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1,4-diethyleneoxide
Notes:
dehydrating agent; polar solvent miscible both with water & most organic solvents.
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Charkit Chemical Corporation The Specialty Chemical Specialists Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you. about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals. Email: Sales Voice: 203-299-3220 Fax: 203-299-1355 Facebook Twitter Linkedin Latest News Events Blog Products List: View Product(s): DIOXANE, 1,4- (0.003% WATER)
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ECSA Chemicals Human Chemistry ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of the largest distributors worldwide. ECSA Chemicals is the largest Swiss-owned company in terms of warehouses for the distribution of chemical products. We have been distributing chemical products for over 100 years and we have a special interest in protecting the environment and in the safety of our facilities and collaborators. Established in 1913 as a small grocery store, in its over 100 years of activity ECSA Chemicals has become one of the most important Swiss-owned distributors of chemical products. The company, which is active in international distribution and trading, is organised into industrial segments that are managed by teams of specialists and experts. They guarantee professional and customised consultancy and services. With our experience, we can rapidly and safely connect you with the best suppliers on the market, providing you with a complete search, consulting and assistance service. The focus of our approach and operations is you, our customers. We strive every day to find the best products that satisfy your needs as quickly as possible. Your satisfaction is our greatest success. WHY CHOOSE ECSA? EXPERIENCE We have been working for 100 years. QUALITY We have obtained many certifications (ISO, SQAS, GDP, Responsible Care, Bio-Inspecta, RSPO, etc.). We guarantee full compliance with the current laws and continuous training for our staff. SAFETY We constantly carry out risk analyses for each infrastructure, defining safety levels and implementing corrective measures promptly wherever they are needed. WIDESPREAD DISTRIBUTION We have warehouses in strategic locations to supply goods to Switzerland and to the rest of the world. STORAGE CAPACITY The 3 ECSA-owned warehouses guarantee considerable storage area and capacity in each warehouse, with full availability of products (base chemicals and speciality chemicals). SPEED Presence all over the country, staff dedicated to sourcing raw materials and considerable storage capacity guarantee that goods are rapidly obtained and supplied. CONSULTANCY Our specialists - in-depth knowledge of the market and products allows us to provide full consulting services, from the purchase to the supply of raw materials. Email: Info Email: Sales Email: Trading Email: Maintenance Email: Energy Voice: +41 91 695 88 00 Fax: +41 91 695 88 01 Linkedin Youtube RSS Feed ECSA Trade ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY Products List: View Product(s): RE-338003 1,4-DIOXANE RE-PURE, ML 2500 RE-443202 1,4-DIOXANE RPE-ACS-FOR ANALYSIS-REAG. PH.EU
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Glentham Life Sciences Ltd The Chemical, Biochemical & Research Essentials Supplier Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK. With a Glentham Life Sciences account you can view more product details, request quotes and order products online. Email: Info Email: Sales Email: Tech Support Voice: +44 (0) 1225 667798 Fax: +44 (0) 2033 978909 Facebook Twitter Linkedin Google+ News Distribution Products List: View Product(s): GK4038 1,4-Dioxane
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): D0860 1,4-Dioxane >99.0%(GC)
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| CAS Number: | 123-91-1 |  3D/inchi
|
| Other(deleted CASRN): | 28347-88-8 | |
| ECHA EINECS - REACH Pre-Reg: | 204-661-8 | |
| FDA UNII: | J8A3S10O7S | |
| Nikkaji Web: | J2.502J | |
| Beilstein Number: | 0102551 | |
| MDL: | MFCD00006571 | |
| XlogP3: | -0.30 (est) | |
| Molecular Weight: | 88.10616000 | |
| Formula: | C4 H8 O2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FDA Mainterm (IAUFC): | 123-91-1 ; 1,4-DIOXANE |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.03400 @ 25.00 °C. |
| Melting Point: | 11.80 °C. @ 760.00 mm Hg |
| Boiling Point: | 101.50 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 38.233002 mmHg @ 25.00 °C. (est) |
| Flash Point: | 54.00 °F. TCC ( 12.22 °C. ) |
| logP (o/w): | -0.270 |
| Soluble in: | |
| water, 2.139e+005 mg/L @ 25 °C (est) | |
| water, 1.00E+06 mg/L @ 20 °C (exp) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BASF |
| 1,4-Dioxane |
| Charkit Chemical |
| DIOXANE, 1,4- (0.003% WATER) |
| ECSA Chemicals |
| 1,4-DIOXANE RE-PURE, ML 2500 |
| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| ECSA Chemicals |
| 1,4-DIOXANE RPE-ACS-FOR ANALYSIS-REAG. PH.EU |
| EMD Millipore |
| For experimental / research use only. |
| 1,4-Dioxane |
| Glentham Life Sciences |
| 1,4-Dioxane |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 1,4-Dioxane ≥99% |
| Sigma-Aldrich |
| For experimental / research use only. |
| 1,4-Dioxane anhydrous, 99.8% |
| TCI AMERICA |
| For experimental / research use only. |
| 1,4-Dioxane >99.0%(GC) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-cat LD50 2000 mg/kg Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939. intravenous-cat LDLo 1500 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: IRRITABILITY Journal of Hygiene. Vol. 35, Pg. 540, 1935. oral-guinea pig LD50 3150 mg/kg KIDNEY, URETER, AND BLADDER: OTHER CHANGES BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: OTHER CHANGES Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. intraperitoneal-mouse LD50 790 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947. oral-mouse LD50 5300 mg/kg Indian Journal of Experimental Biology. Vol. 16, Pg. 54, 1978. oral-rabbit LD50 2000 mg/kg Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939. intravenous-rabbit LDLo 1500 mg/kg KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED Journal of Hygiene. Vol. 35, Pg. 540, 1935. intraperitoneal-rat LD50 799 mg/kg Environmental Research. Vol. 40, Pg. 411, 1986. oral-rat LD50 4200 mg/kg Industrial Health. Vol. 32, Pg. 145, 1994. | |
| Dermal Toxicity: | |
|
skin-rabbit LD50 7600 uL/kg Union Carbide Data Sheet. Vol. 12/17/1971 | |
| Inhalation Toxicity: | |
|
inhalation-cat LCLo 44000 mg/m3/7H BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA "Beitrag zur Toxikologischen Wirkung Technischer Losungsmittel, Dissertation," Klimmer, O., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1937Vol. -, Pg. -, 1937. inhalation-human LCLo 470 ppm/3D LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LIVER: OTHER CHANGES Pollution Engineering. Vol. 7(9), Pg. 22, 1975. inhalation-human TCLo 470 ppm GASTROINTESTINAL: OTHER CHANGES VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD AMA Archives of Industrial Health. Vol. 20, Pg. 445, 1959. inhalation-human TCLo 5500 ppm/1M SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Public Health Reports. Vol. 45, Pg. 2023, 1930. inhalation-mammal (species unspecified) LC50 20500 mg/m3 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986. inhalation-mouse LC50 37000 mg/m3/2H "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 63, 1982. inhalation-rat LC50 46000 mg/m3/2H SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Kosmicheskaya Biologiya I Aviakosmicheskaya Meditsina. Space Biology and Aerospace Medicine. Vol. 11(6), Pg. 53, 1977. | |
Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis | ||
| Recommendation for 1,4-dioxane usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for 1,4-dioxane flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ECHA (ESR): | View |
| EPA-Iris: | IRIS |
| NIOSH International Chemical Safety Cards: | search |
| NIOSH Pocket Guide: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Carcinogenic Potency Database: | Search |
| EPA GENetic TOXicology: | Search |
| EPA Substance Registry Services (TSCA): | 123-91-1 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 31275 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| 1,4-dioxane | |
| Chemidplus: | 0000123911 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 123-91-1 |
References:
| 1,4-dioxane | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 123-91-1 |
| Pubchem (cid): | 31275 |
| Pubchem (sid): | 134974749 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| UM BBD: | Search |
| KEGG (GenomeNet): | C14440 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2932.99.9090 |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •commercial 1,4-dioxane: purity, 99.90 wt% min; acidity (as acetic acid), 100 ppm max; water, 150 ppm max; peroxide, 5 ppm max; non-volatile matter 0.0025 gm100 ml max; suspended matter, nil •grade: reagent, technical, spectrophotometric, scintillation. | |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| di (ethylene oxide) | |
| di(ethylene oxide) | |
| diethylene dioxide | |
| 1,4- | diethylene dioxide |
| diethylene ether | |
| diethylene oxide | |
| 1,4- | diethylenedioxide |
| 1,4- | diethyleneoxide |
| diokan | |
| dioksan | |
| 1,4- | dioxacyclohexane |
| p- | dioxane |
| dioxane, 1,4- | |
| dioxanne | |
| ethylene glycol ethylene ether | |
| glycol ethylene ether | |
| glycolethylenether |