aqueous samples: a comparative study.
PubMed: Photocatalytic applications with CdS • block copolymer/exfoliated graphene nanoensembles: hydrogen generation and degradation of Rhodamine B.
PubMed: Enhanced lifetime of organic light-emitting diodes using an anthracene derivative with high glass transition temperature.
PubMed: meso-Tetraphenylbenzoporphyrin-2(2),2(3)-dicarboxylic anhydride: a platform to benzoporphyrin derivatives.
PubMed: Conformational landscape, photochemistry, and infrared spectra of sulfanilamide.
PubMed: Synthesis and characterization of new donor-acceptor type copolymers based on fluorene derivatives for photovoltaic solar cells.
PubMed: N,N'-Bis[1-(pyridin-2-yl)-ethyl-idene]benzene-1,4-diamine.
PubMed: Poly[di-μ(3)-chlorido-di-μ(2)-chlorido-{μ(4)-N,N,N',N'-tetra-kis-[(diphenyl-phosphan-yl)meth-yl]benzene-1,4-diamine-κ(4)P:P':P'':P'''}tetra-copper(II)].
PubMed: Effect of the environment on the electrical conductance of the single benzene-1,4-diamine molecule junction.
PubMed: A third polymorph of N,N'-bis-(pyridin-2-yl)benzene-1,4-diamine.
PubMed: N,N'-Bis(4-methyl-benzyl-idene)benzene-1,4-diamine.
PubMed: (E,E)-N-(2,3,4,5,6-Penta-fluoro-benzyl-idene)-N-(3,4,5-trimeth-oxy-benzyl-idene)benzene-1,4-diamine.
PubMed: N,N'-Bis(pyridin-2-yl)benzene-1,4-diamine-naphthalene (2/1).
PubMed: N,N'-Bis(pyridin-2-yl)benzene-1,4-diamine-quinoxaline (2/1).
PubMed: N,N-Diethynyl-N,N-diphenyl-benzene-1,4-diamine.
PubMed: Tetra-aqua-bis-[N,N'-bis-(pyridin-3-yl-methyl-idene)benzene-1,4-diamine]-zinc dinitrate 1.49-hydrate.
PubMed: {μ-N,N,N',N'-Tetra-kis[(diphenyl-phosphan-yl)meth-yl]benzene-1,4-diamine}-bis-[(2,2'-bipyrid-yl)copper(I)] bis-(tetra-fluoridoborate).
PubMed: A centrosymmetric monoclinic polymorph of N,N-bis-(pyridin-3-yl-methyl-idene)benzene-1,4-diamine.
PubMed: 2,5-Bis{2,2-bis-[4-(dimethyl-amino)-phen-yl]ethen-yl}-N,N'-diphenyl-N,N'-dipropyl-benzene-1,4-diamine.
PubMed: Synthesis, structural characterization and luminescent properties of a series of Cu(I) complexes based on polyphosphine ligands.
PubMed: Conformational polymorphism of (E,E)-N,N'-bis(4-nitrobenzylidene)benzene-1,4-diamine.
PubMed: DNA binding, oxidative DNA cleavage, cytotoxicity, and apoptosis-inducing activity of copper(II) complexes with 1,4-tpbd (N,N,N',N'-tetrakis(2-yridylmethyl)benzene-1,4-diamine) ligand.
PubMed: 4-Salicylideneamino-3-methyl-1,2,4-triazole-5-thione as a sensor for aniline recognition.
PubMed: Novel on-site sample preparation approach with a portable agitator using functional polymer-coated multi-fibers for the microextraction of organophosphorus pesticides in seawater.
PubMed: Electrochemical degradation of aromatic amines on BDD electrodes.
PubMed: Design of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.
PubMed: N-[(E)-4-Chloro-benzyl-idene]-N'-phenyl-benzene-1,4-diamine.
PubMed: catena-Poly[[(nitrato-κO,O')silver(I)]-μ-N,N'-bis-(3-pyridyl-methyl-idene)benzene-1,4-diamine].
PubMed: Dichlorido[N-(2-pyridylmethyl-idene)benzene-1,4-diamine]zinc(II).
PubMed: Small molecule modulators of copper-induced Abeta aggregation.
PubMed: N,N-Diethyl-N'-[(E)-4-pyridylmethylene]benzene-1,4-diamine: a combined X-ray and density functional theory study.
PubMed: Synthesis, X-ray crystal structures, magnetism, and DNA cleavage properties of copper(II) complexes with 1,4-tpbd ligand.
PubMed: Self-assembly of 2D Borromean networks through hydrogen-bonding recognition.
PubMed: N,N'-Bis(2-thienylmethyl-ene)benzene-1,4-diamine.
PubMed: {μ-trans-N,N'-Bis[(diphenyl-phosphan-yl)meth-yl]benzene-1,4-diamine-κP:P'}bis-{(acetonitrile-κN)[dipyrido[3,2-a:2',3'-c]phenazine-κN,N]copper(I)} bis-(tetra-fluoridoborate).
PubMed: Self-assembly of triple helical and meso-helical cylindrical arrays tunable by bis-tripodal coordination converters.
PubMed: Final report on the safety assessment of HC Red No. 7.
PubMed: Self-assembly of a one-dimensional iron(II) coordination polymer with p-phenylenebis(picolinaldimine).
PubMed: [The expanding role of occupational and non-occupational allergy to paraphenylenediamine].
PubMed: N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors.
PubMed: Self-assembly, reorganization, and photophysical properties of silver(I)-Schiff-base molecular rectangle and polymeric array species.
PubMed: N,N-dimethyl-N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-enylidene]benzene-1,4-diamine and N,N-dimethyl-4-[(1E,3E)-4-(4-nitrophenyl)buta-1,3-dienyl]-1-naphthylamine.
PubMed: Degradation of aniline by newly isolated, extremely aniline-tolerant Delftia sp. AN3.
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